Institution
University of Manitoba
Education•Winnipeg, Manitoba, Canada•
About: University of Manitoba is a education organization based out in Winnipeg, Manitoba, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 31888 authors who have published 66592 publications receiving 2095493 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that early protocol biopsies and the treatment of subclinical rejection with corticosteroids may lead to better histologic and functional outcomes in renal transplant recipients.
Abstract: The prevalence of subclinical rejection, by the Banff criteria, is approximately 30% in the first 3 mo in renal transplant recipients. A randomized study was performed to determine whether the treatment of subclinical rejection with corticosteroids was associated with improved outcomes in these patients. Seventy-two patients, stratified by donor source, were randomized to biopsies at 1, 2, 3, 6, and 12 mo (Biopsy group), or to 6- and 12-mo biopsies only (Control group). Patients were analyzed by "intent to treat" and were followed for a minimum of 2 yr. Patients in the Biopsy arm of the study had a significant decrease in early (months 2 and 3) and late (months 7 to 12) acute rejection episodes, a reduced chronic tubulointerstitial score at 6 mo, and a lower serum creatinine at 24 mo than did patients in the Control arm. There was a trend toward an increase in infectious morbidity, but no increase in mortality, in the patients randomized to the Biopsy group. The results of this study suggest that early protocol biopsies and the treatment of subclinical rejection with corticosteroids may lead to better histologic and functional outcomes in renal transplant recipients.
461 citations
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457 citations
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TL;DR: The risk of subsequent graft failure is significantly worse in the presence of C4d+ staining and circulating donor-specific antibody in subsequent LGF, and groups C and D (C4d+) were at significantly greater risk for LGF than groups A and B.
Abstract: Background Late graft failure (LGF) is believed to be the consequence of immunologic and nonimmunologic insults leading to progressive deterioration in kidney function. We studied recipients with new onset late kidney graft dysfunction (n=173) to determine the importance of C4d staining and circulating donor-specific antibody (DSA) in subsequent LGF. Methods One hundred seventy-three subjects transplanted before October 1, 2005 (mean time after transplant 7.3+/-6.0 years) had a baseline serum creatinine level of 1.4+/-0.3 mg/dL before January 1, 2006 and underwent biopsy for new onset graft dysfunction after that date (mean creatinine at biopsy 2.7+/-1.6 mg/dL). Statistical analysis was based on central DSA and blinded pathology determinations. Results Subjects were divided into four groups based on C4d and DSA: no C4d, no DSA (group A; n=74); only DSA (group B; n=31); only C4d (group C; n=28); and both C4d and DSA (group D; n=40). Among DSA+ recipients (groups B and D), group D had broader reactivity and a stronger DSA response. After 2 years, groups C and D (C4d+) were at significantly greater risk for LGF than groups A and B. Adjusting for inflammation (Banff i, t, g, and ptc scores) did not change the outcome. Local diagnosis of calcineurin inhibitor nephrotoxicity was spread across all four subgroups and did not impact risk of LGF. Conclusions Evidence of antibody-mediated injury (DSA or C4d) is common (57%) in patients with new onset late kidney allograft dysfunction. The risk of subsequent graft failure is significantly worse in the presence of C4d+ staining.
456 citations
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TL;DR: The impact of maternal intrapartum antibiotic prophylaxis (IAP) on infant gut microbiota, and to explore whether breastfeeding modifies these effects, are determined.
455 citations
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TL;DR: To determine whether enhanced physician contact and an increased frequency of radiography in persons with inflammatory bowel disease influenced the estimated incidence of rib, forearm, and spine fractures, a population-based database was developed by using Manitoba Health administrative databases.
Abstract: Patients with inflammatory bowel disease are at increased risk for fracture compared with the general population.
455 citations
Authors
Showing all 32123 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
Peer Bork | 206 | 697 | 245427 |
David A. Weitz | 178 | 1038 | 114182 |
Yang Yang | 171 | 2644 | 153049 |
Robert E. W. Hancock | 152 | 775 | 88481 |
Peter B. Jones | 145 | 1857 | 94641 |
Peter Lang | 140 | 1136 | 98592 |
James J. Gross | 139 | 529 | 100206 |
Steven J.M. Jones | 137 | 594 | 146609 |
Rajkumar Buyya | 133 | 1066 | 95164 |
Jeff A. Sloan | 129 | 656 | 65308 |
Dafna D. Gladman | 129 | 1036 | 75273 |
Murray B. Stein | 128 | 745 | 89513 |
Robert W. Heath | 128 | 1049 | 73171 |
Jürgen Rehm | 126 | 1132 | 116037 |