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Institution

Saarland University

EducationSaarbrücken, Germany
About: Saarland University is a education organization based out in Saarbrücken, Germany. It is known for research contribution in the topics: Population & Medicine. The organization has 19555 authors who have published 39678 publications receiving 1109295 citations. The organization is also known as: University of the Saarland & Universität des Saarlandes.


Papers
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Journal ArticleDOI
TL;DR: An intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone, cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold, suggesting an impaired hypothalamic regulation.
Abstract: An imbalance between the overall strain experienced during exercise training and the athlete's tolerance of such effort may induce overreaching or overtraining syndrome. Overtraining syndrome is characterised by diminished sport-specific physical performance, accelerated fatiguability and subjective symptoms of stress. Overtraining is feared by athletes yet there is a lack of objective parameters suitable for its diagnosis and prevention. In addition to the determination of substrates (e.g. lactate, ammonia and urea) and enzymes (e.g. creatine kinase), the possibilities for monitoring of training by measuring hormonal levels in blood are currently being investigated. Endogenous hormones are essential for physiological reactions and adaptations during physical work and influence the recovery phase after exercise by modulating anabolic and catabolic processes. Testosterone and cortisol are playing a significant role in metabolism of protein as well as carbohydrate metabolism. Both are competitive agonists at the receptor level of muscular cells. The testosterone/cortisol ratio is used as an indication of the anabolic/catabolic balance. This ratio decreases in relation to the intensity and duration of physical exercise, as well as during periods of intense training or repetitive competition, and can be reversed by regenerative measures. Correlations have been noted with the training-induced changes of strength. However, it seems more likely that the testosterone/cortisol ratio indicates the actual physiological strain in training, rather than overtraining syndrome. The sympatho-adrenergic system might be involved in the pathogenesis of overtraining. Overtraining appears as a disturbed autonomic regulation, which in its parasympathicotonic form shows a diminished maximal secretion of catecholamines, combined with an impaired full mobilisation of anaerobic lactic reserves. This is supposed to lead to decreased maximal blood lactate levels and maximal performance. Free plasma adrenaline (epinephrine) and noradrenaline (norepinephrine) may provide additional information for the monitoring of endurance training. While prolonged aerobic exercise conducted at intensities below the individual anaerobic threshold lead to a moderate rise of sympathetic activity, workloads exceeding this threshold are characterised by a disproportionate increase in the levels of catecholamines. In addition, psychological stress during competitive events is characterised by a higher catecholamines to lactate ratio in comparison with training exercise sessions. Thus, the frequency of training sessions with higher anaerobic lactic demands or of competition, should be carefully limited in order to prevent overtraining syndrome. In the state of overtraining syndrome and overreaching, respectively, an intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone), cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold.(ABSTRACT TRUNCATED AT 400 WORDS)

449 citations

Journal ArticleDOI
TL;DR: A highly optimized implementation of a ray tracer that improves performance by more than an order of magnitude compared to currently available ray tracers is presented and it is shown that this software implementation can challenge and even outperform high-end graphics hardware in interactive rendering performance for complex environments.
Abstract: For almost two decades researchers have argued that ray tracing will eventually become faster than the rasterization technique that completely dominates todays graphics hardware. However, this has not happened yet. Ray tracing is still exclusively being used for off-line rendering of photorealistic images and it is commonly believed that ray tracing is simply too costly to ever challenge rasterization-basedalgorithms for interactive use. However, there is hardly any scientific analysis that supports either point of view. In particular there is no evidence of where the crossover point might be, at which ray tracing would eventually become faster, or if such a point does exist at all. This paper provides several contributions to this discussion: We fir st present a highly optimized implementationof a ray tracer that improves performance by more than an order of magnitude compared to currently available ray tracers. The new algorithm makes better use of computational resources such as caches and SIMD instructions and better exploits image and object space coherence. Secondly, we show that this software implementation can challenge and even outperform high-end graphics hardware in interactive rendering performance for complex environments. We also provide an brief overview of the benefits of ray tracing over rasterization algorithms and point out the potential of interactive ray tracing both in hardware and software.

448 citations

Journal ArticleDOI
TL;DR: The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.

447 citations

Journal ArticleDOI
TL;DR: It is shown that characterizing the causal relationship between significant events is an important but non-trivial aspect for understanding the behavior of distributed programs.
Abstract: The paper shows that characterizing the causal relationship between significant events is an important but non-trivial aspect for understanding the behavior of distributed programs. An introduction to the notion of causality and its relation to logical time is given; some fundamental results concerning the characterization of causality are presented. Recent work on the detection of causal relationships in distributed computations is surveyed. The issue of observing distributed computations in a causally consistent way and the basic problems of detecting global predicates are discussed. To illustrate the major difficulties, some typical monitoring and debugging approaches are assessed, and it is demonstrated how their feasibility is severely limited by the fundamental problem to master the complexity of causal relationships.

446 citations

Journal ArticleDOI
12 May 2011-Neuron
TL;DR: Evidence is provided that TRPM3 functions as a chemo- and thermosensor in the somatosensory system and an unanticipated role for TR PM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat is revealed.

445 citations


Authors

Showing all 19735 results

NameH-indexPapersCitations
Michael Schmitt1342007114667
Bernt Schiele13056870032
Peter Walter12684171580
David Zurakowski117116855806
Kurt Binder114124865308
Franz Hofmann11347149938
Bernd Nilius11249644812
Hans-Peter Seidel112121351080
Stefan Zeuzem108102750529
Rolf Müller10490550027
Samuel Klein10136346578
Michael Bauer100105256841
Ulman Lindenberger10055441956
Thomas Brox9932994431
Elisabeth Kremmer9941334720
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202358
2022365
20212,302
20202,194
20191,994
20181,908