Institution
University of Toronto
Education•Toronto, Ontario, Canada•
About: University of Toronto is a education organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 126067 authors who have published 294940 publications receiving 13536856 citations. The organization is also known as: UToronto & U of T.
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TL;DR: It is found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero.
1,831 citations
01 Oct 2015
TL;DR: This is the eighteenth in a series of evaluated sets of rate constants, photochemical cross sections, heterogeneous parameters, and thermochemical parameters compiled by the NASA Panel for Data Evaluation as mentioned in this paper.
Abstract: This is the eighteenth in a series of evaluated sets of rate constants, photochemical cross sections, heterogeneous parameters, and thermochemical parameters compiled by the NASA Panel for Data Evaluation. The data are used primarily to model stratospheric and upper tropospheric processes, with particular emphasis on the ozone layer and its possible perturbation by anthropogenic and natural phenomena. The evaluation is available in electronic form from the following Internet URL: http://jpldataeval.jpl.nasa.gov/
1,830 citations
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TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Abstract: Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
1,829 citations
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TL;DR: The rates of readmission for heart failure and of in-hospital complications did not differ between the two groups, and the survival of patients with heart failure with preserved ejection fraction was similar to that of Patients with reduced ejections fraction.
Abstract: Thirty-one percent of the patients had an ejection fraction of more than 50 percent. Patients with heart failure with preserved ejection fraction were more likely to be older and female and to have a history of hypertension and atrial fibrillation. The presenting history and clinical examination findings were similar for the two groups. The unadjusted mortality rates for patients with an ejection fraction of more than 50 percent were not significantly different from those for patients with an ejection fraction of less than 40 percent at 30 days (5 percent vs. 7 percent, P = 0.08) and at 1 year (22 percent vs. 26 percent, P = 0.07); the adjusted one-year mortality rates were also not significantly different in the two groups (hazard ratio, 1.13; 95 percent confidence interval, 0.94 to 1.36; P = 0.18). The rates of readmission for heart failure and of in-hospital complications did not differ between the two groups. Conclusions Among patients presenting with new-onset heart failure, a substantial proportion had an ejection fraction of more than 50 percent. The survival of patients with heart failure with preserved ejection fraction was similar to that of patients with reduced ejection fraction.
1,827 citations
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TL;DR: In this paper, the authors proposed a solution based on the theory of the excursion sets of F(r, R sub f), the four-dimensional initial density perturbation field smoothed with a continuous hierarchy of filters of radii.
Abstract: It is pointed out that most schemes for determining the mass function of virialized objects from the statistics of the initial density perturbation field suffer from the cloud-in-cloud problem of miscounting the number of low-mass clumps, many of which would have been subsumed into larger objects. The paper proposes a solution based on the theory of the excursion sets of F(r, R sub f), the four-dimensional initial density perturbation field smoothed with a continuous hierarchy of filters of radii R sub f.
1,826 citations
Authors
Showing all 127245 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon H. Guyatt | 231 | 1620 | 228631 |
David J. Hunter | 213 | 1836 | 207050 |
Rakesh K. Jain | 200 | 1467 | 177727 |
Thomas C. Südhof | 191 | 653 | 118007 |
Gordon B. Mills | 187 | 1273 | 186451 |
George Efstathiou | 187 | 637 | 156228 |
John P. A. Ioannidis | 185 | 1311 | 193612 |
Paul M. Thompson | 183 | 2271 | 146736 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Chris Sander | 178 | 713 | 233287 |
David R. Williams | 178 | 2034 | 138789 |
David L. Kaplan | 177 | 1944 | 146082 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Deborah J. Cook | 173 | 907 | 148928 |