Institution
Saarland University
Education•Saarbrücken, Germany•
About: Saarland University is a education organization based out in Saarbrücken, Germany. It is known for research contribution in the topics: Population & Medicine. The organization has 19555 authors who have published 39678 publications receiving 1109295 citations. The organization is also known as: University of the Saarland & Universität des Saarlandes.
Papers published on a yearly basis
Papers
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TL;DR: An intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone, cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold, suggesting an impaired hypothalamic regulation.
Abstract: An imbalance between the overall strain experienced during exercise training and the athlete's tolerance of such effort may induce overreaching or overtraining syndrome. Overtraining syndrome is characterised by diminished sport-specific physical performance, accelerated fatiguability and subjective symptoms of stress. Overtraining is feared by athletes yet there is a lack of objective parameters suitable for its diagnosis and prevention. In addition to the determination of substrates (e.g. lactate, ammonia and urea) and enzymes (e.g. creatine kinase), the possibilities for monitoring of training by measuring hormonal levels in blood are currently being investigated. Endogenous hormones are essential for physiological reactions and adaptations during physical work and influence the recovery phase after exercise by modulating anabolic and catabolic processes. Testosterone and cortisol are playing a significant role in metabolism of protein as well as carbohydrate metabolism. Both are competitive agonists at the receptor level of muscular cells. The testosterone/cortisol ratio is used as an indication of the anabolic/catabolic balance. This ratio decreases in relation to the intensity and duration of physical exercise, as well as during periods of intense training or repetitive competition, and can be reversed by regenerative measures. Correlations have been noted with the training-induced changes of strength. However, it seems more likely that the testosterone/cortisol ratio indicates the actual physiological strain in training, rather than overtraining syndrome. The sympatho-adrenergic system might be involved in the pathogenesis of overtraining. Overtraining appears as a disturbed autonomic regulation, which in its parasympathicotonic form shows a diminished maximal secretion of catecholamines, combined with an impaired full mobilisation of anaerobic lactic reserves. This is supposed to lead to decreased maximal blood lactate levels and maximal performance. Free plasma adrenaline (epinephrine) and noradrenaline (norepinephrine) may provide additional information for the monitoring of endurance training. While prolonged aerobic exercise conducted at intensities below the individual anaerobic threshold lead to a moderate rise of sympathetic activity, workloads exceeding this threshold are characterised by a disproportionate increase in the levels of catecholamines. In addition, psychological stress during competitive events is characterised by a higher catecholamines to lactate ratio in comparison with training exercise sessions. Thus, the frequency of training sessions with higher anaerobic lactic demands or of competition, should be carefully limited in order to prevent overtraining syndrome. In the state of overtraining syndrome and overreaching, respectively, an intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone), cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold.(ABSTRACT TRUNCATED AT 400 WORDS)
449 citations
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TL;DR: A highly optimized implementation of a ray tracer that improves performance by more than an order of magnitude compared to currently available ray tracers is presented and it is shown that this software implementation can challenge and even outperform high-end graphics hardware in interactive rendering performance for complex environments.
Abstract: For almost two decades researchers have argued that ray tracing will eventually become faster than the rasterization technique that completely dominates todays graphics hardware. However, this has not happened yet. Ray tracing is still exclusively being used for off-line rendering of photorealistic images and it is commonly believed that ray tracing is simply too costly to ever challenge rasterization-basedalgorithms for interactive use. However, there is hardly any scientific analysis that supports either point of view. In particular there is no evidence of where the crossover point might be, at which ray tracing would eventually become faster, or if such a point does exist at all. This paper provides several contributions to this discussion: We fir st present a highly optimized implementationof a ray tracer that improves performance by more than an order of magnitude compared to currently available ray tracers. The new algorithm makes better use of computational resources such as caches and SIMD instructions and better exploits image and object space coherence. Secondly, we show that this software implementation can challenge and even outperform high-end graphics hardware in interactive rendering performance for complex environments. We also provide an brief overview of the benefits of ray tracing over rasterization algorithms and point out the potential of interactive ray tracing both in hardware and software.
448 citations
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University of Wisconsin-Madison1, Ludwig Maximilian University of Munich2, Hannover Medical School3, French Institute of Health and Medical Research4, British Heart Foundation5, RWTH Aachen University6, Saarland University7, University of Glasgow8, Charité9, University of Melbourne10, University of Alabama at Birmingham11, Thermo Fisher Scientific12, University College Dublin13, Harvard University14, Joslin Diabetes Center15, University of Modena and Reggio Emilia16, University of Picardie Jules Verne17, University of Regensburg18, The Heart Research Institute19, Leipzig University20, Department of Urology, University of Virginia21, Mahidol University22
TL;DR: The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.
447 citations
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TL;DR: It is shown that characterizing the causal relationship between significant events is an important but non-trivial aspect for understanding the behavior of distributed programs.
Abstract: The paper shows that characterizing the causal relationship between significant events is an important but non-trivial aspect for understanding the behavior of distributed programs. An introduction to the notion of causality and its relation to logical time is given; some fundamental results concerning the characterization of causality are presented. Recent work on the detection of causal relationships in distributed computations is surveyed. The issue of observing distributed computations in a causally consistent way and the basic problems of detecting global predicates are discussed. To illustrate the major difficulties, some typical monitoring and debugging approaches are assessed, and it is demonstrated how their feasibility is severely limited by the fundamental problem to master the complexity of causal relationships.
446 citations
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TL;DR: Evidence is provided that TRPM3 functions as a chemo- and thermosensor in the somatosensory system and an unanticipated role for TR PM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat is revealed.
445 citations
Authors
Showing all 19735 results
Name | H-index | Papers | Citations |
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Michael Schmitt | 134 | 2007 | 114667 |
Bernt Schiele | 130 | 568 | 70032 |
Peter Walter | 126 | 841 | 71580 |
David Zurakowski | 117 | 1168 | 55806 |
Kurt Binder | 114 | 1248 | 65308 |
Franz Hofmann | 113 | 471 | 49938 |
Bernd Nilius | 112 | 496 | 44812 |
Hans-Peter Seidel | 112 | 1213 | 51080 |
Stefan Zeuzem | 108 | 1027 | 50529 |
Rolf Müller | 104 | 905 | 50027 |
Samuel Klein | 101 | 363 | 46578 |
Michael Bauer | 100 | 1052 | 56841 |
Ulman Lindenberger | 100 | 554 | 41956 |
Thomas Brox | 99 | 329 | 94431 |
Elisabeth Kremmer | 99 | 413 | 34720 |