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Angela J. Cree
Researcher at University of Southampton
Publications - 54
Citations - 3500
Angela J. Cree is an academic researcher from University of Southampton. The author has contributed to research in topics: Macular degeneration & Population. The author has an hindex of 21, co-authored 51 publications receiving 2747 citations. Previous affiliations of Angela J. Cree include Southampton General Hospital.
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Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
Gudmar Thorleifsson,G. Bragi Walters,Alex W. Hewitt,Alex W. Hewitt,Gisli Masson,Agnar Helgason,Agnar Helgason,Andrew T. DeWan,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Sigurjon A. Gudjonsson,Kristinn P. Magnusson,Hreinn Stefansson,Dennis S.C. Lam,Pancy O. S. Tam,Gudrun J Gudmundsdottir,Laura Southgate,Kathryn P. Burdon,Maria Soffia Gottfredsdottir,Micheala A. Aldred,Paul Mitchell,David St Clair,David A. Collier,David A. Collier,Nelson L.S. Tang,Orn Sveinsson,Stuart MacGregor,Nicholas G. Martin,Angela J. Cree,Jane Gibson,Alex MacLeod,Aby Jacob,Sarah Ennis,Terri L. Young,Juliana C.N. Chan,W Karwatowski,Christopher J Hammond,Kristjan Thordarson,Mingzhi Zhang,Claes Wadelius,Andrew J. Lotery,Richard C. Trembath,Chi Pui Pang,Josephine Hoh,Jamie E Craig,Augustine Kong,David A. Mackey,David A. Mackey,David A. Mackey,Fridbert Jonasson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +53 more
TL;DR: The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.
Journal ArticleDOI
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
Yi Lu,Veronique Vitart,Kathryn P. Burdon,Chiea Chuen Khor,Yelena Bykhovskaya,Alireza Mirshahi,Alex W. Hewitt,Alex W. Hewitt,Demelza Koehn,Pirro G. Hysi,Wishal D. Ramdas,Tanja Zeller,Eranga N. Vithana,Belinda K. Cornes,Wan Ting Tay,E. Shyong Tai,Ching-Yu Cheng,Jianjun Liu,Jianjun Liu,Jia Nee Foo,Seang-Mei Saw,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson,David P. Dimasi,Richard A. Mills,Jenny Mountain,Wei Ang,René Hoehn,Virginie J. M. Verhoeven,Franz H. Grus,Roger C. W. Wolfs,Raphaële Castagné,Karl J. Lackner,Henriët Springelkamp,Jian Yang,Fridbert Jonasson,Dexter Y L Leung,Li J. Chen,Clement C Y Tham,Igor Rudan,Igor Rudan,Zoran Vatavuk,Caroline Hayward,Jane Gibson,Angela J. Cree,Alex MacLeod,Sarah Ennis,Ozren Polasek,Harry Campbell,James F. Wilson,Ananth C. Viswanathan,Brian W Fleck,Xiaohui Li,David S. Siscovick,Kent D. Taylor,Jerome I. Rotter,Seyhan Yazar,Megan Ulmer,Jun Li,Brian L. Yaspan,Ayse Bilge Ozel,Julia E. Richards,Sayoko E. Moroi,Jonathan L. Haines,Jae H. Kang,Louis R. Pasquale,Louis R. Pasquale,R. Rand Allingham,Allison E. Ashley-Koch,Paul Mitchell,Jie Jin Wang,Alan F. Wright,Craig E. Pennell,Tim D. Spector,Terri L. Young,Terri L. Young,Caroline C W Klaver,Nicholas G. Martin,Grant W. Montgomery,Michael G. Anderson,Tin Aung,Colin E. Willoughby,Janey L. Wiggs,Chi P. Pang,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andrew J. Lotery,Christopher J Hammond,Cornelia M. van Duijn,Michael A. Hauser,Yaron S. Rabinowitz,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Jamie E Craig,Stuart MacGregor,Tien Yin Wong,Tien Yin Wong +98 more
TL;DR: A meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance showed that 2 CCT-associated loci conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls.
Journal ArticleDOI
Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study
Sarah Ennis,Catherine Jomary,Robert F. Mullins,Angela J. Cree,Xiaoli Chen,Alex MacLeod,Stephen E. Jones,Andrew Collins,Edwin M. Stone,Edwin M. Stone,Andrew J. Lotery +10 more
TL;DR: A secondary high-density genotyping study across the SERPING1 gene region identified five additional SNP variants similarly associated with age-related macular degeneration that might implicate the classic pathway of complement activation in this disease.
Journal ArticleDOI
Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression
Jamie E Craig,Xikun Han,Xikun Han,Ayub Qassim,Mark M. Hassall,Jessica N. Cooke Bailey,Tyler G. Kinzy,Anthony P Khawaja,Jiyuan An,Henry Marshall,Puya Gharahkhani,Robert P. Igo,Stuart L. Graham,Paul R. Healey,Jue-Sheng Ong,Tiger Zhou,Owen M. Siggs,Matthew Law,Emmanuelle Souzeau,Bronwyn Ridge,Pirro G. Hysi,Kathryn P. Burdon,Richard A. Mills,John Landers,Jonathan B Ruddle,Ashish Agar,Anna Galanopoulos,Andrew White,Colin E. Willoughby,Nicholas H Andrew,Stephen Best,Andrea L Vincent,Ivan Goldberg,Graham L. Radford-Smith,Nicholas G. Martin,Grant W. Montgomery,Veronique Vitart,René Hoehn,René Hoehn,Robert Wojciechowski,Robert Wojciechowski,Jost B. Jonas,Tin Aung,Louis R. Pasquale,Angela J. Cree,Sobha Sivaprasad,Neeru A. Vallabh,Neeru A. Vallabh,Ananth C. Viswanathan,Francesca Pasutto,Jonathan L. Haines,Caroline C W Klaver,Cornelia M. van Duijn,Robert J Casson,Paul J. Foster,Peng T. Khaw,Christopher J Hammond,David A. Mackey,David A. Mackey,Paul Mitchell,Andrew J. Lotery,Janey L. Wiggs,Alex W. Hewitt,Stuart MacGregor +63 more
TL;DR: This glaucoma PRS will facilitate the development of a personalized approach for earlier treatment of high-risk individuals, with less intensive monitoring and treatment being possible for lower-risk groups.