Institution
University of Manitoba
Education•Winnipeg, Manitoba, Canada•
About: University of Manitoba is a education organization based out in Winnipeg, Manitoba, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 31888 authors who have published 66592 publications receiving 2095493 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The effect of pH on the K(m) values for ammonia was studied in its oxidation by Nitrosomonas cells and cell-free extracts, suggesting (NH(3)) rather than ( NH(4) (+)) as the actual substrate for oxidation.
Abstract: The effect of pH on the Km values for ammonia was studied in its oxidation by Nitrosomonas cells and cell-free extracts The Km values decreased markedly with increasing pH, suggesting (NH3) rather than (NH4+) as the actual substrate for oxidation
427 citations
TL;DR: Findings from resilience research needs to be applied to determine effective strategies and specific interventions to promote resilience and foster well-being among maltreated children.
Abstract: Objective:Child maltreatment is linked with numerous adverse outcomes that can continue throughout the lifespan. However, variability of impairment has been noted following child maltreatment, maki...
426 citations
TL;DR: In the province of Manitoba, there are limited data on mortality from colorectal cancer (CRC) among patients who have received colonoscopy examinations as mentioned in this paper, but the benefit is not uniform.
426 citations
Washington University in St. Louis1, University of Manitoba2, Alfred I. duPont Hospital for Children3, Monroe Carell Jr. Children's Hospital at Vanderbilt4, University of Arkansas for Medical Sciences5, Boston Children's Hospital6, Belfast Health and Social Care Trust7, St. John's Hospital8, St Vincent Hospital9, Harvard University10, Boston University11, Mayo Clinic12, Discovery Institute13
TL;DR: ENB-0040, an enzyme-replacement therapy, was associated with improved findings on skeletal radiographs and improved pulmonary and physical function in infants and young children with life-threatening hypophosphatasia.
Abstract: Background Hypophosphatasia results from mutations in the gene for the tissue-nonspecific isozyme of alkaline phosphatase (TNSALP). Inorganic pyrophosphate accumulates extracellularly, leading to rickets or osteomalacia. Severely affected babies often die from respiratory insufficiency due to progressive chest deformity or have persistent bone disease. There is no approved medical therapy. ENB-0040 is a bone-targeted, recombinant human TNSALP that prevents the manifestations of hypophosphatasia in Tnsalp knockout mice. Methods We enrolled infants and young children with life-threatening or debilitating perinatal or infantile hypophosphatasia in a multinational, open-label study of treatment with ENB-0040. The primary objective was the healing of rickets, as assessed by means of radiographic scales. Motor and cognitive development, respiratory function, and safety were evaluated, as well as the pharmacokinetics and pharmacodynamics of ENB-0040. Results Of the 11 patients recruited, 10 completed 6 months of...
425 citations
TL;DR: An improved myocardial redox state with vitamin E therapy, coupled with the modulation of the development ofheart failure, may indicate a pathophysiologic role for increased oxidative stress in the pathogenesis of heart failure.
425 citations
Authors
Showing all 32123 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George Davey Smith | 224 | 2540 | 248373 |
| Peer Bork | 206 | 697 | 245427 |
| David A. Weitz | 178 | 1038 | 114182 |
| Yang Yang | 171 | 2644 | 153049 |
| Robert E. W. Hancock | 152 | 775 | 88481 |
| Peter B. Jones | 145 | 1857 | 94641 |
| Peter Lang | 140 | 1136 | 98592 |
| James J. Gross | 139 | 529 | 100206 |
| Steven J.M. Jones | 137 | 594 | 146609 |
| Rajkumar Buyya | 133 | 1066 | 95164 |
| Jeff A. Sloan | 129 | 656 | 65308 |
| Dafna D. Gladman | 129 | 1036 | 75273 |
| Murray B. Stein | 128 | 745 | 89513 |
| Robert W. Heath | 128 | 1049 | 73171 |
| Jürgen Rehm | 126 | 1132 | 116037 |