Institution
RMIT University
Education•Melbourne, Victoria, Australia•
About: RMIT University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 40468 authors who have published 82923 publications receiving 1729499 citations. The organization is also known as: Royal Melbourne Institute of Technology & Melbourne Technical College.
Topics: Population, Health care, Context (language use), Medicine, Mental health
Papers published on a yearly basis
Papers
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TL;DR: Some of the mechanisms responsible for improved skeletal muscle metabolic control and changes in cardiovascular function in response to low‐ volume HIT are reviewed and insight is provided on the utility of low‐volume HIT for improving performance in athletes.
Abstract: Exercise training is a clinically proven, cost-effective, primary intervention that delays and in many cases prevents the health burdens associated with many chronic diseases. However, the precise type and dose of exercise needed to accrue health benefits is a contentious issue with no clear consensus recommendations for the prevention of inactivity-related disorders and chronic diseases. A growing body of evidence demonstrates that high-intensity interval training (HIT)canserveasaneffectivealternatetotraditionalendurance-basedtraining,inducingsimilar or even superior physiological adaptations in healthy individuals and diseased populations, at least when compared on a matched-work basis. While less well studied, low-volume HIT can also stimulate physiological remodelling comparable to moderate-intensity continuous training despite a substantially lower time commitment and reduced total exercise volume. Such findings areimportantgiventhat'lackoftime'remainsthemostcommonlycitedbarriertoregularexercise participation. Here we review some of the mechanisms responsible for improved skeletal muscle metabolic control and changes in cardiovascular function in response to low-volume HIT. We also consider the limited evidence regarding the potential application of HIT to people with, or at risk for, cardiometabolic disorders including type 2 diabetes. Finally, we provide insight on the utility of low-volume HIT for improving performance in athletes and highlight suggestions for future research.
1,362 citations
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TL;DR: The newly revised MNA-SF is a valid nutritional screening tool applicable to geriatric health care professionals with the option of using CC when BMI cannot be calculated and increases the applicability of this rapid screening tool in clinical practice through the inclusion of a “malnourished” category.
Abstract: Objective: To validate a revision of the Mini Nutritional Assessment short-form (MNA®-SF) against the full MNA, a standard tool for nutritional evaluation. Methods: A literature search identified studies that used the MNA for nutritional screening in geriatric patients. The contacted authors submitted original datasets that were merged into a single database. Various combinations of the questions on the current MNA-SF were tested using this database through combination analysis and ROC based derivation of classification thresholds. Results: Twenty-seven datasets (n=6257 participants) were initially processed from which twelve were used in the current analysis on a sample of 2032 study participants (mean age 82.3y) with complete information on all MNA items. The original MNA-SF was a combination of six questions from the full MNA. A revised MNA-SF included calf circumference (CC) substituted for BMI performed equally well. A revised three-category scoring classification for this revised MNA-SF, using BMI and/or CC, had good sensitivity compared to the full MNA. Conclusion: The newly revised MNA-SF is a valid nutritional screening tool applicable to geriatric health care professionals with the option of using CC when BMI cannot be calculated. This revised MNA-SF increases the applicability of this rapid screening tool in clinical practice through the inclusion of a "malnourished" category.
1,352 citations
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TL;DR: This paper explores some of the publicly available international guidelines and introduces the BIM Framework, a research and delivery foundation for industry stakeholders, and identifies and deploys visual knowledge models and a specialised ontology to represent domain concepts and their relations.
1,334 citations
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Erasmus University Medical Center1, University of Gothenburg2, University of Tampere3, Complutense University of Madrid4, King Juan Carlos University5, Memorial Sloan Kettering Cancer Center6, university of lille7, RMIT University8, Helsinki University Central Hospital9, Queen Mary University of London10
TL;DR: In this update the ERSPC confirms a substantial reduction in prostate cancer mortality attributable to testing of PSA, with a substantially increased absolute effect at 13 years compared with findings after 9 and 11 years.
1,288 citations
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TL;DR: A review of historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery, and a discussion of how natural product chemistry has resulted in the identification of many drug candidates are highlighted.
Abstract: Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
1,282 citations
Authors
Showing all 40792 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kari Stefansson | 206 | 794 | 174819 |
Martin White | 196 | 2038 | 232387 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Vilmundur Gudnason | 159 | 837 | 123802 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Wei Zheng | 151 | 1929 | 120209 |
Ashok Kumar | 151 | 5654 | 164086 |
Timothy P. Hughes | 145 | 831 | 91357 |
John D. Potter | 137 | 795 | 75310 |
Dimitrios Trichopoulos | 135 | 818 | 84992 |
Simon C. Watkins | 135 | 950 | 68358 |
Eiliv Lund | 133 | 856 | 83087 |
Albert V. Smith | 132 | 411 | 104809 |
Frank Caruso | 131 | 641 | 61748 |
Jeff A. Sloan | 129 | 656 | 65308 |