Institution
Universidad del Desarrollo
Education•Santiago, Chile•
About: Universidad del Desarrollo is a education organization based out in Santiago, Chile. It is known for research contribution in the topics: Population & Entrepreneurship. The organization has 2695 authors who have published 3578 publications receiving 52302 citations.
Topics: Population, Entrepreneurship, Stroke, Medicine, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Results suggest that at near-term age, thalamus WM microstructure may be particularly vulnerable to certain neonatal risk factors and Interactions between albumin, bilirubin, phototherapy, and brain development warrant further investigation.
50 citations
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TL;DR: Key cases with the most notable clinical, dermatoscopic, and histopathologic features are presented, highlighting the practical issues of making an accurate diagnosis and choosing the best therapy.
Abstract: This review presents the main challenges encountered when diagnosing unusual variants of malignant melanoma with the aim of raising awareness to allow application of the most appropriate treatment strategies. Although these melanomas are often rare, their misdiagnosis potentially jeopardizes patients’ health and survival, and has medicolegal implications. The clinical and histologic presentations of melanoma vary greatly, and assessment of uncommon melanomas can be difficult for practitioners because of their scarcity and resemblance to other dermatologic entities. The most problematic melanoma types are desmoplastic melanoma, polypoid melanoma, primary dermal melanoma, verrucous malignant melanoma, pigmented epithelioid melanocytoma, mucosal melanoma, follicular melanoma and melanoma with non-melanocytic differentiation. The two most difficult-to-diagnose subtypes of melanoma are the nevoid and the amelanotic melanomas. Some specific attributes of these variants can be more easily recognized with digital dermatoscopy, facilitating early detection and possibly avoiding invasive procedures. Key cases with the most notable clinical, dermatoscopic, and histopathologic features are presented, highlighting the practical issues of making an accurate diagnosis and choosing the best therapy.
50 citations
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15 May 2018-Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
TL;DR: CPAP treatment of OSA in PD is associated with improved overall non-motor symptoms, sleep quality, anxiety, and global cognitive function over a 12-month period.
Abstract: Study Objectives:Parkinson disease (PD) non-motor symptoms are associated with sleep disorders and impair quality of life. Our objective was to assess the effect of obstructive sleep apnea (OSA) tr...
50 citations
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TL;DR: In these fetal treatment centers, the balloon could always be removed successfully, with the use of fetoscopy preferred over ultrasound‐guided puncture and the development of a stylet to puncture the balloon, leading to shorter operating time and easier reestablishment of airways.
50 citations
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University of California, Los Angeles1, Illinois Institute of Technology2, University of Southern California3, Oregon Health & Science University4, Duke University5, University of Pittsburgh6, Syracuse University7, State University of New York System8, Newcastle University9, University of California, Davis10, King's College London11, University Health Network12, Utrecht University13, University of Toronto14, Children's Hospital of Philadelphia15, University of Pennsylvania16, University of California, Santa Barbara17, Utah System of Higher Education18, University of British Columbia19, Cardiff University20, Pontifical Catholic University of Chile21, Universidad del Desarrollo22
TL;DR: In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness.
Abstract: Objective:
22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group.
Methods:
Subcortical structures were measured using harmonized protocols for gross volume and subcortical shape morphometry in 533 individuals with 22q11DS and 330 matched healthy control subjects (age range, 6–56 years; 49% female).
Results:
Compared with the control group, the 22q11DS group showed lower intracranial volume (ICV) and thalamus, putamen, hippocampus, and amygdala volumes and greater lateral ventricle, caudate, and accumbens volumes (Cohen’s d values, −0.90 to 0.93). Shape analysis revealed complex differences in the 22q11DS group across all structures. The larger A-D deletion was associated with more extensive shape alterations compared with the smaller A-B deletion. Participants with 22q11DS with psychosis showed lower ICV and hippocampus, amygdala, and thalamus volumes (Cohen’s d values, −0.91 to 0.53) compared with participants with 22q11DS without psychosis. Shape analysis revealed lower thickness and surface area across subregions of these structures. Compared with subcortical findings from other neuropsychiatric disorders studied by the ENIGMA consortium, significant convergence was observed between participants with 22q11DS with psychosis and participants with schizophrenia, bipolar disorder, major depressive disorder, and obsessive-compulsive disorder.
Conclusions:
In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness. Findings indicate significant overlap between 22q11DS-associated psychosis, idiopathic schizophrenia, and other severe neuropsychiatric illnesses.
50 citations
Authors
Showing all 2724 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joseph P. Broderick | 130 | 504 | 72779 |
Craig S. Anderson | 101 | 650 | 49331 |
Pierre Amarenco | 97 | 415 | 35259 |
Cynthia S. Crowson | 88 | 452 | 29703 |
Heinrich Mattle | 84 | 405 | 27581 |
Jaana Suvisaari | 71 | 424 | 31878 |
Charles S. Rabkin | 59 | 173 | 16858 |
Catterina Ferreccio | 58 | 189 | 21407 |
Julien Labreuche | 52 | 176 | 10553 |
José Mario Martínez | 51 | 263 | 14041 |
Kurt A. Schalper | 49 | 148 | 8836 |
Cesar A. Arias | 48 | 247 | 9344 |
Pablo M. Lavados | 38 | 135 | 20707 |
Carlo Giupponi | 37 | 217 | 4621 |
Carlos Eyzaguirre | 35 | 123 | 4625 |