Institution
Minia University
Education•Minya, Egypt•
About: Minia University is a education organization based out in Minya, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 4967 authors who have published 8986 publications receiving 108384 citations.
Topics: Population, Medicine, Adsorption, Catalysis, Computer science
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that early administration of NSAIDs, including ibuprofen, in CO VID-19 is not only safe but it might also prevent COVID-19 complications and this manuscript explains some of the suggested associated protective mechanisms.
54 citations
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TL;DR: Novel evidence is provided that TCZ has a protective effect against sepsis-induced ALI and AKI by blocking IL-6 receptor signaling, which could provide a molecular basis for a new medical treatment for sepsi-inducedALI andAKI.
Abstract: Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experimental studies have demonstrated the importance of IL-6 in sepsis; however, the role of TCZ has not been investigated. Rats subjected to CLP developed histological evidence of ALI and AKI at 24 h. We found that TCZ alleviated sepsis-induced ALI and AKI as evidenced by improvements in various pathological changes, a significant reduction in the lung wet/dry weight ratio and total protein content in bronchoalveolar lavage fluid (BALF), and a significant decrease in the elevated serum level of creatinine (CR) and blood urea nitrogen (BUN). TCZ induced an increase in the survival rate of treated rats. Additionally, TCZ markedly inhibited sepsis-induced pulmonary and renal inflammatory responses. Moreover, we found that treatment with TCZ inhibited oxidative stress and apoptosis in lung and kidney tissue. TCZ treatment significantly inhibited NF-κB activation, attenuating JNK signaling pathway and significantly up-regulated P-glycoprotein (P-gp) expression in pulmonary as well as in renal tissues. Our data provide novel evidence that TCZ has a protective effect against sepsis-induced ALI and AKI by blocking IL-6 receptor signaling. This could provide a molecular basis for a new medical treatment for sepsis-induced ALI and AKI.
54 citations
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TL;DR: The results suggest that niosomes may be promising vehicles for transdermal delivery of MX and a marked increase in the percentage inhibition of edema in animals treated with MX vesicular gel may be attributed to its superior skin permeation.
Abstract: Context: Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects.Objectives: The aim of this study was to develop transdermal MX in niosomes.Materials and Methods: Vesicles prepared by thin film hydration method were characterized and the acute anti-inflammatory activity of 0.5% MX niosomal hydrogel was evaluated using carrageenan induced rat paw edema method. Results: The results revealed that niosomes prepared from span 60 and cholesterol at 6:4 molar ratio using 20 mg of MX were of the highest entrapment efficiency (> 55%) and with particle size (187.3 nm). There was a marked increase in the percentage inhibition of edema in animals treated with MX vesicular gel compared to those treated with free MX and piroxicam gels.Discussion: There was an inverse proportionality between vesicle size and cholesterol content. With increased cholesterol molar ratio the bilayer stability increased and permeability decreased leading to efficiently tr...
54 citations
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TL;DR: In this paper, the authors focused on the critical analysis of all available drill hole data and seismic reflection records in the Abu Gharadig Basin area, which lies principally to the east of the Qattara Depression in the central portion of the Northern Western Desert of Egypt, and indicated that the basin is an elliptical, multicyclic, E-W trending structurally-controlled basin developed originally as a result of the deep crustal extensional tectonics that affected Northern Egypt during the Mesozoic Era.
54 citations
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TL;DR: Brown hares and African cape hares might be connected via the Near East by gene flow along a network of intergrading populations that have regionally distinct gene pools, and concordant with earlier multilocus allozyme and mtDNA RFLP data, but contrast with mtDNA sequence data published earlier.
54 citations
Authors
Showing all 5017 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hak Yong Kim | 77 | 556 | 24215 |
Peter G. Jones | 69 | 2432 | 34349 |
Ahmed Ali | 61 | 728 | 15197 |
Timothy J. Bartness | 61 | 207 | 12956 |
Munekazu Iinuma | 51 | 436 | 11236 |
Ian T. Jackson | 50 | 312 | 9236 |
Mohamed Elhoseny | 49 | 240 | 7044 |
Nasser A.M. Barakat | 49 | 250 | 8243 |
Mohamed E. Mahmoud | 47 | 415 | 8645 |
Ayman Al-Hendy | 45 | 275 | 5878 |
Jasmin Jakupovic | 43 | 458 | 8944 |
Tom J. Mabry | 42 | 459 | 13375 |
Gábor Tóth | 42 | 506 | 9011 |
Mohammad Ali Abdelkareem | 40 | 182 | 4369 |
Mohamed A. Mohamed | 39 | 274 | 5824 |