Showing papers by "University of Westminster published in 2010"

The Attractive Female Body Weight and Female Body Dissatisfaction in 26 Countries Across 10 World Regions: Results of the International Body Project I

Abstract: This study reports results from the first International Body Project (IBP-I), which surveyed 7,434 individuals in 10 major world regions about body weight ideals and body dissatisfaction. Participants completed the female Contour Drawing Figure Rating Scale (CDFRS) and self-reported their exposure to Western and local media. Results indicated there were significant cross-regional differences in the ideal female figure and body dissatisfaction, but effect sizes were small across high-socioeconomic-status (SES) sites. Within cultures, heavier bodies were preferred in low-SES sites compared to high-SES sites in Malaysia and South Africa (ds = 1.94-2.49) but not in Austria. Participant age, body mass index (BMI), and Western media exposure predicted body weight ideals. BMI and Western media exposure predicted body dissatisfaction among women. Our results show that body dissatisfaction and desire for thinness is commonplace in high-SES settings across world regions, highlighting the need for international attention to this problem.

Privacy, trust, and self-disclosure online

Abstract: Despite increased concern about the privacy threat posed by new technology and the Internet, there is relatively little evidence that people's privacy concerns translate to privacy-enhancing behaviors while online. In Study 1, measures of privacy concern are collected, followed 6 weeks later by a request for intrusive personal information alongside measures of trust in the requestor and perceived privacy related to the specific request (n = 759). Participants' dispositional privacy concerns, as well as their level of trust in the requestor and perceived privacy during the interaction, predicted whether they acceded to the request for personal information, although the impact of perceived privacy was mediated by trust. In Study 2, privacy and trust were experimentally manipulated and disclosure measured (n = 180). The results indicated that privacy and trust at a situational level interact such that high trust compensates for low privacy, and vice versa. Implications for understanding the links between privacy attitudes, trust, design, and actual behavior are discussed.

The effectiveness of interprofessional education: Key findings from a new systematic review

Abstract: Over the past decade systematic reviews of interprofessional education (IPE) have provided a more informed understanding of the effects of this type of education. This paper contributes to this literature by reporting an update of a Cochrane systematic review published in this journal ten years ago (Zwarenstein et al., 1999 ). In updating this initial review, our current work involved searches of a number of electronic databases from 1999-2006, as well as reference lists, books, conference proceedings and websites. Like the previous review, only studies which employed randomized controlled trials, controlled-before and-after-studies and interrupted time series studies of IPE, and that reported validated professional practice and health care outcomes, were included. While the first review found no studies which met its inclusion criteria, the updated review located six IPE studies. This paper aims to add to the ongoing development of evidence for IPE. Despite some useful progress being made in relation to strengthening the evidence base for IPE, the paper concludes by stressing that further rigorous mixed method studies of IPE are needed to provide a greater clarity of IPE and its effects on professional practice and patient/client care.

Production of polyhydroxyalkanoates: the future green materials of choice

Abstract: Polyhydroxyalkanoates (PHAs) have recently been the focus of attention as a biodegradable and biocompatible substitute for conventional non degradable plastics. The cost of large-scale production of these polymers has inhibited its widespread use. Thus, economical, large-scale production of PHAs is currently being studied intensively. Various bacterial strains, either wild-type or recombinant have been utilized with a wide spectrum of utilizable carbon sources. New fermentation strategies have been developed for the efficient production of PHAs at high concentration and productivity. With the current advances, PHAs can now be produced to a concentration of 80 g L?1 with productivities greater than 4 g PHA L?1 h?1. These advances will further lower the production cost of PHAs and allow this family of polymers to become a leading biodegradable polymer in the near future. This review describes the properties of PHAs, their uses, the various attempts towards the production of PHAs, focusing on the utilization of cheap substrates and the development of different fermentation strategies for the production of these polymers, an essential step forward towards their widespread use. Copyright © 2010 Society of Chemical Industry.

Unanswered questions: A preliminary investigation of personality and individual difference predictors of 9/11 conspiracist beliefs

Abstract: Given the widespread appeal of conspiratorial beliefs, it is surprising that very little empirical research has examined the psychological variables associated with such beliefs. In the present study, we examined individual and demographic predictors of beliefs in conspiracy theories concerning the September 11, 2001 (9/11) attacks on the World Trade Centre and Pentagon among a representative British sample of 254 women and men. Results of structural equation modelling showed that 9/11 conspiracist beliefs were positively associated with belief in other conspiracy theories, exposure to 9/11 conspiracist ideas, political cynicism, defiance of authority and the Big Five personality factor of Agreeableness. In total, a model including demographics, personality and individual difference variables explained over 50% of the variance in 9/11 conspiracist ideas. The implications of these findings for the literature on conspiracy theories are discussed.

The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder

Abstract: Background Childhood adversity has been associated with onset of psychosis in adulthood but these studies have used only general definitions of this environmental risk indicator. Therefore, we sought to explore the prevalence of more specific adverse childhood experiences amongst those with and without psychotic disorders using detailed assessments in a large epidemiological case-control sample (AESOP). Method Data were collected on 182 first-presentation psychosis cases and 246 geographically matched controls in two UK centres. Information relating to the timing and frequency of exposure to different types of childhood adversity (neglect, antipathy, physical and sexual abuse, local authority care, disrupted living arrangements and lack of supportive figure) was obtained using the Childhood Experience of Care and Abuse Questionnaire. Results Psychosis cases were three times more likely to report severe physical abuse from the mother that commenced prior to 12 years of age, even after adjustment for other significant forms of adversity and demographic confounders. A non-significant trend was also evident for greater prevalence of reported severe maternal antipathy amongst those with psychosis. Associations with maternal neglect and childhood sexual abuse disappeared after adjusting for maternal physical abuse and antipathy. Paternal maltreatment and other forms of adversity were not associated with psychosis nor was there evidence of a dose–response effect. Conclusions These findings suggest that only specific adverse childhood experiences are associated with psychotic disorders and only in a minority of cases. If replicated, this greater precision will ensure that research into the mechanisms underlying the pathway from childhood adversity to psychosis is more fruitful.

The cortisol awakening response in context.

Abstract: The cortisol awakening response (CAR) is a crucial point of reference within the healthy cortisol circadian rhythm, with cortisol secretion typically peaking between 30 and 45 min post awakening This chapter reviews the history of investigation into the CAR and highlights evidence that its regulation is relatively distinct from cortisol secretion across the rest of the day It is initiated by awakening, under the influence of the hypothalamic suprachiasmatic nucleus, and "fine tuned" by a direct neural input to the adrenal cortex by the sympathetic nervous system This chapter also examples the CAR in relation to other awakening-induced processes, such as restoration of consciousness, attainment of full alertness, changes in other hormones, changes in the balance of the immune system, and mobilization of the motor system, and speculates that there is a role for the CAR in these processes

Expression of integrin β1 by fibroblasts is required for tissue repair in vivo

Abstract: In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this process is poorly understood. Here, we show that mice containing a fibroblast-specific deletion of integrin β1 exhibit delayed cutaneous wound closure and less granulation tissue formation, including reduced production of new ECM and reduced expression of α-smooth muscle actin (α-SMA). Integrin-β1-deficient fibroblasts showed reduced expression of type I collagen and connective tissue growth factor, and failed to differentiate into myofibroblasts as a result of reduced α-SMA stress fiber formation. Loss of integrin β1 in adult fibroblasts reduced their ability to adhere to, to spread on and to contract ECM. Within stressed collagen matrices, integrin-β1-deficient fibroblasts showed reduced activation of latent TGFβ. Addition of active TGFβ alleviated the phenotype of integrin-β1-deficient mice. Thus integrin β1 is essential for normal wound healing, where it acts, at least in part, through a TGFβ-dependent mechanism in vivo.

Mosquito-Bacteria Symbiosis: The Case of Anopheles gambiae and Asaia

Abstract: The symbiotic relationship between Asaia, an α-proteobacterium belonging to the family Acetobacteriaceae, and mosquitoes has been studied mainly in the Asian malaria vector Anopheles stephensi. Thus, we have investigated the nature of the association between Asaia and the major Afro-tropical malaria vector Anopheles gambiae. We have isolated Asaia from different wild and laboratory reared colonies of A. gambiae, and it was detected by PCR in all the developmental stages of the mosquito and in all the specimens analyzed. Additionally, we have shown that it localizes in the midgut, salivary glands and reproductive organs. Using recombinant strains of Asaia expressing fluorescent proteins, we have demonstrated the ability of the bacterium to colonize A. gambiae mosquitoes with a pattern similar to that described for A. stephensi. Finally, fluorescent in situ hybridization on the reproductive tract of females of A. gambiae showed a concentration of Asaia at the very periphery of the eggs, suggesting that transmission of Asaia from mother to offspring is likely mediated by a mechanism of egg-smearing. We suggest that Asaia has potential for use in the paratransgenic control of malaria transmitted by A. gambiae.

Basel III: Is the Cure Worse than the Disease?

Abstract: Basel III will force banks to shift their business model from liability management, in which business decisions are made about asset volumes, with the financing found in short term wholesale markets as necessary, to asset management, in which asset volumes are constrained by the availability of funding. We find, contrary to what many have argued, that once there is a full adjustment, the costs of credit to low risk bank borrowers – the majority of customers – will be only moderately affected; but that there will a reduction in availability and higher cost at the riskier end of the credit spectrum. Alternative arrangements are therefore needed for financing of risky exposures if a fall in economic growth is to be avoided. In this context securitisation (broadly defined to include all forms of bank sponsored collateralised instrument, including covered bonds) will be of central importance. Re-establishing securitisation markets on a sounder footing appears essential, in order both to prevent a renewed credit contraction and to help prevent riskier borrowers from being cut off from credit. The shifts in bank balance sheets will also require substantial portfolio adjustments amongst long term institutional investors, from short term to long term debt and from debt to equity. The associated adjustment of both market prices and required returns can be accommodated but poses a substantial co-ordination problem and could take a long time. Finally the new liquidity rules could create new unintended systemic risks. In particular the proposed definition of eligible liquid assets is dangerously over-concentrated on government debt. The definition of should be broadened to give banks more scope to hold liquidity in the form of commercial claims; and central banks should clarify in what circumstances they will provide emergency liquidity assistance.

Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites

Abstract: This work investigated the effect of adding nanoparticulate (29 nm) bioactive glass particles on the bioactivity, degradation and in vitro cytocompatibility of poly(3-hydroxybutyrate) (P(3HB)) composites/nano-sized bioactive glass (n-BG). Two different concentrations (10 and 20 wt %) of nanoscale bioactive glass particles of 45S5 Bioglass composition were used to prepare composite films. Several techniques (Raman spectroscopy, scanning electron microscopy, atomic force microscopy, energy dispersive X-ray) were used to monitor their surface and bioreactivity over a 45-day period of immersion in simulated body fluid (SBF). All results suggested the P(3HB)/n-BG composites to be highly bioactive, confirmed by the formation of hydroxyapatite on material surfaces upon immersion in SBF. The weight loss and water uptake were found to increase on increasing bioactive glass content. Cytocompatibility study (cell proliferation, cell attachment, alkaline phosphatase activity and osteocalcin production) using human MG-63 osteoblast-like cells in osteogenic and non-osteogenic medium showed that the composite substrates are suitable for cell attachment, proliferation and differentiation.

Everyday life as a creative experience in cities

Abstract: Purpose – This paper aims to explore how overseas visitors experience off‐the‐beaten‐track areas and everyday life in London.Design/methodology/approach – Initially scoped through quantitative research using visitor surveys involving some 400 respondents, the study was subsequently developed through qualitative research: 49 semi‐structured interviews with visitors from a wide range of countries.Findings – These areas offer city visitors opportunities to create their own narratives and experiences of the city, and to build a cultural capital in a convivial relationship with other city users. At the same time, visitors contribute to the discovery of new areas for tourism ‐ and in some sense the creation of new places to visit.Research limitations/implications – Further research in other areas of London and in other world tourism cities is needed to develop ideas discussed here.Practical implications – Subtler forms of tourism marketing are required to develop the potential of areas like those discussed in t...

Saliva: Physiology and Diagnostic Potential in Health and Disease

Abstract: Saliva has been described as the mirror of the body. In a world of soaring healthcare costs and an environment where rapid diagnosis may be critical to a positive patient outcome, saliva is emerging as a viable alternative to blood sampling. In this review, we discuss the composition and various physiological roles of saliva in the oral cavity, including soft tissue protection, antimicrobial activities, and oral tissue repair. We then explore saliva as a diagnostic marker of local oral disease and focus particularly on oral cancers. The cancer theme continues when we focus on systemic disease diagnosis from salivary biomarkers. Communicable disease is the focus of the next section where we review the literature relating to the direct and indirect detection of pathogenic infections from human saliva. Finally, we discuss hormones involved in appetite regulation and whether saliva is a viable alternative to blood in order to monitor hormones that are involved in satiety.

Complexity, cues and relationships: Student perceptions of feedback

Abstract: This article discusses issues relating to the effectiveness of feedback and the student perspective. The study described provides rich data relating to student perceptions of useful feedback, their perceptions of feedback cues and their feelings about the importance of feedback relationships in the process. The outcomes suggest that written feedback is often not the most effective tool for helping students to improve their learning. The students in this study had much broader perceptions of useful feedback. Their perceptions challenge some of the assumptions that might be seen to underpin auditing approaches to monitoring the quality of feedback such as that of the National Student Survey.

The social impact of dizziness in London and Siena.

Abstract: Although dizziness is a common presenting symptom in general and hospital practice, its social cost is not known. We assessed the social and work life impact of dizziness on patients in two contrasting European cities, Siena and London. First, we developed the ‘Social life & Work Impact of Dizziness questionnaire’ (SWID), which was validated by administering it to 43 patients with dizziness and 45 normal controls and by correlating the results with the EQ-5D (Europe quality of life) questionnaire. The SWID and EQ-5D scores were worse in patients than controls (p < 0.001) and the two correlated significantly (r = 0.50 p < 0.001). Then two hundred consecutive patients per city attending tertiary specialised ‘dizzy patient’ clinics, one in London led by a neurologist, one in Siena led by an ear, nose and throat specialist (ENT), were investigated with SWID. Amongst the 400 patients, 27% reported changing their jobs and 21% giving up work as a result of the dizziness. Over 50% of patients felt that their efficiency at work had dropped considerably. The mean number of days off work attributed to the dizziness in the previous 6 months was 7.15 days. Social life was disrupted in 57% of all 400 patients. Factor analysis identified that detrimental effects on work, travel, social and family life combine to create a single factor accounting for much of the overall impact of their dizziness. Significant differences in some measures of handicap between London and Siena emerged, with London patients often faring worse. Reasons for these location differences include, as expected, a higher proportion of neurological patients in London than in Siena. However, factors related to city demographics and social cohesion may also modulate the impact on quality of life and working practice. Regardless of inter-city differences, these findings highlight the high social and economic impact of dizziness.

Harnessing e-Government Adoption in the SADC Region: a Conceptual Underpinning

Abstract: There has recently been an escalation of e-Government initiatives in the Southern African Development Community (SADC) region, with South Africa, Mauritius, Seychelles and Botswana leading the way towards this cause. Evidence indicates e-Government implementation projects in this region either fail or succeed. Therefore it is important that before actual implementation is commissioned, there is need to understand the different challenges that come with e-Government implementations such as investment risks, failure to be adopted by the general citizenry, abandoning already-commissioned e-Government activities, and so forth. Such problems can be avoided by putting in place a properly and carefully authored e-Government adoption strategy that takes care of the local context and the multi-dimensionality of e-Government. This paper, with strong reference to Davis' 1989 Technology Acceptance Model (TAM) theoretical underpinning, proposes a conceptual e-Government adoption model that may be commensurate with promoting the growth of e- Government in the SADC region. However, the limitation of this proposed model is that it has not been empirically tested and leaves room for its further validation. The paper follows up on the status of e-Government implementation in the SADC region by presenting two case studies that detail what interventions and initiatives have been put in place to encourage e-Government in Botswana and Zambia.

Insight, grey matter and cognitive function in first-onset psychosis.

Abstract: BACKGROUND: Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. AIMS: Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. METHOD: Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. RESULTS: The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. CONCLUSIONS: The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.

Oppressive Beliefs at Play: Associations among Beauty Ideals and Practices and Individual Differences in Sexism, Objectification of Others, and Media Exposure:

Abstract: In recent years, beauty ideals and practices have been explained almost exclusively using evolutionary psychological frameworks, to the exclusion of more proximate factors such as psychosocial and individual psychological variables. To overcome this limitation, we examined the associations among sexist beliefs, objectification of others, media exposure, and three distinct beauty ideals or practices. Across three studies, a total of 1,158 participants in a British community sample completed a series of scales that measured their attitudes toward women, hostility toward women, benevolent sexism, hostile sexism, their tendency to objectify others, media exposure, and endorsement of the thin ideal and (for women) body dissatisfaction (Study 1); height preferences in an other-sex partner (Study 2); and endorsement of cosmetic use (Study 3). Across the three studies, results supported the idea that sexist beliefs predicted beauty ideals and practices, although the strength of these associations varied according to the ideal or practice in question. These results support feminist critiques that beauty ideals and practices in Western societies are linked with sexist attitudes. Furthermore, our results suggest that programmes aimed to reduce or eliminate sexist attitudes, or that promote more gender egalitarian attitudes, may result in healthier beauty ideals and practices.

Anxiety, depression and acupuncture: a review of the clinical research

Abstract: Depression and anxiety together constitute a significant contribution to the global burden of disease. Acupuncture is widely used for treatment of anxiety and depression and use is increasing. The theoretical basis for acupuncture diagnosis and treatment derives from traditional Chinese medicine theory. An alternative approach is used in medical acupuncture which relies more heavily on contemporary neurophysiology and conventional diagnosis. Trials in depression, anxiety disorders and short-term acute anxiety have been conducted but acupuncture interventions employed in trials vary as do the controls against which these are compared. Many trials also suffer from small sample sizes. Consequently, it has not proved possible to accurately assess the effectiveness of acupuncture for these conditions or the relative effectiveness of different treatment regimens. The results of studies showing similar effects of needling at specific and non-specific points have further complicated the interpretation of results. In addition to measuring clinical response, several clinical studies have assessed changes in levels of neurotransmitters and other biological response modifiers in an attempt to elucidate the specific biological actions of acupuncture. The findings offer some preliminary data requiring further investigation.