Institution
Tabriz University of Medical Sciences
Education•Tabriz, Iran•
About: Tabriz University of Medical Sciences is a education organization based out in Tabriz, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 11499 authors who have published 17525 publications receiving 241099 citations.
Topics: Population, Cancer, Medicine, Solubility, Randomized controlled trial
Papers published on a yearly basis
Papers
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TL;DR: Considering the high prevalence of postpartum diabetes and its related factors in Iran, strategic planning for disease prevention and reduction is inevitable.
Abstract: Background: Gestational Diabetes (GD) is one of the major public health issues. The purpose of the present study was to perform a systematic review and meta-analysis to assess the risk factors and prevalence rate of this disorder in Iran. Methods: This systematic review and meta- analysis article was prepared using the databases of Science Direct, PubMed, Scopus, Magiran, Iranmedex and SID, Google search engine, Gray Literature, reference lists check and hand searching using keywords such as "prevalence", "gestational diabetes mellitus", "GDM", "risk factor*", "Iran" and "Postpartum Diabetes". The selected papers were fully reviewed and the required information for the systematic review was extracted and summarized using extraction table in Microsoft Office Excel software. Results: Twenty-four of 1011 papers were quite relevant to the objectives of the review so they were included. The mean age of the participants was 29.43±4.97 yr and the prevalence of GDMwas 3.41% (the highest and the lowest prevalence rates were 18.6% and 1.3% respectively). Among the influential factors mentioned in the literature, potential causes of GDM are gestational age, history of gestational diabetes, family history of diabetes, body mass index, abortions and parity, and history of macrosomia. Conclusion: Considering the high prevalence of postpartum diabetes and its related factors in Iran, strategic planning for disease prevention and reduction is inevitable.
99 citations
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TL;DR: In this paper, the expression levels of miR-142-3p and Bach-1 mRNA were measured using quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and IHC.
Abstract: Background: Breast cancer is the most common type of cancer among women, and despite improved treatments, it remains a major challenge. However, improved mechanistic insight may lead to novel therapeutic strategies. miR-142-3p belongs to the miR-142 family and is involved in pathogenesis and metastasis of various types of malignancies by targeting several important messenger RNAs (mRNAs) including Bach-1. This is especially true for breast cancer, where Bach-1 is involved in the metastatic spread by deregulation of metastasis-associated genes. Methods: In this study, we collected 24 breast cancer tissues with 24 adjusted normal tissues to measure the expression levels of miR-142-3p and Bach-1 mRNA using quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and IHC. miR-142-3p targeting of Bach-1 expression in MCF-7 and MDA-MB-468 breast cancer cells was evaluated using bioinformatics, qRT-PCR and western blot analyses. The cellular proliferation, invasion, and migration were assessed by MTT, transwell matrigel and wound healing assay and the EMT-associated proteins C-X-C chemokine receptor type 4 (CXCR-4), matrix metalloproteinase-9 (MMP9), and vascular endothelial growth factor receptor (VEGFR) were analyzed by western blot analysis. Also, the expression levels of tumor suppressors including miR-330, miR-145, and miR-34a were estimated by qRT-PCR. Results: Analysis of paired specimens of primary malignant and normal tissues showed that miR-142-3p was downregulated, while Bach-1 mRNA and protein both were overexpressed in the breast cancer tumors. This inverse relationship was confirmed by cell line experiments demonstrating that miR-142-3p expression reduced Bach-1 mRNA levels. Furthermore, replacement of miR-142-3p could inhibit the proliferation, invasion, and migration in breast cancer potentially by targeting of Bach-1 mRNA and subsequent inhibition of CXCR4, MMP9, and VEGFR protein expressions. In addition, induction of miR-142-3p could upregulate tumor suppressor miRNAs, including miR-330, miR-145, and miR34a. Conclusion: For the first time, our results revealed that miR-142-3p could target Bach-1in breast cancer cells leading to the reduction of EMT-related proteins and reduced cell proliferation, invasion, and migration. The results also demonstrated that miR-142-3p could regulate important tumor suppressor miRNAs in breast cancer cells. In conclusion, our results suggest that miR-142-3p could be a good candidate for the targeted therapy of breast cancer, especially for the invasive type.
99 citations
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TL;DR: Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017, and future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
Abstract: Background Past research in population health trends has shown
that injuries form a substantial burden of population health loss.
Regular updates to injury burden assessments are critical. We report
Global Burden of Disease (GBD) 2017 Study estimates on morbidity
and mortality for all injuries.
Methods We reviewed results for injuries from the GBD 2017 study.
GBD 2017 measured injury-specific mortality and years of life lost
(YLLs) using the Cause of Death Ensemble model. To measure non-fatal
injuries, GBD 2017 modelled injury-specific incidence and converted
this to prevalence and years lived with disability (YLDs). YLLs and YLDs
were summed to calculate disability-adjusted life years (DALYs).
Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138)
injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554)
deaths in 2017, while age-standardised mortality decreased from 1079
(1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were
354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802)
new cases of injury globally, which increased to 520 710 288 (493
430 247 to 547 988 635) new cases in 2017. During this time, agestandardised incidence decreased non-significantly from 6824 (6534 to
7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017,
age-standardised DALYs decreased from 4947 (4655 to 5233) per
100 000 to 3267 (3058 to 3505).
Interpretation Injuries are an important cause of health loss
globally, though mortality has declined between 1990 and 2017.
Future research in injury burden should focus on prevention in highburden populations, improving data collection and ensuring access to
medical care.
99 citations
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TL;DR: The antimicrobial property of silver is associated to the quantity of silver and the grade of silver released, as it binds to tissue proteins and gets operational alterations in the bacterial cell wall and nuclear membrane leading to cell modification and death.
Abstract: The antimicrobial property of silver is associated to the quantity of silver and the grade of silver released. The ionized silver is extremely sensitive, as it binds to tissue proteins and gets operational alterations in the bacterial cell wall and nuclear membrane leading to cell modification and death.Silver nanoparticles have the talent to anchor to the bacterial cell wall and consequently infiltrate it, so causing physical modifications in the cell membrane like the absorptivity of the cell membrane and death of the cell. There are numerous concepts on the act of silver nanoparticle on bacteria to reason the microbicidal influence.
99 citations
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TL;DR: Preparing nanocomposite scaffolds with biocompatibility with high antimicrobial effects, good mechanical properties, and high porosity are revealed and could be use in further in-vivo uses of wound dressing.
99 citations
Authors
Showing all 11569 results
Name | H-index | Papers | Citations |
---|---|---|---|
Theo Vos | 156 | 502 | 186409 |
Derrick A Bennett | 90 | 233 | 120764 |
Mohammad Abdollahi | 90 | 1045 | 35531 |
Albert Gjedde | 85 | 548 | 28653 |
Nassim Kamar | 73 | 628 | 20442 |
Nima Rezaei | 72 | 1215 | 26295 |
Alireza Khataee | 68 | 525 | 20805 |
William E. Acree | 66 | 958 | 21196 |
Mohammad Athar | 63 | 329 | 14384 |
Amir H. Mohammadi | 62 | 698 | 16044 |
Ali Montazeri | 61 | 625 | 17494 |
Ali Nokhodchi | 55 | 322 | 9087 |
Muhammad Naveed | 54 | 346 | 10376 |
Behrooz Z. Alizadeh | 52 | 189 | 13793 |
Mohammad Reza Zali | 51 | 804 | 12541 |