University of Leicester

About: University of Leicester is a education organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 26469 authors who have published 61444 publications receiving 2305724 citations. The organization is also known as: Leicester University.

Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials.

Abstract: Objective To review the clinical effectiveness of oseltamivir and zanamivir for the treatment and prevention of influenza A and B. Design Systematic review and meta-analyses of randomised controlled trials. Data sources Published studies were retrieved from electronic bibliographic databases; supplementary data were obtained from the manufacturers. Selection of studies Randomised controlled, double blind trials that were published in English, had data available before 31 December 2001, evaluated treatment or prevention of naturally occurring influenza with zanamivir or oseltamivir (if given using the formulation and dosage licensed for clinical use), and reported at least one end point of relevance. Review methods The main outcome measures were the median time to the alleviation of symptoms (for treatment trials) and number of flu episodes avoided (for prevention trials). Three population groups were defined: children aged 12 years and under; otherwise healthy individuals aged 12 to 65 years; and “high risk” individuals (those with certain chronic medical conditions or aged 65 years and older). Results Seventeen treatment trials and seven prevention trials identified met the inclusion criteria. All trials included compared one of the drugs against placebo or standard care. Treatment of children, otherwise healthy individuals, and high risk populations with zanamivir reduced the median duration of symptoms in days respectively by 1.0 (95% confidence interval 0.5 to 1.5), 0.8 (0.3 to 1.3), and 0.9 (-0.1 to 1.9) for the intention to treat population. The corresponding results, in days, for oseltamivir were 0.9 (0.3 to 1.5), 0.9 (0.3 to 1.4), and 0.4 (-0.7 to 1.4). The effect of giving zanamivir and oseltamivir prophylactically resulted in a relative reduction of 70-90% in the odds of developing flu, depending on the strategy adopted and the population studied. Conclusions Evidence from randomised controlled trials consistently supports the view that both oseltamivir and zanamivir are clinically effective for treating and preventing flu. However, evidence is limited for the treatment of certain populations and for all prevention strategies.

XMM-Newton observation of the lockman hole. I. The X-ray data

Abstract: We report on the first deep X-ray survey with the XMM-Newton observatory during the performance verification phase. The field of the Lockman Hole, one of the best studied sky areas over a very wide range of wavelengths, has been observed. A total of ~100 ksec good exposure time has been accumulated. Combining the images of the European Photon Imaging Camera (EPIC) detectors we reach a flux limit of 0.31, 1.4 and , respectively in the 0.5-2, 2-10, and 5-10 keV band. Within an off-axis angle of 10 arcmin we detect 148, 112 and 61 sources, respectively. The log(N )-log(S ) relation in the three bands is compared with previous results. In particular in the 5-10 keV band these observations present the deepest X-ray survey ever, about a factor 20 more sensitive than the previous BeppoSAX observations. Using X-ray spectral diagnostics and the set of previously known, spectroscopically identified ROSAT sources in the field, the new sources can be classified. XMM-Newton detects a significant number (~40% ) of X-ray sources with hard, probably intrinsically absorbed X-ray spectra, confirming a prediction of the population synthesis models for the X-ray background.