University of Sannio

About: University of Sannio is a education organization based out in Benevento, Italy. It is known for research contribution in the topics: Gravitational wave & LIGO. The organization has 1278 authors who have published 6125 publications receiving 167577 citations. The organization is also known as: Università degli Studi del Sannio & Universita degli Studi del Sannio.

Modeling clones evolution through time series

Abstract: The actual effort to evolve and maintain a software system is likely to vary depending on the amount of clones (i.e., duplicated or slightly different code fragments) present in the system. This paper presents a method for monitoring and predicting clones evolution across subsequent versions of a software system. Clones are firstly identified using a metric-based approach, then they are modeled in terms of time series identifying a predictive model. The proposed method has been validated with an experimental activity performed on 27 subsequent versions of mSQL, a medium-size software system written in C. The time span period of the analyzed mSQL releases covers four years, from May 1995 (mSQL 1.0.6) to May 1999 (mSQL 2. 0. 10). For any given software release, the identified models was able to predict the clone percentage of the subsequent release with an average error below 4 %. A higher prediction error was observed only in correspondence of major system redesign.

A review on the use of drones for precision agriculture

Abstract: In recent years, there has been a strong activity in the so-called precision agriculture, particularly the monitoring aspect, not only to improve productivity, but also to meet demand of a growing population. At a large scale, precise monitoring of cultivated fields is a quite challenging task. Therefore, this paper aims to propose a survey on techniques, applied to precision agriculture monitoring, through the use of drones equipped with multispectral, thermal and visible cameras. For each application, the main limitations are highlighted and the parameters to be considered before to perform a flight are reported.

Miniaturized Sensing Probes Based on Metallic Dielectric Crystals Self-Assembled on Optical Fiber Tips

Abstract: We propose a novel fabrication process to realize optical sensing probes based on metal–dielectric crystals self-assembled on an optical fiber tip. The breath figure methodology has been adapted to work directly on nonconventional substrates, such as optical fibers, enabling the formation of regular and ordered metallo-dielectric crystals on optical fiber tips. Accurate morphological characterization was carried out to qualify the fabrication process. The reported results indicate that the proposed fabrication technique provides a method for rapid and cost-effective prototyping of photonic–plasmonic nanoprobes for sensing applications. To achieve this goal, we develop a technological platform via the addition of polymer–metal crystals onto the tip of a standard single optical fiber, which is able to support surface plasmon resonances in the near-infrared. A dedicated numerical tool was developed to study and analyze arbitrary subwavelength structures integrated on the optical fiber tip by taking into acco...

Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

Abstract: The relationship between peroxisome proliferator-activated receptor γ (PPARG) expression and epigenetic changes occurring in colorectal-cancer pathogenesis is largely unknown. We investigated whether PPARG is epigenetically regulated in colorectal cancer (CRC) progression. PPARG expression was assessed in CRC tissues and paired normal mucosa by western blot and immunohistochemistry and related to patients' clinicopathological parameters and survival. PPARG promoter methylation was analyzed by methylation-specific-PCR and bisulphite sequencing. PPARG expression and promoter methylation were similarly examined also in CRC derived cell lines. Chromatin immunoprecipitation in basal conditions and after epigenetic treatment was performed along with knocking-down experiments of putative regulatory factors. Gene expression was monitored by immunoblotting and functional assays of cell proliferation and invasiveness. Methylation on a specific region of the promoter is strongly correlated with PPARG lack of expression in 30% of primary CRCs and with patients' poor prognosis. Remarkably, the same methylation pattern is found in PPARG-negative CRC cell lines. Epigenetic treatment with 5′-aza-2′-deoxycytidine can revert this condition and, in combination with trichostatin A, dramatically re-activates gene transcription and receptor activity. Transcriptional silencing is due to the recruitment of MeCP2, HDAC1 and EZH2 that impart repressive chromatin signatures determining an increased cell proliferative and invasive potential, features that can experimentally be reverted. Our findings provide a novel mechanistic insight into epigenetic silencing of PPARG in CRC that may be relevant as a prognostic marker of tumor progression.