Institution
University of Sannio
Education•Benevento, Italy•
About: University of Sannio is a education organization based out in Benevento, Italy. It is known for research contribution in the topics: Gravitational wave & LIGO. The organization has 1278 authors who have published 6125 publications receiving 167577 citations. The organization is also known as: Università degli Studi del Sannio & Universita degli Studi del Sannio.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the GEMAS data set is used to set at the European scale the geochemical background reference intervals, at least for regions sharing common lithological settings and a common geological history.
82 citations
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TL;DR: A kinetic analysis showed that for both dyes a pseudo-second order kinetic model adequately describes the available data, and the Langmuir isotherm model in single and binary components has better performance for description of dyes biosorption.
82 citations
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TL;DR: In this article, the problem of optimal energy flow management in multicarrier energy networks in the presence of interconnected energy hubs is addressed by a nonlinear constrained multiobjective optimization problem and solved by a goal attainment based methodology.
81 citations
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TL;DR: It is reported that U HRF1 negatively regulates PPARG and is associated with a higher proliferative, clonogenic and migration potential and the relationship between UHRF1 and PP ARG may have a relevant role in CRC progression, and the results demonstrate that UHRf1 regulatesPPARG silencing and both genes appear to be part of a complex regulatory network.
Abstract: Peroxisome proliferator-activated receptor gamma (PPARG) inactivation has been identified as an important step in colorectal cancer (CRC) progression, although the events involved have been partially clarified. UHRF1 is emerging as a cofactor that coordinates the epigenetic silencing of tumor suppressor genes, but its role in CRC remains elusive. Here, we report that UHRF1 negatively regulates PPARG and is associated with a higher proliferative, clonogenic and migration potential. Consistently, UHRF1 ectopic expression induces PPARG repression through its recruitment on the PPARG promoter fostering DNA methylation and histone repressive modifications. In agreement, UHRF1 knockdown elicits PPARG re-activation, accompanied by positive histone marks and DNA demethylation, corroborating its role in PPARG silencing. UHRF1 overexpression, as well as PPARG-silencing, imparts higher growth rate and phenotypic features resembling those occurring in the epithelial-mesenchymal transition. In our series of 110 sporadic CRCs, high UHRF1-expressing tumors are characterized by an undifferentiated phenotype, higher proliferation rate and poor clinical outcome only in advanced stages III-IV. In addition, the inverse relationship with PPARG found in vitro is detected in vivo and UHRF1 prognostic significance appears closely related to PPARG low expression, as remarkably validated in an independent dataset. The results demonstrate that UHRF1 regulates PPARG silencing and both genes appear to be part of a complex regulatory network. These findings suggest that the relationship between UHRF1 and PPARG may have a relevant role in CRC progression.
81 citations
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TL;DR: The transcriptomic and proteomic profiles of rat ageing skeletal muscle were defined using a combined cDNA array, 2D- and Blue native-PAGE approach to obtain an overview of the interrelated events leading to the transcriptome/proteome/mitoproteome changes likely to underlie the structural/metabolic features of aged skeletal muscle.
81 citations
Authors
Showing all 1300 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alberto Vecchio | 115 | 572 | 79416 |
Andrea Alù | 109 | 1138 | 47717 |
Vijay P. Singh | 106 | 1699 | 55831 |
Kenneth A. Strain | 105 | 485 | 70966 |
N. A. Robertson | 105 | 384 | 69504 |
G. D. Hammond | 100 | 352 | 67549 |
B. Sorazu | 98 | 347 | 65989 |
I. W. Martin | 97 | 352 | 64772 |
Maria Ilaria Del Principe | 93 | 398 | 62000 |
Innocenzo M. Pinto | 89 | 378 | 56567 |
Karl Henrik Johansson | 88 | 1089 | 33751 |
Vincenzo Pierro | 83 | 263 | 42535 |
R. DeSalvo | 83 | 225 | 51227 |
Paolo Addesso | 71 | 202 | 45552 |
Francesco Borrelli | 66 | 327 | 17254 |