North Bengal Medical College

About: North Bengal Medical College is a other organization based out in Darjeeling, India. It is known for research contribution in the topics: Population & Cancer. The organization has 624 authors who have published 691 publications receiving 5492 citations.

Argyrophilic nucleolar organizer regions (AgNOR) in tumours of pharynx and larynx

Abstract: Benign and Malignant squamous cell tumours from pharynx and larynx have been studied by silver colloidal staining technique for quantitative analysis of argyrophilic nucleolar organizer regions (AgNOR) per nucleus and to assess its significance in differentiating the benign from malignant tumours. A total of 23 neoplasms including 8 squamous papillomas from larynx, 5 squamous cell cracinomas from larynx and 10 squamous carcinomas from pharynx have been studied. AgNOR count from benign papillomas showed a mean count of 2.56 whereas that in squamous cell carcinoma of Pharynx and larynx was 12.61 and 11.43 respectively. This simple staining method can be used to differentiate benign from malignant tumours in pharynx and larynx.

Glycemic Status During Acute Coronary Syndrome of Non-Diabetic Patients

Abstract: The risk of diabetes mellitus and coronary heart disease is high among South-Asian population. In this study, our objective was to measure blood glucose level during acute coronary syndrome of previously known nondiabetic patients that will give the information about the frequency of acute hyperglycemia in acute coronary syndrome (ACS) among Bangladeshi population. It is an observational cross sectional study performed in Rajshahi Medical College Hospital (RMCH). A total of 248 non-diabetic subjects with ACS got admitted into hospital. Fasting blood glucose (FBS) and standard oral glucose tolerance test (OGTT ) within 3 days of ACS were done. This study was done to find out glucose abnormalities among ACS patients. Out of 248 study population, 135 (54.44%) had glucose abnormalities. Male was 87.10% (216). Among male, IGT (prediabetic) was 31.94% (69) and diabetic 24.54% (53). Mean age (±SD) of our study population was 51.71±11.84 years. Normal glucose tolerance (NGT) was found in 45.6% (113) cases, IGT (prediabetic) and diabetic were detected among 30.6% (76) and 23.8% (59) cases respectively. Non-diabetic Bangladeshi patients showed a high prevalence of hyperglycemia in acute coronary syndrome (ACS). We should create awareness about a new risk factor- acute hyperglycemia during acute coronary syndrome and take appropriate and effective measures to reduce morbidity as well as mortality as a consequence of acute hyperglycemia during ACS with or without diabetes. KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 697-699

Abnormality in serum calcium, phosphate and vitamin-d levels inchronic renal failure patients: a case control study in theeastern indian population

Abstract: Chronic renal failure (CRF) is one of the most important health problems in our population. From the early stages of the disease progression, the activation of Vitamin D in kidney is affected, resulting in abnormality in the regulation of calcium and phosphate homeostasis in the blood. In the present study, 30 Chronic Renal Failure patients visiting Nephrology OPD and 30 age and sex matched volunteers were studied. Serum levels of Urea, Creatinine, Calcium, Phosphate and Vitamin D were measured in the study participants. The data after statistical analysis showed signicantly higher levels of Phophate and signicantly lower levels of Calcium and Vitamin D in the CRF patients in comparison to healthy control subjects. Phosphate and Vitamin D also shows signicant correlation with serum creatinine levels in the CRF patients. The present study conrms the abnormality in Calcium-Phosphorus metabolism as a complication of CRF in our population, and highlights the importance of regularly measuring these parameters in CRF patients and possible need of taking corrective measures in this regard.

Effect of intravenous dexmedetomidine and small dose fentanyl on shoulder tip pain in gynecological laparoscopic surgeries under spinal anaesthesia

Abstract: Background: Shoulder tip pain and discomfort due to peritoneal stretching is the major limiting factor of spinal anaesthesia in laparoscopic surgeries. Aim of the study was to evaluate the effect of intravenous dexmedetomidine along with small dose fentanyl in abolishing the shoulder tip pain during gynaecological laparoscopic surgery and to assess its respiratory and hemodynamic effects. Methods: 50 ASA grade I and II, with age 18-50 yrs and weight 45-70 kgs, who were undergoing elective gynecological laparoscopic surgeries with estimated pneumoperitoneum time of one hour or less, were included in the study. Injection dexmedetomidine 1 mcg/kg was infused over a period of ten minutes before spinal anaesthesia with 3.5 ml of injection ropivacaine (0.75%) in lateral position. Injection fentanyl 0.5mcg/kg was given intravenously before intraperitoneal insufflation. Shoulder tip pain, peri-operative heart rate, noninvasive blood pressure, end tidal carbon dioxide, respiratory rate and sedation level using Ramsay sedation score were assessed at frequent intervals. Results: 35 patients were comfortable with no complaints, 11 patients had mild and two patients had moderate shoulder tip pain which was relieved by reducing abdominal pressure or/and an additional dose of fentanyl (25 mcg). One patient had severe pain and had to be converted to general anaesthesia. Ready sedation score was 2 or 3 for all the patients except one who was deeply sedated and had to be intubated. The drug combination used reduced the shoulder tip pain in gynaecological laparoscopic surgeries performed under spinal anaesthesia while maintaining the stable intra-operative hemodynamics. Conclusions: This study has provided the preliminary evidence of feasibility of use of dexmedetomidine along with low dose fentanyl to reduce the discomfort and shoulder tip pain during gyanaecological laparoscopic procedures of short duration under spinal anaesthesia in selected patients.

Antioxidant potential of gundruk - an ethnic food of sikkim

Abstract: Aim: Gundruk is one of the ethnic foods of Sikkim. Ethnic group in Sikkim believe that gundruk is a good appetizer and keeps their body fit and promotes health. In view of this belief it was thought worthwhile to evaluate antioxidant potential of gundruk. Material & Methods: In vitro antioxidant activity of gundruk was measured by superoxide anion generation with the help of xanthine-xanthine oxidase assay, linoleic acid peroxidation assay and by DPPH photometric assay as well as by ABTS radical scavenging assay, hydroxy radical scavenging assay and nitric oxide radical scavenging assay. At the same time total antioxidant capacity of gundruk was determined by phosphomolybdenum method and by ferric reducing power (FRP) method. Anti oxidant compounds like polyphenol, ascorbic acid, flavonoids and carotenoid were also estimated in gundruk. Results: Results showed that gundruk has strong antioxidant activity which was due to its high content of polyphenol. Conclusion: The belief that gundruk keeps body fit and promotes health may have relation with antioxidant activity of gundruk. Keywords: Gundruk, Anti oxidant activity; Polyphenol; Flavonoid; Ascorbic acid; Carotenoids