Institution
Tabriz University of Medical Sciences
Education•Tabriz, Iran•
About: Tabriz University of Medical Sciences is a education organization based out in Tabriz, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 11499 authors who have published 17525 publications receiving 241099 citations.
Topics: Population, Cancer, Medicine, Solubility, Randomized controlled trial
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, a bionanocomposite film based on whey protein isolate (WPI), cellulose nanofibers (CNFs), titanium dioxide (TiO2) nanoparticles and rosemary essential oil (REO) was prepared by casting/evaporation method and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR).
145 citations
••
TL;DR: The main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-Angiogenesis-based targeted therapies are reviewed.
145 citations
••
TL;DR: A comprehensive approach to indicating the activity of Th 17 cells in tumor progression could help in the planning of new therapeutic approaches specially targeting Th17 cells in cancer.
145 citations
••
TL;DR: This review aims to introduce the most recent advances made in nanocarrier mediated targeting of tumor hypoxia and details novel nanosystems proposed to modulate tumor Hypoxia through tumor oxygenation.
Abstract: Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis, metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside the tumors significantly hinder delivery of therapeutic agents. The low oxygen tension results in resistance to the current applied anti-cancer therapeutics including radiotherapy, chemotherapy, and photodynamic therapy, the efficacy of which is firmly tied to the level of tumor oxygen supply. However, emerging data indicate that nanocarriers/nanodrugs can offer substantial benefits to improve the efficacy of current therapeutics, through modulation of tumor hypoxia. This review aims to introduce the most recent advances made in nanocarrier mediated targeting of tumor hypoxia. The first part is dedicated to the approaches by which nanocarriers could be designed to target/leverage hypoxia. These approaches include i) inhibiting Hypoxia Inducer Factor (HIF-1α); ii) hypoxia activated prodrugs/linkers; and iii) obligate anaerobe mediated targeting of tumor hypoxia. The second part, details novel nanosystems proposed to modulate tumor hypoxia through tumor oxygenation. These methods seek to lessen tumor hypoxia through vascular normalization, or reoxygenation therapy. The reoxygenation of tumor could be accomplished by: i) generation of oxygen filled nanocarriers; ii) natural/artificial oxygen nanocarriers; and iii) oxygen generators. The efficacy of each approach and their potential in cancer therapy is further discussed.
144 citations
••
TL;DR: The selected optimal microcapsules revealed intense red color over the time of storage, implying the effectiveness of the method chosen to preserve anthocyanins, particularly under harsh processing and storage conditions.
143 citations
Authors
Showing all 11569 results
Name | H-index | Papers | Citations |
---|---|---|---|
Theo Vos | 156 | 502 | 186409 |
Derrick A Bennett | 90 | 233 | 120764 |
Mohammad Abdollahi | 90 | 1045 | 35531 |
Albert Gjedde | 85 | 548 | 28653 |
Nassim Kamar | 73 | 628 | 20442 |
Nima Rezaei | 72 | 1215 | 26295 |
Alireza Khataee | 68 | 525 | 20805 |
William E. Acree | 66 | 958 | 21196 |
Mohammad Athar | 63 | 329 | 14384 |
Amir H. Mohammadi | 62 | 698 | 16044 |
Ali Montazeri | 61 | 625 | 17494 |
Ali Nokhodchi | 55 | 322 | 9087 |
Muhammad Naveed | 54 | 346 | 10376 |
Behrooz Z. Alizadeh | 52 | 189 | 13793 |
Mohammad Reza Zali | 51 | 804 | 12541 |