Institution
Solvay
Company•Brussels, Belgium•
About: Solvay is a company organization based out in Brussels, Belgium. It is known for research contribution in the topics: Catalysis & Polymer. The organization has 6083 authors who have published 7004 publications receiving 105745 citations.
Topics: Catalysis, Polymer, Polymerization, Alkyl, Aqueous solution
Papers published on a yearly basis
Papers
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30 Jun 1997TL;DR: In this article, the VDF polymerization process, optionally modified with small amounts of one or more fluoro-containing comonomers, is carried out in the presence of a microemulsion comprising a (per)fluoropolyether having neutral end groups, having number average molecular weight between 400 and 3000, and a surfactant based on perfluoropolymers with salified acid end groups.
Abstract: VDF polymerization process, optionally modified with small amounts of one or more fluoro-containing comonomers, carried out in the presence of a microemulsion comprising a (per)fluoropolyether having neutral end groups, having number average molecular weight between 400 and 3000, and a surfactant based on perfluoropolyethers with salified acid end groups, said surfactant having a number molecular weight Mn comprised between 400-600 and having a distribution of molecular weights such that fractions having a number average molecular weight higher than 700 are not present, or are in amount less than 5% by weight.
58 citations
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TL;DR: The present clinical study was a randomized, endpoint-blind, parallel group study in elderly subjects aged 61 years and older to investigate the safety and immunogenicity of these vaccines as compared to a standard influenza vaccine Invivac (Solvay Pharmaceuticals).
57 citations
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TL;DR: These data provide the first evidence that NAC 5-HT2A and 5- HT2C receptors are critical for the expression of cocaine-induced neuroplasticity following protracted withdrawal, which has relevance for their therapeutic utility in the treatment of addiction.
Abstract: Rationale
The serotonin 5-HT2A and 5-HT2C receptors regulate the capacity of acute cocaine to augment behavior and monoamine levels within the nucleus accumbens (NAC), a brain region involved in cocaine’s addictive and psychotogenic properties.
57 citations
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13 Jan 1992TL;DR: An aerosol generator useful as an atomizer for controllably and reproduci producing wet or dry aerosols for inhalation studies is described in this article, including a nebulizer for producing an aerosol from a liquid and an air stream, a liquid dosing device such as a step dosing pump, an apparatus such as the mass flow controller for regulating the flow of air stream to the neubilizer to provide an amount needed to atomize the liquid, and optionally to dilute the resulting aerosol, a conduit for conveying the aerosol formed in
Abstract: An aerosol generator useful as an atomizer for controllably and reproduci producing wet or dry aerosols for inhalation studies, including a nebulizer for producing an aerosol from a liquid and an air stream, a liquid dosing device such as a step dosing pump for controllably feeding a liquid to be atomized to the neubilizer, an apparatus such as a mass flow controller for regulating the flow of an air stream to the nebulizer to provide an amount needed to atomize the liquid, and optionally to dilute the resulting aerosol, a conduit for conveying the aerosol formed in the nebulizer to an aerosol exposure chamber, a measuring device such as a light-scattering diffusion photometer into which a sample of the aerosol is introduced for determining the concentration of the aerosol, and a control unit for controlling the liquid supply device and the adjustable air supply to produce an aerosol having a predetermined desired concentration; the control unit being operated either manually or by a computer responsive to measured values determined by the measuring device.
57 citations
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TL;DR: In vitro and in vivo studies revealed that 45c has favorable pharmacokinetic properties and a high CNS-plasma ratio and molecular modeling studies showed that the bifunctional activity of 45c can be explained by its ability to adopt two different conformations fitting either the dopamine D(2) receptor pharmacophore or the serotonin transporter pharmacophores.
Abstract: A series of novel bicyclic 1-heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines was synthesized and evaluated on binding to dopamine D2 receptors and serotonin reuptake sites. This class of compounds proved to be potent in vitrodopamine D2 receptor antagonists and in addition were highly active as serotonin reuptake inhibitors. Some key representatives showed potent pharmacological in vivo activities after oral dosing in both the antagonism of apomorphine-induced climbing and the potentiation of 5-HTP-induced behavior in mice. On the basis of the preclinical data, 8-{4-[3-(5-fluoro-1H-indol-3-yl)propyl]piperazin-1-yl}-4H-benzo[1,4]oxazin-(R)-2-methyl-3-one (45c, SLV314) was selected for clinical development. In vitro and in vivo studies revealed that 45c has favorable pharmacokinetic properties and a high CNS−plasma ratio. Molecular modeling studies showed that the bifunctional activity of 45c can be explained by its ability to adopt two different conformations fitting either the dopamine D2 receptor pharma...
57 citations
Authors
Showing all 6091 results
Name | H-index | Papers | Citations |
---|---|---|---|
Adi F. Gazdar | 157 | 776 | 104116 |
Mohammad Khaja Nazeeruddin | 129 | 646 | 85630 |
Jack P. Antel | 105 | 519 | 43950 |
Philippe Dubois | 101 | 1098 | 48086 |
Enrico Drioli | 95 | 987 | 37962 |
Martin Winter | 93 | 751 | 45506 |
Gian F. Giudice | 93 | 264 | 50392 |
Johannes Hebebrand | 91 | 581 | 38408 |
Michael Graetzel | 89 | 360 | 43269 |
Andrew J. Martin | 84 | 819 | 36203 |
Alan D. Rogol | 81 | 461 | 24865 |
Anthony L. Spek | 81 | 1090 | 59190 |
William J. Tremaine | 80 | 282 | 24233 |
Marc Henneaux | 76 | 411 | 27840 |
Stephen Lam | 76 | 413 | 20693 |