Moorfields Eye Hospital

About: Moorfields Eye Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Visual acuity & Glaucoma. The organization has 3721 authors who have published 6790 publications receiving 246004 citations.

Age-related macular degeneration: diagnosis and management.

Abstract: Background Age-related macular degeneration (AMD) is a leading cause of blind registration in Western Europe and the third leading cause of blindness worldwide. Methods The management of AMD is discussed with a review of current and new treatments. Results Although there is no treatment for advanced dry AMD (geographic atrophy), there have been considerable advances in the management of neovascular AMD (nAMD). Established therapies for nAMD include laser photocoagulation and photodynamic therapy (PDT), but these have largely been superseded by agents which block the action of vascular endothelial growth factor (anti-VEGF agents). Current preventative strategies involve cessation of smoking and use of specific nutritional supplements to reduce the risk of developing nAMD. Conclusions There have been exciting advances in the treatment of nAMD and increased understanding of the genetics and pathogenic mechanisms involved will hopefully lead to the development of new therapies in the future.

Bruch's membrane change with age.

Abstract: Age related macular disease is now the commonest cause of registered blindness in western communities,'4 and it is evident that the prevalence is rising with the increasing age of the population.5 6 Both the realisation of the high prevalence of disease, and the prospects of therapy,7-9 have stimulated recent interest in the disorder. Unfortunately it has now become evident that laser treatment will not have a major impact on blindness from age related macular disease. \"'I Since the historic monograph of Gass'3 there has been increasing clinical and laboratory research which has highlighted the role of neovascularisation and retinal pigment epithelial dysfunction in the pathogenesis of the disorder. However, there is still incomplete information on the natural history and the basic pathogenesis of age related macular disease, and the factors which determine the risk of visual loss are ill understood. There is now increasing circumstantial evidence that the chemical composition of deposits in Bruch's membrane may be an important determinant of the outcome of disease. It is hoped that current pathogenetic concepts will form a rational basis for future studies.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease

Abstract: The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. We have divided this review into two parts. Part I summarizes the epidemiology and immunopathogenesis of SJS/TEN and discusses systemic therapy and its possible benefits. We hope this review will help the ophthalmologist better understand the mechanisms of disease in SJS/TEN and enhance their care of patients with this complex and often debilitating disease. Part II (April 2016 issue) will focus on ophthalmic manifestations.