North Bengal Medical College

About: North Bengal Medical College is a other organization based out in Darjeeling, India. It is known for research contribution in the topics: Population & Cancer. The organization has 624 authors who have published 691 publications receiving 5492 citations.

Unusual case of coin in larynx (glottic chink) presenting as Dysphagia.

Abstract: Foreign body larynx is a rare condition in adults — inhalation of coin and impaction of the coin in the glottic chink is more rare finding. But this patient presented with difficulty in swallowing and speech, without any respiratory trouble — Hence the case is reported.

Relation between metabolic syndrome and psoriasis: A multicenter, hospital-based, case-control study from West Bengal, India

Abstract: Introduction: Psoriasis is a chronic, inflammatory, immune-mediated skin disease affecting approximately 2-3% of the global population. Besides traditional co-morbidities associated with psoriasis, an emerging co-morbidity is metabolic syndrome. Psoriasis and metabolic syndrome are likely linked together due to underlying chronic inflammatory nature of psoriasis, in large part, to the increased tumor necrosis factor-alpha. Aim: To study the association between psoriasis and metabolic syndrome and its components. Materials and Methods: A case-control, hospital-based multicenter study was designed including 173 consecutive psoriatic patients and 184 nonpsoriatic subjects as control during a period of 2 years. In this study, we statistically compared the components of metabolic syndrome (using National Cholesterol Education Program Adult Treatment Panel criteria) in case and control groups. Results: Out of 173 psoriatic patients, there were 91 men (52.6%) and 82 women (44.56%); and in the control group, there were 93 men (50.54%) and 91 women (49.45%). We found a higher proportion of psoriatic patients having features of metabolic syndrome compared to the control group (40.46% vs. 22.28%), the difference was statistically significant (p < 0.0001). Prevalence of obesity in terms of waist circumference (p = 0.001) and body mass index (p = 0.001), and dyslipidemia (p = 0.004) were significantly associated with psoriasis, whereas prevalence of hypertension (p = 0.11) and diabetes (p = 0.93) were not associated with psoriasis. Conclusion: Psoriasis is statistically positively associated with metabolic syndrome in our study.

Acute retention of urine due to prostatic a abscess.

Abstract: There is evidence that alcohol may increase iron absorption I. It has been known that heavy iron deposits are frequently found in the tissues of the Bantu population and similar incidences have been described in Zambia and Ghana", The plasma iron and TIBC are often very high in the patient with haemochromatosis, but sometimes may be normal or even low! as in our patient. The only reliable confirmation of haemochromatosis is by liver biopsy (Figures 1 and 2). We suggest that though this is a very rare disease (prevalence

Study of Electrolyte status in patients with Thyroid dysfunction attending a tertiary care hospital of North Bengal.

Abstract: Context : Thyroid disorders have widespread systemic manifestations including their effects on body mineral homeostasis in many different ways. Thyroid hormones control urinary excretion of minerals like Magnesium, zinc, sodium, potassium etc and minerals like Zn helps in peripheral conversion of inactive T4 to its active T3 form. Electrolyte abnormality is a common finding in the patients with thyroid dysfunction which can effect the disease morbidity. Aims & Objective : The present study was carried out to access the importance of Electrolyte status in the study subjects and to use the information for lowering the mortality and morbidity associated with the disease process. Materials &Methods : The study population was divided into normal control group consisting of 40 healthy individuals and a test group consisting of 80 patients out of whom 40 were diagnosed to be having primary hypothyroidism and 40 to be having primary hyperthyroidism. Electrolyte status was assessed by serum calcium, serum phosphorus, serum magnesium, serum zinc, serum sodium and serum potassium Results : There is a significant increase in levels of serum calcium and phosphorus in group-II (P<0.001) and significant decrease in their levels in group-I (P<0.001) compared to control. Serum Magnesium showed a significant decrease in test groups-II (P<0.001) and increase in test group-I (P<0.001) compared to controls. Serum sodium showed significant decrease in test group-I (P<0.001) and test group-II (P=0.007) but the study did not show any significant difference in level of serum zinc and potassium in test group-I and II when compared to controls. Conclusion : Thyroid dysfunction results in an array of electrolyte abnormalities which increases the morbidity and mortality of the disease process. By proper maintenance of the electrolytes within normal limit, we can employ preventive strategies for better management of the patients and thereby improve their survival.

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

Abstract: Extended-spectrum β-lactamase (ESBL) producing bacteria acts as a serious threat, and its co-existence with other antibiotic resistant gene makes the clinical scenario worse nowadays. Therefore in this study, we investigated the occurrence of ESBL genes coexisting with carbapenem, AmpC and aminoglycoside resistance gene in uropathogens. Out of 1516 urine samples, 454 showed significant bacteriuria with a prevalence rate of 29.94 %. Escherichia coli (n=340) were found to be the most predominant uropathogen followed by Klebsiella pneumoniae (n=92), Pseudomonas aeruginosa (n=10) and Proteus mirabilis (n=9). Among the total uropathogens, sixty-three ESBL-producers were identified which included blaCTX-M-15 (n=32), followed by blaCTX-M-15 + blaOXA-2 (n=15), blaCTX-M-15 + blaOXA-2 + blaTEM(n=6), blaOXA-2 (n=5), bla OXA-2 + blaSHV-76 (n=1), bla TEM+SHV-76 (n= 1) and blaTEM (n=1). All ESBL genes were found on plasmid incompatibility types: HI1, I1, FIA+FIB, FIA and Y and were horizontally transferable. Among 63 ESBL-producers, 59 isolates harboured carbapenem-resistant genes which included blaNDM-5 (n=48), blaNDM-5 + blaOXA-48 (n=5), blaNDM-5 + blaIMP (n=5) and blaNDM-5 + blaIMP + blaVIM (n=1). The ESBL producing uropathogens also harbored 16S rRNA methylase genes which included rmtB (n=9), rmtA (n=4), rmtC (n=1) and ArmA (n=1) followed by AmpC genes which includes CIT (n=8) and DHA-1 (n=1) genes. Imipenem and gentamicin were found to be more effective. We speculating, this is the first report showing the prevalence of multidrug-resistant uropathogens in this area demanding regular surveillance for such resistance mechanisms which will be useful for health personnel to treat ESBL infection and its co-existence with another antibiotic resistance gene.