Institution
Tabriz University of Medical Sciences
Education•Tabriz, Iran•
About: Tabriz University of Medical Sciences is a education organization based out in Tabriz, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 11499 authors who have published 17525 publications receiving 241099 citations.
Topics: Population, Cancer, Medicine, Solubility, Randomized controlled trial
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a review of dendrimer-based targeted delivery of drugs/genes and co-delivery systems mainly for cancer therapy is presented, where the authors discuss dendriplexes that can preserve the nucleic acids from degradation.
250 citations
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TL;DR: The promotion of cancer immunotherapy targeting PD‐1 immunoinhibitory pathway is discussed and attempts to identify novel and well‐suited predictive biomarkers are sensed.
Abstract: Over the course of past few years, cancer immunotherapy has been accompanied with promising results. However, preliminary investigations with respect to immunotherapy concentrated mostly on targeting the immune checkpoints, nowadays, emerge as the most efficient strategy to raise beneficial antitumor immune responses. Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells. PD-1 is considered as an immune checkpoint and protects against autoimmune responses through both induction of apoptosis in antigen-specific T cells and inhibiting apoptosis in regulatory T cells. Several clinical trials exerting PD-1 monoclonal antibodies as well as other immune-checkpoint blockades have had prosperous outcomes and opened new horizons in tumor immunotherapy. Nonetheless, a bulk of patients have failed to respond to these newly emerging immune-based approach and the survival rate was not satisfying. Additional strategies, especially combination therapies, has been initiated and been further promising. Attempts to identify novel and well-suited predictive biomarkers are also sensed. In this review, the promotion of cancer immunotherapy targeting PD-1 immunoinhibitory pathway is discussed.
246 citations
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TL;DR: The state-of-the-art preclinical and clinical evidence regarding the efficacy of brain PBM therapy is reviewed, with a focus on the transcranial PBM approach.
Abstract: Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and gene expression. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as well as neurogenesis and synaptogenesis. Its therapeutic role in disorders such as dementia and Parkinson’s disease, as well as to treat stroke, brain trauma, and depression has gained increasing interest. In the transcranial PBM approach, delivering a sufficient dose to achieve optimal stimulation is challenging due to exponential attenuation of light penetration in tissue. Alternative approaches such as intracranial and intranasal light delivery methods have been suggested to overcome this limitation. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of brain PBM therapy.
246 citations
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TL;DR: The antibacterial activity of as-prepared ZnONPs was investigated against several bacteria such as Listeria monocytogenes, Escherichia coli, Salmonella typhimurium and more.
241 citations
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TL;DR: In this paper, the effects of probiotic supplementation on disease activity and inflammatory cytokines in patients with RA were assessed by a rheumatologist at baseline and at the end of the trial.
240 citations
Authors
Showing all 11569 results
Name | H-index | Papers | Citations |
---|---|---|---|
Theo Vos | 156 | 502 | 186409 |
Derrick A Bennett | 90 | 233 | 120764 |
Mohammad Abdollahi | 90 | 1045 | 35531 |
Albert Gjedde | 85 | 548 | 28653 |
Nassim Kamar | 73 | 628 | 20442 |
Nima Rezaei | 72 | 1215 | 26295 |
Alireza Khataee | 68 | 525 | 20805 |
William E. Acree | 66 | 958 | 21196 |
Mohammad Athar | 63 | 329 | 14384 |
Amir H. Mohammadi | 62 | 698 | 16044 |
Ali Montazeri | 61 | 625 | 17494 |
Ali Nokhodchi | 55 | 322 | 9087 |
Muhammad Naveed | 54 | 346 | 10376 |
Behrooz Z. Alizadeh | 52 | 189 | 13793 |
Mohammad Reza Zali | 51 | 804 | 12541 |