Showing papers by "Tabriz University of Medical Sciences published in 2016"
TL;DR: This review will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.
711 citations
TL;DR: In this review, the main applications and liposome-based commercial products that are currently used in the medical field are summarized.
Abstract: Liposomes provide an established basis for the sustainable development of different commercial products for treatment of medical diseases by the smart delivery of drugs. The industrial applications include the use of liposomes as drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers/carriers in medical diagnostics and analytical biochemistry, solubilizers for various ingredients as well as support matrices for various ingredients and penetration enhancers in cosmetics.In this review, we summarize the main applications and liposome-based commercial products that are currently used in the medical field.
491 citations
TL;DR: In this review, some important applications of gold nanoparticles are explained, including those as sensing, image enhancement, and delivery agents in medicine.
Abstract: Nanoparticles are the simplest form of structures with sizes in the nanometer (nm) range. In principle any collection of atoms bonded together with a structural radius of 100 nm can be considered nano particles. Nanotechnology off ers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer scales, and is expected to have a revolutionary impact on biology and medicine. Among the approaches for exploiting nanotechnology in medicine, nanoparticles off er some unique advantages as sensing, image enhancement, and delivery agents. Several varieties of nanoparticles with biomedical relevance are available including, polymeric nanoparticles, metal nanoparticles, liposomes, micelles, quantum dots, dendrimers, and nanoassemblies. To further the application of nanoparticles in disease diagnosis and therapy, it is important that the systems are biocompatible and capable of being functionalized for recognition of specifi c target sites in the body after systemic administration. In this review, we have explained some important applications of gold nanoparticles.
392 citations
TL;DR: The antibacterial activity of as-prepared ZnONPs was investigated against several bacteria such as Listeria monocytogenes, Escherichia coli, Salmonella typhimurium and more.
241 citations
TL;DR: Several popular methods including co-precipitation, microemulsion, thermal decomposition, solvothermal, sonochemical, microwave-assisted, chemical vapor deposition, combustion, carbon arc, and laser pyrolysis are reported for the synthesis of magnetic nanoparticles.
Abstract: The synthesis of different kinds of magnetic nanoparticles (MNPs) has attracted much attention. During the last few years, a large portion of the articles published about MNPs have described efficient routes to attain shape-controlled and highly stable MNPs with narrow size distribution. In this review, we have reported several popular methods including co-precipitation, microemulsion, thermal decomposition, solvothermal, sonochemical, microwave-assisted, chemical vapor deposition, combustion, carbon arc, and laser pyrolysis, for the synthesis of magnetic nanoparticles.
238 citations
TL;DR: This review covers recent advances in the synthesis of gold nanoparticles, which have gathered extensive attention due to their uncommon properties and promising applications in photonics, electronics, biochemical sensing, and imaging.
Abstract: Metal nanoparticles, such as nanoparticles synthesized using gold, have numerous uncommon chemical and physical properties due to the effects of their quantum size and their large surface area, in comparison with other metal atoms or bulk metal. Gold nanoparticles (GNPs), in particular, are very attractive because of their size and shape-dependent properties. Metal nanoparticles have gathered extensive attention due to their uncommon properties and promising applications in photonics, electronics, biochemical sensing, and imaging. This review covers recent advances in the synthesis of GNPs.
174 citations
TL;DR: The association between the development of oral cancer in potentially malignant oral lesions with chronic periodontitis, chronic Porphyromonas gingivalis, Fusobacterium nucleatum, candida, other microbes and described mechanisms which may be involved in these carcinoma are discussed.
172 citations
TL;DR: The results of fluorescence spectroscopy indicated that the fluorescence intensity of BSA was decreased considerably upon the addition of glutathione through a static quenching mechanism, and hydrogen bonding and van der Waals forces were the main interactions in the binding ofglutathione to BSA and the stabilization of the complex.
160 citations
TL;DR: Electrospinning or electrostatic spinning shares characteristics of both electrospraying and conventional solution dry spinning of fibers, which makes the process particularly suited for the production of fibers using large and complex molecules.
Abstract: Electrospinning uses an electrical charge to draw very fine (typically on the micro or nano scale) fibers from a liquid. Electrospinning or electrostatic spinning shares characteristics of both electrospraying and conventional solution dry spinning of fibers. The method does not need the use of coagulation chemistry or high temperatures to produce solid threads from solution. This makes the process particularly suited for the production of fibers using large and complex molecules. Because the full potential of biomaterials being used in various applications, field of nanofibers have involved considerable interest in biotechnology and medicine and there has been fast development in this area in recent years.
155 citations
05 Dec 2016
TL;DR: In order to improve the therapeutic outcomes of CNS drug transfer and targeted delivery, the discriminatory permeability of BBB needs to be taken under control.
Abstract: Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely depends upon the safe drug delivery into the brain parenchyma. However, due to the robust blockade function of the blood-brain barrier (BBB), drug transport into the brain is selectively controlled by the BBB formed by brain capillary endothelial cells and supported by astrocytes and pericytes. Methods: In the current study, we have reviewed the most recent literature on the subject to provide an insight upon the role and impacts of BBB on brain drug delivery and targeting. Results: All drugs, either small molecules or macromolecules, designated to treat brain diseases must adequately cross the BBB to provide their therapeutic properties on biological targets within the central nervous system (CNS). However, most of these pharmaceuticals do not sufficiently penetrate into CNS, failing to meet the intended therapeutic outcomes. Most lipophilic drugs capable of penetrating BBB are prone to the efflux functionality of BBB. In contrast, all hydrophilic drugs are facing severe infiltration blockage imposed by the tight cellular junctions of the BBB. Hence, a number of strategies have been devised to improve the efficiency of brain drug delivery and targeted therapy of CNS disorders using multimodal nanosystems (NSs). Conclusions: In order to improve the therapeutic outcomes of CNS drug transfer and targeted delivery, the discriminatory permeability of BBB needs to be taken under control. The carrier-mediated transport machineries of brain capillary endothelial cells (BCECs) can be exploited for the discovery, development and delivery of small molecules into the brain. Further, the receptor-mediated transport systems can be recruited for the delivery of macromolecular biologics and multimodal NSs into the brain.
147 citations
TL;DR: A comprehensive review on the current status of using targeted SPIONs in tumor detection and also the potential hurdles to overcome is performed.
TL;DR: The ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections.
Abstract: Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms.
TL;DR: In this paper, a brief review of recent publications on the positive advantages of blending vegetable oils with different properties to obtain new oil mixtures is presented, and results show that oil blending is widely used in food industry to produce blended oils with improved stability and nutritional characteristics at an affordable price.
Abstract: Background Oils and fats have many functions in food product preparation. Quality, stability and nutritional features of oils are the most important factors in food technology. There is no pure oil with good functional and nutritional properties and appropriate oxidative stability. Therefore, vegetable oils are modified using different methods to enhance their commercial applications and to improve their nutritional quality. Modification methods are hydrogenation, interesterification, fractionation and blending. Scope and approach Trans isomers of fatty acids formed during hydrogenation are known to have negative effects on health. Interesterification needs special equipment and is more expensive. Fractionation is also applicable only for some fats/oils. Blending should not have any adverse effects on health attributes. Blending vegetable fats/oils with different compositions and properties is one of the simplest methods to create new specific products with desired textural, oxidative and nutritional properties which lead to improved industrial applications. Key findings and conclusions This paper is a brief review of recent publications on the positive advantages of blending vegetable oils with different properties to obtain new oil mixtures. There are many researches on oil blending, and results show that oil blending is widely used in food industry to produce blended oils with improved stability and nutritional characteristics at an affordable price. In the future, there are also many economical and health reasons for the production of new oil blends using new and conventional oil sources to be introduced to the market.
TL;DR: The current study tried to establish a simple and fast method for the preparation of BSA and HSA nanoparticles, based on an improved desolvation procedure under the aspect of a controllable particle size around 100nm for drug delivery applications.
TL;DR: A novel antibiotic-eluting nanocomposite hydrogel was designed via incorporation of mesoporous silica MCM-41 as a nano drug carrier into carboxymethylcellulose hydrogels that exhibited an enhanced in vitro swelling, erosion, water vapor and oxygen permeability, and antimicrobial activity.
TL;DR: In this paper, the results of numerical analyses performed by Dali et al. on their experimental solubility of gallic acid in aqueous mixtures of acetonitrile, 1-propanol and 2-pro panol at different temperatures, in terms of the data modeling according to the Jouyban-Acree model and also the evaluation of the preferential solvation of this compound by organic solvents and water in the saturated mixtures based on the inverse Kirkwood-Buff integrals.
TL;DR: A review of particle size and size distribution comparisons of solid lipid nanoparticles and nanostructured lipid carriers in comparable states highlights the influence of preparation conditions and type of lipidic components on the size of SLN and NLC in comparableStates.
Abstract: During the past decade, pharmaceutical science has seen rapid growth in interest for nanoscale materials. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are popular research topics recently introduced as nano-scale drug carriers; they have shown numerous merits in drug delivery. Size is the most important index in a nanocarrier affecting its drug delivery efficiency. The influence of preparation conditions and type of lipidic components on the size of SLN and NLC in comparable states seems to be interesting for researchers who investigate these types of carriers. This review highlights the results of SLN and NLC particle size and size distribution comparisons.
TL;DR: MUC1-aptamer targeted Au@SPIONs could serve as promising theranostic agents for simultaneous MR imaging and photothermal therapy of cancer cells and they could be exploited as contrast agents.
TL;DR: The potential roles of microRNAs as potential biomarkers for CRC diagnosis, and treatment are summarized.
TL;DR: Molecular mechanisms and tumor microenvironment leading to decreased drug sensitivity, and strategies of reversing drug resistance are described.
TL;DR: The present review discusses about some of the most successful drugs in RA therapy and their side effects and also focuses on key design parameters of RA-targeted nanotechnology-based strategies for improving RA therapies.
TL;DR: Ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.
TL;DR: The present paper aims to introduce MSC-DEs as a novel hope in cell-free therapy after testing their functions in various disease models and revealed that their functions are similar to those of MSCs.
Abstract: Mesenchymal stromal/stem cells (MSCs) are involved in tissue homeostasis through direct cell-to-cell interaction, as well as secretion of soluble factors. Exosomes are the sort of soluble biological mediators that obtained from MSCs cultured media in vitro. MSC-derived exosomes (MSC-DEs) which produced under physiological or pathological conditions are central mediators of intercellular communications by conveying proteins, lipids, mRNAs, siRNA, ribosomal RNAs and miRNAs to the neighbor or distant cells. MSC-DEs have been tested in various disease models, and the results have revealed that their functions are similar to those of MSCs. They have the supportive functions in organisms such as repairing tissue damages, suppressing inflammatory responses, and modulating the immune system. MSC-DEs are of great interest in the scope of regenerative medicine because of their unique capacity to the regeneration of the damaged tissues, and the present paper aims to introduce MSC-DEs as a novel hope in cell-free therapy.
TL;DR: The present review intends to provide the reader an overview of the current state of the graphene based biomaterials in bone tissue engineering, its limitations and hopes as well as the future research trends for this exciting field of science.
Abstract: Tissue engineering and regenerative medicine represent areas of increasing interest because of the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Graphene and its derivatives have attracted much interest for applications in bone tissue engineering. For this purpose, this review focuses on more recent advances in tissue engineering based on graphene-biomaterials from 2013 to May 2015. The purpose of this article was to give a general description of studies of nanostructured graphene derivatives for bone tissue engineering. In this review, we highlight how graphene family nanomaterials are being exploited for bone tissue engineering. Firstly, the main requirements for bone tissue engineering were discussed. Then, the mechanism by which graphene based materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. In addition, graphene-based bioactive glass, as a potential drug/growth factor carrier, was reviewed which includes the composition-structure-drug delivery relationship and the functional effect on the tissue-stimulation properties. Also, the effect of structural and textural properties of graphene based materials on development of new biomaterials for production of bone implants and bone cements were discussed. Finally, the present review intends to provide the reader an overview of the current state of the graphene based biomaterials in bone tissue engineering, its limitations and hopes as well as the future research trends for this exciting field of science.
TL;DR: The goal of the present article is to review the current state of nanoparticles used for antimicrobial purposes in root canal infections to understand their shortcomings and their probable cellular effects and toxicity as well as environmental effects.
TL;DR: The structure, biogenesis, and mode of action of lncRNAs are reviewed and the involvement of lNCRNAs in drug resistance will be discussed in detail.
TL;DR: It is proposed that responses of cancer cells to drugs are not exclusively determined by their intrinsic characteristics but are also controlled by deriving signals from tumor microenvironment, which modifies responses to chemotherapy in breast cancer.
TL;DR: It is confirmed that curcumin-loaded PLGA-PEG has more cytotoxic effects on the MCF-7 breast cancer cell line and could be exploited as a potential source for developing novel drugs against breast cancer.
Abstract: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women worldwide. Herbal medicines have tremendous potential as promising agents for the treatment of cancer. Curcumin is a natural polyphenol which has many anticancer effects. Because of its low aqueous solubility, low bioavailability, and quick degradation and metabolism, curcumin was released using PLGA-PEG nanoparticles. Herein, the efficiency of pure curcumin and curcumin-loaded PLGA-PEG in MCF-7 human breast cancer cell lines was studied. (1)H NMR, FT-IR and SEM demonstrated PLGA-PEG structure and curcumin loaded on nanoparticles. Subsequently, the cytotoxic effects of free curcumin and curcumin-loaded PLGA-PEG were determined via an MTT assay. Our study confirmed that curcumin-loaded PLGA-PEG has more cytotoxic effects on the MCF-7 breast cancer cell line and could be exploited as a potential source for developing novel drugs against breast cancer.
TL;DR: The food application of liposomes and nanoliposomes as emerging carrier vehicles of vitamins, enzymes, food antimicrobials, essential oils, and polyphenols is discussed in detail.
Abstract: Liposomes are attractive encapsulation systems that provide enhanced stability of encapsulated materials against a range of environmental, enzymatic, and chemical stresses, including the presence of enzymes or reactive chemicals, and exposure to extreme pH, temperature, and ionic strength changes. Liposomes have been widely used in the pharmaceutical and food industries because of their biocompatibility, biodegradability, absence of toxicity, small size, and ability to carry a wide variety of bioactive compounds due to the amphiphilicity of the phospholipid encapsulating material. In the food industry, liposomes have recently been used to deliver different functional compounds in food systems. In this paper, the food application of liposomes and nanoliposomes as emerging carrier vehicles of vitamins, enzymes, food antimicrobials, essential oils, and polyphenols is discussed in detail.
TL;DR: The antimicrobial property of silver is associated to the quantity of silver and the grade of silver released, as it binds to tissue proteins and gets operational alterations in the bacterial cell wall and nuclear membrane leading to cell modification and death.
Abstract: The antimicrobial property of silver is associated to the quantity of silver and the grade of silver released. The ionized silver is extremely sensitive, as it binds to tissue proteins and gets operational alterations in the bacterial cell wall and nuclear membrane leading to cell modification and death.Silver nanoparticles have the talent to anchor to the bacterial cell wall and consequently infiltrate it, so causing physical modifications in the cell membrane like the absorptivity of the cell membrane and death of the cell. There are numerous concepts on the act of silver nanoparticle on bacteria to reason the microbicidal influence.