Institution
Mulago Hospital
Healthcare•Kampala, Uganda•
About: Mulago Hospital is a healthcare organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 542 authors who have published 545 publications receiving 34804 citations.
Papers published on a yearly basis
Papers
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TL;DR: House design improved rapidly in rural Uganda and was associated with additional reductions in mosquito density and parasite prevalence following the introduction of indoor residual spraying, and changes to house design in endemic Africa might help further the gains achieved with more widely accepted malaria control interventions.
44 citations
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TL;DR: Changes in serum-aminoacid patterns have been studied in children fed different levels of protein after recovery from kwashiorkor and can be a useful component of the profile revealing the nature of a child's adaptation to nutritional stress.
44 citations
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TL;DR: The findings challenge conventional recommendations against collecting salivary sputum for TB diagnosis and could inform new standards forSputum quality and demonstrate the need to exercise caution in collecting sputsum for Xpert and in interpreting results because sputu quality may impact test yield and sensitivity.
Abstract: Author(s): Meyer, Amanda J; Atuheire, Collins; Worodria, William; Kizito, Samuel; Katamba, Achilles; Sanyu, Ingvar; Andama, Alfred; Ayakaka, Irene; Cattamanchi, Adithya; Bwanga, Freddie; Huang, Laurence; Davis, J Lucian | Abstract: BackgroundIntroduction of GeneXpert MTB/RIF (Xpert) assay has constituted a major breakthrough for tuberculosis (TB) diagnostics. Several patient factors may influence diagnostic performance of Xpert including sputum quality.ObjectiveWe carried out a prospective, observational, cross-sectional study to determine the effect of sputum quality on diagnostic performance of Xpert among presumed TB patients in Uganda.MethodsWe collected clinical and demographic information and two sputum samples from participants. Staff recorded sputum quality and performed LED fluorescence microscopy and mycobacterial culture on each sample. If both smear examinations were negative, Xpert testing was performed. We calculated diagnostic yield, sensitivity, specificity, and other indicators for Xpert for each stratum of sputum quality in reference to a standard of mycobacterial culture.ResultsPatients with salivary sputum showed a trend towards a substantially higher proportion of samples that were Xpert-positive (54/286, 19%, 95% CI 15-24) compared with those with all other sputum sample types (221/1496, 15%, 95% CI 13-17). Blood-stained sputum produced the lowest sensitivity (28%; 95% CI 12-49) and salivary sputum the highest (66%; 95% CI 53-77). Specificity didn't vary meaningfully by sample types. Salivary sputum was significantly more sensitive than mucoid sputum (+13%, 95% CI +1 to +26), while blood-stained sputum was significantly less sensitive (-24%, 95% CI -42 to -5).ConclusionsOur findings demonstrate the need to exercise caution in collecting sputum for Xpert and in interpreting results because sputum quality may impact test yield and sensitivity. In particular, it may be wise to pursue additional testing should blood-stained sputum test negative while salivary sputum should be readily accepted for Xpert testing given its higher sensitivity and potentially higher yield than other sample types. These findings challenge conventional recommendations against collecting salivary sputum for TB diagnosis and could inform new standards for sputum quality.
42 citations
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Oregon Health & Science University1, Yale University2, Ahmadu Bello University3, Nairobi Hospital4, University of Toronto5, University of Malawi6, University of California, Los Angeles7, Tanta University8, Albany Medical College9, University of Ghana10, University of Oxford11, Maine Medical Center12, Nationwide Children's Hospital13, Texas Tech University Health Sciences Center at El Paso14, Norwich University15, University of Ilorin16, Women & Children's Hospital of Buffalo17, Mulago Hospital18
TL;DR: This work states that Africa, in particular, has a grave shortage of paediatric surgeons and there are critical shortages in workforce and skills to treat these diseases in LMICs.
Abstract: Attention to surgical conditions in lowand middle-income countries (LMICs) has increased in recent years. Because half of the population in the world’s poorest countries are children [1], paediatric surgical conditions compose a significant proportion of the global burden of disease (BoD), and there are critical shortages in workforce and skills to treat these diseases in LMICs. Several populationbased studies have highlighted the magnitude of the need for paediatric surgery and the limited capacity, both in human resources and in infrastructure, to tackle the problem [2, 3]. Africa, in particular, has a grave shortage of paediatric surgeons. The number of fully trained paediatric surgeons ranges from 1 in Malawi (population 13 million) to 120 in Egypt (population of 80 million). In more than
41 citations
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TL;DR: The PrePex device was well accepted, but healing was slower than with dorsal slit surgery, and the need to return for removal and delayed healing may increase Program cost and client burden.
Abstract: Objectives
To assess the safety and acceptance of the PrePex device for medical male circumcision (MMC) in rural Uganda.
41 citations
Authors
Showing all 545 results
Name | H-index | Papers | Citations |
---|---|---|---|
Moses R. Kamya | 60 | 435 | 12598 |
Jordan J. Feld | 57 | 277 | 13444 |
Eloi Marijon | 47 | 352 | 10005 |
Sarah G. Staedke | 47 | 169 | 6095 |
Harriet Mayanja-Kizza | 43 | 221 | 6804 |
Alphonse Okwera | 42 | 88 | 5187 |
Joo-Hyun Nam | 41 | 231 | 7216 |
James K Tumwine | 41 | 214 | 5413 |
Ian Crozier | 40 | 142 | 7922 |
Cissy Kityo | 39 | 196 | 5926 |
Philippa Musoke | 37 | 138 | 7778 |
Andrew Kambugu | 36 | 184 | 5195 |
Denis Burkitt | 35 | 73 | 8491 |
Richard Idro | 35 | 139 | 4312 |
Robert O. Opoka | 33 | 170 | 4927 |