Institution
Solvay
Company•Brussels, Belgium•
About: Solvay is a company organization based out in Brussels, Belgium. It is known for research contribution in the topics: Catalysis & Polymer. The organization has 6083 authors who have published 7004 publications receiving 105745 citations.
Topics: Catalysis, Polymer, Polymerization, Alkyl, Aqueous solution
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors describe the functional characterization of the serotonin transporter (SERT) knockout rat model, that is generated by N-ethyl-N-nitrosurea (ENU)-driven target-selected mutagenesis.
239 citations
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238 citations
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TL;DR: In this paper, the authors proposed some scenarios to pursue dark matter searches at the LHC in a fairly model-independent way, and determined the masses that lead to the correct thermal relic density including, for therst time, strong Sommerfeld corrections taking into account colour decomposition.
Abstract: We propose some scenarios to pursue dark matter searches at the LHC in a fairly model-independent way. Therst benchmark case is dark matter co-annihilations with coloured particles (gluinos or squarks being special examples). We determine the masses that lead to the correct thermal relic density including, for therst time, strong Sommerfeld corrections taking into account colour decomposition. In the second bench- mark case we consider dark matter that couples to SM particles via the Z or the Higgs. We determine the couplings allowed by present experiments and discuss future prospects. Finally we present the case of dark matter that freezes out via decays and apply our results to invisible Z and Higgs decays.
232 citations
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TL;DR: Results indicate that modulation of 5-HT function within the mPFC via distinct receptors can enhance performance on the 5CSRT, and suggest a mechanism by which serotonergic agents improve cognitive function.
Abstract: The central serotonergic systems are a major target for drugs used to treat neuropsychiatric disorders such as depression and schizophrenia in which disruption of frontal cortex function has been implicated. However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour. To investigate the roles of 5-HT1A and 5-HT2A receptors in mPFC on performance of the five-choice serial reaction time task (5CSRT), which assesses visuospatial attention, impulsivity and motivational processes. Following training on the 5CSRT, rats were implanted with bilateral guide cannulae aimed at the mPFC. Rats received intra-mPFC infusions of either 8-OH-DPAT (10, 30 and 100 ng) or M100907 (30, 100 and 300 ng) according to a Latin square design. Both 8-OH-DPAT and M100907 selectively enhanced accuracy of target detection. When the stimulus duration was shortened, infusions of 8-OH-DPAT continued to improve accuracy, whereas M100907 decreased premature responding and omissions, thus partly dissociating the effects of these two compounds. Similar effects were obtained following systemic administration of M100907 and 8-OH-DPAT. The effects of 8-OH-DPAT were blocked by the 5-HT1A antagonist WAY 100635, at a dose that itself had no significant effects on behaviour. These results indicate that modulation of 5-HT function within the mPFC via distinct receptors can enhance performance on the 5CSRT. These findings suggest a mechanism by which serotonergic agents improve cognitive function, which may be relevant to their therapeutic benefit in the treatment of neuropsychiatric disorders.
230 citations
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TL;DR: The findings support the current policy of the World Health Organization (WHO), which is to base worldwide influenza virus surveillance on results predominantly obtained by antigenic analyses of influenza virus isolates with ferret antisera in HI tests.
Abstract: The success of influenza vaccination depends largely on the antigenic match between the influenza vaccine strains and the virus strains actually circulating during the season. In the past, this match has proved to be satisfactory in most seasons. In the 1997/1998 season, however, hemagglutination inhibition (HI) assays with ferret antisera indicated a considerable mismatch between the H3N2 vaccine component and the most prevalent epidemic influenza A(H3N2) virus. The results from antigenic analyses using pre- and postvaccination serum samples from volunteers of various ages, including residents of nursing homes who were more than 60 years of age, were in good agreement with the results obtained with ferret antisera. Homologous serum antibody responses to the H3N2 vaccine component as well as the cross-reactivity of the induced antibodies to the epidemic H3N2 strain, declined with increasing age of the vaccinees. As a consequence of these two effects, 84% of the vaccinees over 75 years of age did not develop HI antibody titers >/= 40 against the major H3N2 virus variant of 1997/1998, suggesting that they were not protected against infection with this virus variant. These findings support the current policy of the World Health Organization (WHO), which is to base worldwide influenza virus surveillance on results predominantly obtained by antigenic analyses of influenza virus isolates with ferret antisera in HI tests. If an antigenic mismatch is observed, the protective efficacy of the vaccine, especially for the elderly, may be insufficient. The observations also support the current policy to include the elderly in serologic efficacy trials.
229 citations
Authors
Showing all 6091 results
Name | H-index | Papers | Citations |
---|---|---|---|
Adi F. Gazdar | 157 | 776 | 104116 |
Mohammad Khaja Nazeeruddin | 129 | 646 | 85630 |
Jack P. Antel | 105 | 519 | 43950 |
Philippe Dubois | 101 | 1098 | 48086 |
Enrico Drioli | 95 | 987 | 37962 |
Martin Winter | 93 | 751 | 45506 |
Gian F. Giudice | 93 | 264 | 50392 |
Johannes Hebebrand | 91 | 581 | 38408 |
Michael Graetzel | 89 | 360 | 43269 |
Andrew J. Martin | 84 | 819 | 36203 |
Alan D. Rogol | 81 | 461 | 24865 |
Anthony L. Spek | 81 | 1090 | 59190 |
William J. Tremaine | 80 | 282 | 24233 |
Marc Henneaux | 76 | 411 | 27840 |
Stephen Lam | 76 | 413 | 20693 |