Institution
Peking Union Medical College Hospital
Healthcare•Beijing, China•
About: Peking Union Medical College Hospital is a healthcare organization based out in Beijing, China. It is known for research contribution in the topics: Medicine & Population. The organization has 15996 authors who have published 16018 publications receiving 226505 citations.
Topics: Medicine, Population, Cancer, Lung cancer, Internal medicine
Papers published on a yearly basis
Papers
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TL;DR: This finding suggests that preoperative nutritional support is beneficial to patients with an NRS score at least 5 by lowering the complication rate.
296 citations
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TL;DR: It is shown that mutations in acrR are an additional genetic basis for fluoroquinolone resistance, which reduced the level of AcrA in the mutants and partially restored antibiotic susceptibility 1.5- to 6-fold.
Abstract: The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated resistance to a variety of other antibiotics. PCR sequence analysis of the quinolone resistance-determining region of the topoisomerase genes (gyrA/B, parC) revealed three to five mutations known to be associated with fluoroquinolone resistance. Western blot analysis failed to demonstrate overexpression of MarA, and Northern blot analysis did not detect overexpression of soxS RNA in any of the clinical strains. The AcrA protein of the AcrAB multidrug efflux pump was overexpressed in 19 of 30 strains of E. coli tested, and all 19 strains were tolerant to organic solvents. PCR amplification of the complete acrR (regulator/repressor) gene of eight isolates revealed amino acid changes in four isolates, a 9-bp deletion in another, and a 22-bp duplication in a sixth strain. Complementation with a plasmid-borne wild-type acrR gene reduced the level of AcrA in the mutants and partially restored antibiotic susceptibility 1.5- to 6-fold. This study shows that mutations in acrR are an additional genetic basis for fluoroquinolone resistance.
296 citations
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University of Alberta1, University of Toronto2, University Health Network3, Monash University4, Peking Union Medical College Hospital5, Paris Diderot University6, Peking Union Medical College7, The George Institute for Global Health8, University of Paris9, Ghent University Hospital10, Innsbruck Medical University11, Vita-Salute San Raffaele University12, University of California, San Francisco13, Auckland City Hospital14, University of Kentucky15, University College Dublin16, Guy's and St Thomas' NHS Foundation Trust17, United States Department of Veterans Affairs18, French Institute of Health and Medical Research19, Southeast University20, McMaster University21, University Hospital of Lausanne22, London Health Sciences Centre23, University of Münster24
TL;DR: Among critically ill patients with acute kidney injury, an accelerated renal-replacement strategy was not associated with a lower risk of death at 90 days than a standard strategy, and the most effective timing for the initiation of such therapy remains uncertain.
Abstract: Background Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain. Methods We conducted a multinational, randomized, controlled trial involving critically ill patients with severe acute kidney injury. Patients were randomly assigned to receive an accelerated strategy of renal-replacement therapy (in which therapy was initiated within 12 hours after the patient had met eligibility criteria) or a standard strategy (in which renal-replacement therapy was discouraged unless conventional indications developed or acute kidney injury persisted for >72 hours). The primary outcome was death from any cause at 90 days. Results Of the 3019 patients who had undergone randomization, 2927 (97.0%) were included in the modified intention-to-treat analysis (1465 in the accelerated-strategy group and 1462 in the standard-strategy group). Of these patients, renal-replacement therapy was performed in 1418 (96.8%) in the accelerated-strategy group and in 903 (61.8%) in the standard-strategy group. At 90 days, death had occurred in 643 patients (43.9%) in the accelerated-strategy group and in 639 (43.7%) in the standard-strategy group (relative risk, 1.00; 95% confidence interval [CI], 0.93 to 1.09; P = 0.92). Among survivors at 90 days, continued dependence on renal-replacement therapy was confirmed in 85 of 814 patients (10.4%) in the accelerated-strategy group and in 49 of 815 patients (6.0%) in the standard-strategy group (relative risk, 1.74; 95% CI, 1.24 to 2.43). Adverse events occurred in 346 of 1503 patients (23.0%) in the accelerated-strategy group and in 245 of 1489 patients (16.5%) in the standard-strategy group (P Conclusions Among critically ill patients with acute kidney injury, an accelerated renal-replacement strategy was not associated with a lower risk of death at 90 days than a standard strategy. (Funded by the Canadian Institutes of Health Research and others; STARRT-AKI ClinicalTrials.gov number, NCT02568722.).
295 citations
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TL;DR: Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
Abstract: Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model
293 citations
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Peking Union Medical College1, Chinese National Human Genome Center2, Shanghai Jiao Tong University3, Tsinghua University4, Washington University in St. Louis5, Huazhong University of Science and Technology6, Xinjiang Medical University7, Peking Union Medical College Hospital8, Wuhan University9, Academy of Medical Sciences, United Kingdom10, Nanjing Medical University11, Capital Medical University12, Beihua University13, Xi'an Jiaotong University14, Centers for Disease Control and Prevention15, Peking University16, Zhengzhou University17, Shenzhen University18, University of Lübeck19, University Hospitals of Leicester NHS Trust20, University of Leicester21, Broad Institute22, Harvard University23, University of Pennsylvania24
TL;DR: A meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls provides new insights into pathways contributing to the susceptibility for coronary arteries disease in the Chinese Han population.
Abstract: We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
290 citations
Authors
Showing all 16286 results
Name | H-index | Papers | Citations |
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Feng Zhang | 172 | 1278 | 181865 |
Jian Li | 133 | 2863 | 87131 |
Shuai Liu | 129 | 1095 | 80823 |
Jun Yu | 121 | 1174 | 81186 |
Edward M. Brown | 111 | 489 | 44630 |
Qian Wang | 108 | 2148 | 65557 |
Ming Li | 103 | 1669 | 62672 |
Tao Li | 102 | 2483 | 60947 |
Masatoshi Kudo | 100 | 1324 | 53482 |
Christophe Tzourio | 98 | 475 | 53680 |
Yang Xin Fu | 97 | 390 | 33526 |
Michael Q. Zhang | 93 | 378 | 42008 |
Xiang Gao | 92 | 1359 | 42047 |
Jun Li | 90 | 339 | 61485 |
Honglei Chen | 80 | 207 | 83906 |