Institution
Saarland University
Education•Saarbrücken, Germany•
About: Saarland University is a education organization based out in Saarbrücken, Germany. It is known for research contribution in the topics: Population & Medicine. The organization has 19555 authors who have published 39678 publications receiving 1109295 citations. The organization is also known as: University of the Saarland & Universität des Saarlandes.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Eosinophils maintain a high TF expression during maturation, providing a main source of preformed TF in blood, which might be relevant for the thrombogenesis promoted by hypereos inophilic conditions.
215 citations
••
Memorial Sloan Kettering Cancer Center1, University of Lyon2, University of Amsterdam3, University of Melbourne4, Roswell Park Cancer Institute5, Saarland University6, Lille University of Science and Technology7, Stanford University8, Genentech9, European Organisation for Research and Treatment of Cancer10, Mayo Clinic11, Fox Chase Cancer Center12, University of Bologna13, University of Copenhagen14, Charles University in Prague15, Janssen Pharmaceutica16, Harvard University17, University of Texas MD Anderson Cancer Center18, Hackensack University Medical Center19, Cleveland Clinic20, Princess Margaret Cancer Centre21, Ludwig Maximilian University of Munich22, National Institutes of Health23, University Hospital Centre Zagreb24, Celgene25, Fred Hutchinson Cancer Research Center26, University of Plymouth27, University of California, Los Angeles28, University of Michigan29, Columbia University30, NewYork–Presbyterian Hospital31, University of Pennsylvania32
TL;DR: It is demonstrated that assessment of tumor burden in lymphoma clinical trials can use the sum of longest diameters of a maximum of three target lesions, and a new lymphoma response criteria (RECIL 2017) was developed.
215 citations
••
TL;DR: It is shown that affect bursts, presented without context, can convey a clearly identifiable emotional meaning and the influence of the segmental structure on emotion recognition, as opposed to prosody and voice quality, is investigated.
215 citations
••
TL;DR: Direct inhibition of miR-21 by antagomir-21 prevented fibrosis of the atrial myocardium post-myocardial infarction and signalling in vivo were prevented by long-term treatment of the mice with statins.
Abstract: Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2.5-fold increased expression of miR-21 compared to matched LA of patients in sinus rhythm. Increased miR-21 expression correlated positively with atrial collagen content and was associated with a reduced protein expression of Spry1 and increased expression of connective tissue growth factor (CTGF), lysyl oxidase and Rac1-GTPase. Neonatal cardiac fibroblasts treated with angiotensin II (AngII) or CTGF showed an increased miR-21 and decreased Spry1 expression. Pretreatment with an inhibitor of Rac1 GTPase, NSC23766, reduced the AngII-induced upregulation of miR-21. A small molecule inhibitor of lysyl oxidase, BAPN, prevented the AngII as well as the CTGF-induced miR-21 expression. Transgenic mice with cardiac overexpression of Rac1, which develop spontaneous AF and atrial fibrosis with increasing age, showed upregulation of miR-21 expression associated with reduced Spry1 expression. miR-21 expression and signalling in vivo were prevented by long-term treatment of the mice with statins. Direct inhibition of miR-21 by antagomir-21 prevented fibrosis of the atrial myocardium post-myocardial infarction. Left atria of patients with atrial fibrillation are characterized by upregulation of miR-21 und reduced expression of Spry1. Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium.
215 citations
••
TL;DR: This communication introduces a comparatively simple way how to extend active contours to multiple regions keeping the familiar quality of the two-phase case and suggests a strategy to determine the optimum number of regions.
Abstract: The popularity of level sets for segmentation is mainly based on the sound and convenient treatment of regions and their boundaries. Unfortunately, this convenience is so far not known from level set methods when applied to images with more than two regions. This communication introduces a comparatively simple way how to extend active contours to multiple regions keeping the familiar quality of the two-phase case. We further suggest a strategy to determine the optimum number of regions as well as initializations for the contours
215 citations
Authors
Showing all 19735 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Schmitt | 134 | 2007 | 114667 |
Bernt Schiele | 130 | 568 | 70032 |
Peter Walter | 126 | 841 | 71580 |
David Zurakowski | 117 | 1168 | 55806 |
Kurt Binder | 114 | 1248 | 65308 |
Franz Hofmann | 113 | 471 | 49938 |
Bernd Nilius | 112 | 496 | 44812 |
Hans-Peter Seidel | 112 | 1213 | 51080 |
Stefan Zeuzem | 108 | 1027 | 50529 |
Rolf Müller | 104 | 905 | 50027 |
Samuel Klein | 101 | 363 | 46578 |
Michael Bauer | 100 | 1052 | 56841 |
Ulman Lindenberger | 100 | 554 | 41956 |
Thomas Brox | 99 | 329 | 94431 |
Elisabeth Kremmer | 99 | 413 | 34720 |