Institution
Universidad del Desarrollo
Education•Santiago, Chile•
About: Universidad del Desarrollo is a education organization based out in Santiago, Chile. It is known for research contribution in the topics: Population & Entrepreneurship. The organization has 2695 authors who have published 3578 publications receiving 52302 citations.
Topics: Population, Entrepreneurship, Stroke, Medicine, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the prevalence of evidence of residual obstetric anal sphincter injury, to evaluate its association with anal incontinence (AI) and to establish minimal diagnostic criteria for significant (residual) external anal spithincter (EAS) trauma.
Abstract: Objectives
To determine the prevalence of evidence of residual obstetric anal sphincter injury, to evaluate its association with anal incontinence (AI) and to establish minimal diagnostic criteria for significant (residual) external anal sphincter (EAS) trauma.
Methods
This was a retrospective analysis of ultrasound volume datasets of 501 patients attending a tertiary urogynecological unit. All patients underwent a standardized interview including determination of St Mark's score for those presenting with AI. Tomographic ultrasound imaging (TUI) was used to evaluate the EAS and the internal anal sphincter (IAS).
Results
Among a total of 501 women, significant EAS and IAS defects were found in 88 and 59, respectively, and AI was reported by 69 (14%). Optimal prediction of AI was achieved using a model that included four abnormal slices of the EAS on TUI. IAS defects were found to be less likely to be associated with AI. In a multivariable model controlling for age and IAS trauma, the presence of at least four abnormal slices gave an 18-fold (95% CI, 9–36; P < 0.0001) increase in the likelihood of AI, compared with those with fewer than four abnormal slices. Using receiver–operating characteristics curve statistics, this model yielded an area under the curve of 0.86 (95% CI, 0.80–0.92).
Conclusions
Both AI and significant EAS trauma are common in patients attending urogynecological units, and are strongly associated with each other. Abnormalities of the IAS seem to be less important in predicting AI. Our data support the practice of using, as a minimal criterion, defects present in four of the six slices on TUI for the diagnosis of significant EAS trauma. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
59 citations
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TL;DR: In this paper, the effect of adding reclaimed asphalt pavement (RAP) and metallic fibers was studied, and it was concluded that asphalt mixtures with RAP and metal fibers have the potential for crack-healing via microwave heating.
59 citations
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Clinical Trial Service Unit1, University of Cambridge2, Auckland University of Technology3, University of Auckland4, Danube University Krems5, University College London6, Queen Mary University of London7, University of Calgary8, University of Washington9, Universidad del Desarrollo10, University of Chile11, University of Bari12, University of Ulm13, University of Limoges14, University of Oxford15, University of Alberta16
TL;DR: The introduction and use of the STROND checklist should lead to more consistent, transparent and contextualised reporting of descriptive neuroepidemiological studies resulting in more applicable and comparable findings and ultimately support better healthcare decisions.
Abstract: Incidence and prevalence studies of neurological disorders play an important role in assessing the burden of disease and planning services. However, the assessment of disease estimates is hindered by problems in reporting for such studies. Despite a growth in published reports, existing guidelines relate to analytical rather than descriptive epidemiological studies. There are also no user-friendly tools (e.g., checklists) available for authors, editors and peer-reviewers to facilitate best practice in reporting of descriptive epidemiological studies for most neurological disorders. The Standards of Reporting of Neurological Disorders (STROND) is a guideline that consists of recommendations and a checklist to facilitate better reporting of published incidence and prevalence studies of neurological disorders. A review of previously developed guidance was used to produce a list of items required for incidence and prevalence studies in neurology. A three-round Delphi technique was used to identify the 'basic minimum items' important for reporting, as well as some additional 'ideal reporting items'. An e-consultation process was then used in order to gauge opinion by external neuroepidemiological experts on the appropriateness of the items included in the checklist. Of 38 candidate items, 15 items and accompanying recommendations were developed along with a user-friendly checklist. The introduction and use of the STROND checklist should lead to more consistent, transparent and contextualised reporting of descriptive neuroepidemiological studies resulting in more applicable and comparable findings and ultimately support better healthcare decisions.
58 citations
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TL;DR: Suptavumab did not reduce overall RSV hospitalizations or outpatient LRTI because of a newly circulating mutant strain of RSV B and genetic variation in circulating RSV strains will continue to challenge prevention efforts.
Abstract: Background Respiratory syncytial virus (RSV) is a major cause of childhood medically attended respiratory infection (MARI). Methods We conducted a randomized, double-blind, placebo-controlled phase 3 trial in 1154 preterm infants of 1 or 2 doses of suptavumab, a human monoclonal antibody that can bind and block a conserved epitope on RSV A and B subtypes, for the prevention of RSV MARI. The primary endpoint was proportion of subjects with RSV-confirmed hospitalizations or outpatient lower respiratory tract infection (LRTI). Results There were no significant differences between primary endpoint rates (8.1%, placebo; 7.7%, 1-dose; 9.3%, 2-dose). Suptavumab prevented RSV A infections (relative risks, .38; 95% confidence interval [CI], .14-1.05 in the 1-dose group and .39 [95% CI, .14-1.07] in the 2-dose group; nominal significance of combined suptavumab group vs placebo; P = .0499), while increasing the rate of RSV B infections (relative risk 1.36 [95% CI, .73-2.56] in the 1-dose group and 1.69 [95% CI, .92-3.08] in the 2-dose group; nominal significance of combined suptavumab group vs placebo; P = .12). Sequenced RSV isolates demonstrated no suptavumab epitope changes in RSV A isolates, while all RSV B isolates had 2-amino acid substitution in the suptavumab epitope that led to loss of neutralization activity. Treatment emergent adverse events were balanced across treatment groups. Conclusions Suptavumab did not reduce overall RSV hospitalizations or outpatient LRTI because of a newly circulating mutant strain of RSV B. Genetic variation in circulating RSV strains will continue to challenge prevention efforts. Clinical trials registration NCT02325791. https://clinicaltrials.gov/ct2/show/NCT02325791.
58 citations
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TL;DR: Using time-kill assays, evidence is provided for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
Abstract: The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
58 citations
Authors
Showing all 2724 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joseph P. Broderick | 130 | 504 | 72779 |
Craig S. Anderson | 101 | 650 | 49331 |
Pierre Amarenco | 97 | 415 | 35259 |
Cynthia S. Crowson | 88 | 452 | 29703 |
Heinrich Mattle | 84 | 405 | 27581 |
Jaana Suvisaari | 71 | 424 | 31878 |
Charles S. Rabkin | 59 | 173 | 16858 |
Catterina Ferreccio | 58 | 189 | 21407 |
Julien Labreuche | 52 | 176 | 10553 |
José Mario Martínez | 51 | 263 | 14041 |
Kurt A. Schalper | 49 | 148 | 8836 |
Cesar A. Arias | 48 | 247 | 9344 |
Pablo M. Lavados | 38 | 135 | 20707 |
Carlo Giupponi | 37 | 217 | 4621 |
Carlos Eyzaguirre | 35 | 123 | 4625 |