Peking Union Medical College Hospital

About: Peking Union Medical College Hospital is a healthcare organization based out in Beijing, China. It is known for research contribution in the topics: Medicine & Population. The organization has 15996 authors who have published 16018 publications receiving 226505 citations.

High Prevalence of Plasmid-Mediated Quinolone Resistance Genes qnr and aac(6′)-Ib-cr in Clinical Isolates of Enterobacteriaceae from Nine Teaching Hospitals in China

Abstract: Quinolone resistance is an emerging problem in China. To investigate the prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6′)-Ib-cr , a total of 265 clinical isolates of Escherichia coli , Klebsiella pneumoniae , Citrobacter freundii , and Enterobacter cloacae with ciprofloxacin MICs of ≥0.25 μg/ml were screened at nine teaching hospitals in China. The qnrA , qnrB , qnrS , and aac(6′)-Ib genes were detected by PCR. The aac(6′)-Ib-cr gene was further identified by digestion with BtsCI and/or direct sequencing. The qnr gene was present in significantly smaller numbers of isolates with cefotaxime MICs of P aac(6′)-Ib-cr was present in 17.0% of the isolates tested, and 7.9% of the isolates carried both the qnr and the aac(6′)-Ib-cr genes. Among the isolates with cefotaxime MICs of ≥2.0 μg/ml, qnr and aac(6 ′ )-Ib-cr were present in 65.7% and 8.6% of E. cloacae isolates, respectively; 65.5% and 21.8% of K. pneumoniae isolates, respectively; 63.3% and 26.7% of C. freundii isolates, respectively; and 6.5% and 16.9% of E. coli isolates, respectively. The 20 transconjugants showed 16- to 128-fold increases in ciprofloxacin MICs, 14 showed 16- to 2,000-fold increases in cefotaxime MICs, and 5 showed 8- to 32-fold increases in cefoxitin MICs relative to those of the recipient due to the cotransmission of bla CTX-M-14 , bla CTX-M-3 , bla DHA-1 , bla SHV-2 , and bla SHV-12 with the qnr and aac(6 ′ )-Ib-cr genes. Southern hybridization analysis showed that these genes were located on large plasmids of different sizes (53 to 193 kb). These findings indicate the high prevalence of qnr and aac(6′)-Ib-cr in members of the family Enterobacteriaceae and the widespread dissemination of multidrug resistance in China.

A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

Abstract: Ding Ma, Xing Xie, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.

Fibroblast Activation Protein-Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT.

Abstract: IgG4-related disease (IgG4-RD) is characterized by lymphoplasmacytic infiltration enriched in IgG4-positive plasma cells and variable degrees of fibrosis with a characteristic storiform pattern. Since fibrosis is an important feature of IgG4-RD, we performed a prospective cohort study to evaluate the performance of 68Ga-FAPI, a recently introduced PET agent targeting fibroblast activation protein, in IgG4-RD. Methods: Twenty-six patients with IgG4-RD were recruited. All patients underwent both 68Ga-FAPI and 18F-FDG PET/CT. The positive rates of the PET/CT scans in the involved organs and the uptake values were compared. Results: In a total of 136 organ involvements in the 26 patients, 68Ga-FAPI PET/CT additionally detected 18/136 (13.2%) organ involvements in 13/26 (50.0%) patients compared with 18F-FDG PET/CT. 68Ga-FAPI PET/CT had a higher positive rate than 18F-FDG PET/CT in detecting involvement in the pancreas, bile duct/liver, and lacrimal gland. 68Ga-FAPI also demonstrated significantly higher uptake than 18F-FDG in the matched disease in the pancreas, bile duct/liver, and salivary gland (P < 0.01). However, lymph node involvements with flip-flop uptake of 18F-FDG were not accumulating 68Ga-FAPI. Conclusion:68Ga-FAPI might be a promising imaging agent for the assessment of IgG4-RD.