University of Sannio

About: University of Sannio is a education organization based out in Benevento, Italy. It is known for research contribution in the topics: Gravitational wave & LIGO. The organization has 1278 authors who have published 6125 publications receiving 167577 citations. The organization is also known as: Università degli Studi del Sannio & Universita degli Studi del Sannio.

Model-driven development of web applications with UWA, MVC and JavaServer faces

Abstract: This paper presents a model-driven approach to the development of web applications based on the Ubiquitous Web Application (UWA) design framework, the Model-View-Controller (MVC) architectural pattern and the JavaServer Faces technology. The approach combines a complete and robust methodology for the user-centered conceptual design of web applications with the MVC metaphor, which improves separation of business logic and data presentation. The proposed approach, by carrying the advantages of Model-Driven Development (MDD) and user-centered design, produces Web applications which are of high quality from the user's point of view and easier to maintain and evolve.

Extracting Change-patterns from CVS Repositories

Abstract: Often, the only sources of information about the evolution of software systems are the systems themselves and their histories. Version control repositories contain information on several thousand of files and on millions of changes. We propose an approach based on dynamic time warping to discover change-patterns, which, for example, describe files that change together almost all the time. We define the synchrony change-pattern to answer the question: given a software system and one file under modification, what others files must be changed? We have applied our approach on PADL, a software system developed in Java, and on Mozilla. Interesting results are achieved even when the discovered groups of co-changing files are compared with these provided by experts

Fiber optic humidity sensors for high-energy physics applications at CERN

Abstract: This work is devoted to a feasibility analysis for the development of novel fiber optic humidity sensors to be applied in high-energy physics (HEP) applications and in particular in experiments actually running at the European Organization for Nuclear Research (CERN). On this line of argument and due to the wide investigations carried out in the last years aimed to assess the radiation hardness capability of fiber optic technology in high energy physics environments, our multidisciplinary research group has been recently engaged in the development of near-field fiber optic sensors based on particle layers of tin dioxide to perform the monitoring of low values of relative humidity RH even at low temperatures. While this sensor type has been successfully employed for ppm and sub-ppm chemical detection in air and water environments, it is the first reported use for relative humidity measurements. The RH sensing performance of fabricated probes was analyzed during a deep experimental campaign carried out in the laboratories of CERN, in Geneve. A very good agreement was observed between humidity measurements provided by the optical fiber sensors and commercial polymer-based hygrometers at 20 °C and 0 °C, with limits of detection for low RH regimes below 0.1%.

NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via Ras/ERK1/2 pathway.

Abstract: To identify the transductional mechanisms responsible for the neuroprotective effect of nitric oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this gaseous mediator on mitochondrial Mn-superoxide dismutase (Mn-SOD) expression and activity. In addition, the possible involvement of Ras/extracellular-regulated kinase (ERK) ERK1/2 pathway in preserving cortical neurons exposed to oxygen and glucose deprivation (OGD) followed by reoxygenation was also examined. Ischemic preconditioning was obtained by exposing neurons to a 30-min sublethal OGD (95% N2 and 5% CO2). Then, after a 24-h interval, neurons were exposed to 3 h of OGD followed by 24 h of reoxygenation (OGD/Rx). Our results revealed that IPC reduced cytochrome c (cyt c) release into the cytosol, improved mitochondrial function, and decreased free radical production. Moreover, it induced an increase in nNOS expression and NO production and promoted ERK1/2 activation. These effects were paralleled by an increase in Mn-SOD expression and activity that persisted throughout the following OGD phase. When the neurons were treated with L-NAME, a well known NOS inhibitor, the increase in Mn-SOD expression occurring during IPC was reduced and, as a result, IPC-induced neuroprotection was prevented. Similarly, when ERK1/2 was inhibited by its selective inhibitor PD98059, the increase in Mn-SOD expression observed during IPC was almost completely abolished. As a result, its neuroprotective effect on cellular survival was thwarted. The present findings indicate that during IPC the increase in Mn-SOD expression and activity are paralleled by NO production. This suggests that NO neuroprotective role occurs through the stimulation of Mn-SOD expression and activity. In particular, NO via Ras activation stimulates downstream ERK1/2 cascade. This pathway, in turn, post-transcriptionally activates Mn-SOD expression and activity, thus promoting neuroprotection during preconditioning.