Minia University

About: Minia University is a education organization based out in Minya, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 4967 authors who have published 8986 publications receiving 108384 citations.

Neutrophil depletion in the early inflammatory phase delayed cutaneous wound healing in older rats: improvements due to the use of un-denatured camel whey protein

Abstract: While it is known that advanced age alters the recruitment of neutrophils during wound healing, thereby delaying the wound healing process, little is known about prolonged wound healing in advanced ages. Thus, we investigated the correlation of neutrophil recruitment with healing events, and the impact of whey protein (WP) on neutrophil activation. The animals were allocated into wounded young group, wounded older group and wounded older rats with daily treatment of WP at a dose of 100 mg/kg of body weight. Our results pointed to a marked deficiency in the number of neutrophils in the wounds of older rats, which was accompanied with impairment of the healing process. In the group of older rats, phagocytic activity, as tested by fluorescence microscopy, declined throughout the first 24 hours after wounding. Both the neutrophil number and the phagocytic activity recovered in older rats which received WP supplementation. Interestingly, WP was found to significantly up-regulate the MIP-1α and CINC-1 mRNA expression in old rats. On the other hand, the wound size in older rats was significantly higher than that in younger ones. Blood angiogenesis was also significantly delayed in the older group as opposed to the young rats. WP, however, was found to return these indices to normal levels in the older rats. Proliferation and epidermal migration of the keratinocytes and the collagen deposition were also returned to the normal rates. This data confirms the critical role of neutrophil recruitment in the early inflammatory phase of wound healing in older rats. In addition, WP protein was used to improve neutrophil function in older rats, healing events returned to a more normal profile. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2100966986117779 .

Endoscopic type 1 tympanoplasty in pediatric patients using tragal cartilage.

Abstract: RESULTS Healing of the TM healing occurred in 34 patients (85%) in the younger group vs 36 patients (90%) in the older group. Both groups had notable improvement compared with the preoperative measurements, with no significant differences between the 2 groups. Thirty patients (75%) in the younger group had improvement in their ABG vs 32 patients (80%) in the older group, with a mean ABG of 8.0 dB and 10.5 dB in the younger and older groups, respectively. Both groups had significant functional success with no significant differences between the 2 groups. Sixty patients (75%) displayed a type A tympanogram at their 6-month postoperative audiometric testing (28 patients in the younger group vs 32 patients in the older group). There were no statistically significant differences regarding the anatomical and functional success between the patients who had previously undergone adenotonsillectomy and the other patients. The mean (SD) operation duration was 55.03 (2.50) minutes. CONCLUSIONS AND RELEVANCE In pediatric patients undergoing type I tympanoplasty, the endoscopic approach using the tragal cartilage as a grafting material resulted in successful anatomical and functional outcomes that are in comparable to other techniques but with a shorter operation duration. Age of the patient, auditory tube dysfunction, and previous adenotonsillectomy were not prognostic factors for this procedure.

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

Abstract: The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal (DMFDMA) in DMF at 150 °C under controlled microwave heating afforded regioselectively 8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-ones 6 rather than the corresponding dihydropyrazolo[5,1-b]quinazolin-8(5H)-ones 4.

Merged Ontology and SVM-Based Information Extraction and Recommendation System for Social Robots

Abstract: The recent technology of human voice capture and interpretation has spawned the social robot to convey information and to provide recommendations. This technology helps people obtain information about a particular topic after giving an oral query to a humanoid robot. However, most of the search engines are keyword-matching mechanism-based, and the existing full-text query search engines are inadequate at retrieving relevant information from various oral queries. With only predefined words and sentence-based recommendations, a social robot may not suggest the correct items, if items retrieved along with the information are not predefined. In addition, the available conventional ontology-based systems cannot extract precise data from webpages to show the correct results. In this regard, we propose a merged ontology and support vector machine (SVM)-based information extraction and recommendation system. In the proposed system, when a humanoid robot receives an oral query from a disabled user, the oral query changes into a full-text query, the system mines the full-text query to extract the disabled user’s needs, and then converts the query into the correct format for a search engine. The proposed system downloads a collection of information about items (city features, diabetes drugs, and hotel features). The SVM identifies the relevant information on the item and removes anything irrelevant. Merged ontology-based sentiment analysis is then employed to find the polarity of the item for recommendation. The system suggests items with a positive polarity term to the disabled user. The intelligent model and merged ontology were designed by employing Java and Protege Web Ontology Language 2 software, respectively. Experimentation results show that the proposed system is highly productive when analyzing retrieved information, and provides accurate recommendations.