North Bengal Medical College

About: North Bengal Medical College is a other organization based out in Darjeeling, India. It is known for research contribution in the topics: Population & Cancer. The organization has 624 authors who have published 691 publications receiving 5492 citations.

UNUSUAL BREAST DISEASE MIMICKING MALIGNANCY; LYMPHOCYTIC MASTITIS. A CASE REPORT. Meme kanserini taklit eden sıradışı bir hastalık; Lenfositik mastit. Olgu sunumu.

Abstract: Lymphocytic mastitis is an uncommon presentation of benign breast disease. It may present as a painful or painless lump in the breast. Clinical examination and imaging often raises suspicion of malignancy. Thus biopsy and histopathological examination is generally required. It is usually associated with diabetes mellitus or some other autoimmune disorder. However, we present an unusual presentation of lymphocytic mastitis without any association. OZET Lenfositik mastitler nadir gorulen benign meme hastaliklarindandir. Memede agrili veya agrisiz kitle seklinde kendini gosterebilir. Klinik muayene ve goruntuleme tetkikleri ile malignite suphesi ile siklikla biyopsi yapilirlar. Hastalar siklikla diyabet ve otoimmun bozukluklarla birliktelik gosterir. Burada izole bir lenfosittik mastit olgusu sunulmustur.

A study of CBS gene polymorphism, plasma H2S levels and their association in type-2 diabetes mellitus

Abstract: Background: Hydrogen Sulphide (H2S), in recent years, is getting significant attention, as more evidences are emerging about its diverse biological roles. There are evidences of H2S having anti-inflammatory, neuro-modulator, vasodilator, anti-apoptotic and mitochondrial protective roles in various tissues. Among different tissues, β-cells of pancreas, according to some recent studies, get significantly affected by the imbalance in H2S homeostasis, leading to β-cell dysfunction and Diabetes Mellitus (DM). Cystathionine- β-synthase (CBS) enzyme is involved in the synthesis of H2S from cysteine in various tissues. Among various possible mutations in the CBS gene, a particular 833T-C mutation, has been found to be associated with various diseases. Aims and Objectives: The present study was aimed to determine the extent of abnormality of H2S homeostasis in type-2 DM patients, and to find out presence and association (if any) of 833T-C mutation in CBS gene, in the patients of type-2 DM, in comparison to healthy control subjects, in the Indian population. Materials and Methods: A cross sectional study was done with 40 clinically and biochemically diagnosed DM type II patients attending OPD of Endocrinology department of NRS Medical College & Hospital, Kolkata, and 40 age and gender matched non-diabetic control subjects. DNA was isolated from EDTA blood of all the study subjects, PCR done and results compared. Plasma H2S was measured by the N,N-dimethyl-p-phenylene-diamine method. Plasma glucose and serum insulin were measured by standardized commercial kits. Results: Our study found the plasma H2S levels in the patients of type II DM to be significantly higher(P<0.001) than the control subjects. The results also found significant positive correlation between plasma H2S level with fasting serum Insulin level (P<0.001) and fasting plasma glucose level (P<0.001) in the diabetic patients. Among 40 DM patients, only two were heterozygous for the mutation, and had both mutated allele (242bp) and normal allele (174bp). Rest of the patients and all the control subjects were homozygous for the normal allele (174bp). This marginal difference in the incidence of mutated allele was not found to be statistically significant. Conclusion: our study shows significant association of H2S dys-regulation with the type-2 Diabetes Mellitus in Indian population. The marginal but insignificantly higher incidence of 833T-C mutation in CBS gene, found in our study, warrants further research with higher number of study population, to more conclusively infer about the role of this mutation in the pathogenesis of type-2 DM.

Giant Cell Glioblastoma -A Rare Pediatric Cerebral Neoplasm

Abstract: Giant cell glioblastoma is an extremely rare variant of Glioblastoma (WHO grade IV) which is characterized by a predominance of bizarre, multinucleated giant cells. These tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. In pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. Here, we report a case of a 12-year old female patient who presented in outpatient clinic with a short period history of headache and seizures. A CT scan showed a large right sided frontal space occupying lesion with areas of calcification. The patient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased cellularity, atypical mitosis, bizarre multinucleated giant cells along with large areas of ischemic necrosis and calcification. A diagnosis of Giant cell glioblastoma (WHO Grade IV) was made. The patient was symptomatically well at 3-month follow-up.