Northern Illinois University

About: Northern Illinois University is a education organization based out in DeKalb, Illinois, United States. It is known for research contribution in the topics: Large Hadron Collider & Population. The organization has 8818 authors who have published 20008 publications receiving 632341 citations. The organization is also known as: NIU.

That's Interesting!: Towards a Phenomenology of Sociology and a Sociology of Phenomenology

Abstract: Answer: Interesting theories deny certain assumptions of their audience, while noninteresting theories affirm certain assumptions of their audience. This answer was arrived at through the examination of a number of famous social, and especially sociological, theories. That examination also generated a systematic index of the variety of propositional forms that interesting and non-interesting theories may take. The fertility of this approach suggested a new field be established called the Sociology of the Interesting, which is intended to supplement the Sociology of Knowledge. This new field will be phenomenologically oriented in so far as it will focus on the movement of the audience's mind from one accepted theory to another. It will be sociologically oriented in so far as it will focus on the dissimilar base-line theories of the various sociological categories that compose the audience. In addition to its value in interpreting the social impact of theories, the Sociology of the Interesting can contribute to our understanding of both the common sense and scientific perspectives on reality.

Ferroelectricity in ultrathin perovskite films.

Abstract: Understanding the suppression of ferroelectricity in perovskite thin films is a fundamental issue that has remained unresolved for decades. We report a synchrotron x-ray study of lead titanate as a function of temperature and film thickness for films as thin as a single unit cell. At room temperature, the ferroelectric phase is stable for thicknesses down to 3 unit cells (1.2 nanometers). Our results imply that no thickness limit is imposed on practical devices by an intrinsic ferroelectric size effect.

New Microporous Metal−Organic Framework Demonstrating Unique Selectivity for Detection of High Explosives and Aromatic Compounds

Abstract: A highly luminescent three-dimensional microporous metal−organic framework, [Zn2(oba)2(bpy)]·DMA, demonstrates unique selectivity for the detection of high explosives and other aromatics via a fluorescence quenching and enhancement mechanism.

Translocation of inhaled ultrafine manganese oxide particles to the central nervous system.

Abstract: An important step in assessing the toxicology of particles is to determine their fate after inhalation. Of particular interest to us are airborne ultrafine particles (UFPs; < 100 nm), which are abundant in ambient urban air and are of the same size as engineered nanoparticles. Translocation to extrapulmonary sites after respiratory tract deposition represents an important mechanism for these particles to cause direct effects in secondary target organs (Oberdorster et al. 2005). The extent to which this process occurs depends on several factors including particle solubility, particle or aggregate size, the site of deposition, and the integrity of the epithelial lining. UFPs deposit efficiently in all regions of the respiratory tract, depending on their size; specifically, as particle size decreases toward the smallest UFPs, nasopharyngeal deposition increases (International Committee on Radiological Protection 1994). Studies in rats have shown translocation of soluble manganese compounds from the nose along olfactory neuronal pathways to the olfactory bulb (Dorman et al. 2004; Henriksson and Tjalve 2000; Tjalve et al. 1996; Tjalve and Henriksson 1999) after inhalation or intranasal instillation exposures. Likewise, the few studies that have examined the fate of UFPs deposited on the nasal mucosa identified translocation along the neuronal olfactory route as a pathway to the olfactory bulb of the central nervous system (CNS). These include early studies in non-human primates, which demonstrated the translocation of solid nanosized particles (30 nm poliovirus; 50 nm silver-coated gold colloids) along the axons of olfactory nerves into the olfactory bulb (Bodian and Howe 1941a, 1941b; DeLorenzo 1970). We have also shown that inhaled elemental carbon particles (13C; 35 nm, count median diameter) accumulate in rat olfactory bulb after whole-body inhalation (Oberdorster et al. 2004). Regarding penetration into deeper brain regions, Tjalve et al. (1995) demonstrated that soluble ionic Mn instilled into the olfactory chamber of pike has the ability to pass synaptic junctions and migrate from the olfactory tract to more distal regions, including the hypothalamus. Dorman et al. (2004) found Mn in the striatum and cerebellum of rats after subchronic inhalation exposure to a soluble Mn salt (sulfate); however, this was attributed to uptake from the blood. Thus, contributions to brain Mn levels from the blood need to be considered and may also be an issue for inhaled solid UFPs. The effects of translocated particles in the brain are also important to determine. For example, preliminary information has emerged from populations of welders that some of them may develop parkinsonism 17 years earlier than the general population (Racette et al. 2001). Welding produces high amounts of fumes containing Mn UFPs (Zimmer et al. 2002). Several recent epidemiologic studies describe occupational exposure ranges of approximately 0.01–5 mg/m3 Mn in fumes from various welding processes and materials (Korczynski 2000; Li et al. 2004; Sinczuk-Walczak et al. 2001). Conflicting data emerge from animal studies, however, regarding effects of inhaled Mn compounds in the brain. Henriksson and Tjalve (2000) reported changes in glial fibrillary acidic protein (GFAP) and S-100b, markers of astrocyte activation, in several brain regions from rats exposed intranasally to Mn chloride. However, Dorman et al. (2004) did not find any evidence of changes in GFAP levels in the brain after exposure to Mn sulfate or phosphate. Potential contributing factors to the lack of concurrence in results include differences in the solubilities of the Mn salts used, the doses, and the contribution of olfactory epithelial damage. In the present study, we sought to address the hypothesis that a major translocation route for inhaled poorly soluble Mn oxide UFPs from deposits in the nose is to the olfactory bulb in the CNS. We characterized the size, oxidation state, and in vitro solubility of gas-phase–generated Mn oxide particles and also compared the translocation kinetics to the olfactory bulb of Mn oxide and MnCl2 that were applied to the nasal epithelium of rats via instillation. We then measured the accumulation of Mn in lung, liver, and olfactory bulb after repeated inhalation exposures with both nares patent or with one naris occluded. We show that Mn oxide UFPs are translocated to and retained in the olfactory bulb (ipsilateral to the patent naris only) and present evidence of exposure-induced effects in that region of the brain. These studies demonstrate the importance of UFPs size and of solubility in olfactory translocation processes.

Nonparametric indexes for sensitivity and bias: computing formulas.

Abstract: Computing formulas are derived for two nonparametric indexes of sensitivity and bias that have been suggested for signal detectability studies. A relationship is shown between the sensitivity index and P(I), a statistic whose sampling variability is known. An additional index of bias is proposed, which is free of certain inconveniences, yet yields identical isobias contours. Use of the new indexes is illustrated with several sets of data. Development of the theory of signal detectability has lead to a renewed interest in the possible processes involved in perception, psychophysics, and recognition memory. To a considerable extent both theory and research in these areas have rested on specific assumptions about the underlying distributions (as in the various threshold theories versus normality). But even without explicit assumption about the distributions, data are often judged by how close they lie to operating characteristic curves derived from normal distributions, and different experimental conditions are characterized by their value of d'. Recently there has been a growing interest in various "nonparametric" analyses of detection/ recognition experiments, where specific underlying distributions are not assumed. Following one line of development, Green (1964) has shown that for experiments using the yes-no procedure, the area under the (theoretical) operating characteristic curve can be interpreted as the percentage correct on an equivalent unbiased forced-choice test, and that this is true for any continuous underlying distributions. The sampling variability of this area measure has been determined by Pollack and Hsieh (1969). A similar proof for ratingscale experiments is due to Green and Moses (1966). However, using data to estimate the area under a curve of unknown theoretical shape presents difficulties. One expedient has been to connect the points and use the trapezoidal rule (Green & Moses, 1966; Pollack, Norman, & Galanter, 1964). If the true func