Institution
Worcester Foundation for Biomedical Research
About: Worcester Foundation for Biomedical Research is a based out in . It is known for research contribution in the topics: Estrone & Estrogen. The organization has 2195 authors who have published 2646 publications receiving 115809 citations. The organization is also known as: Worcester Foundation for Experimental Biology.
Topics: Estrone, Estrogen, RNA, Sperm, Microtubule
Papers published on a yearly basis
Papers
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53 citations
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53 citations
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TL;DR: In this article, the compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds are provided.
Abstract: Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization complexes with DNA and can be used for any purpose which involves hybridizing an oligonucleotide to a DNA molecule, such as in antisense procedures. A method for enhancing oligonucleotide binding to a target is also provided. The method involves the step of hybridizing the target DNA with an oligonucleotide-peptide composition.
53 citations
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01 Jul 1988-Journal of Comparative Physiology A-neuroethology Sensory Neural and Behavioral Physiology
TL;DR: The results indicate an inverse relationship between the gonadal and hibernation cycles, and a probable role for gonadal steroids to influence the timing of the hibernation season.
Abstract: Torpor was monitored daily in adult male and female European hamsters (Cricetus cricetus) induced to hibernate by exposure to a cold environment (6 °C). The effect of photoperiodic manipulations or administration of exogenous gonadal steroids was examined in gonadectomized or intact hamsters.
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Gonadal regression occurred in all short day, but only in some long day, cold-exposed hamsters. Entry into hibernation was not observed until reproductive regression had occurred. Thus, gonadal atrophy appears to be a necessary precondition for hibernation.
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Castrated hamsters in the short day cold condition showed a significantly greater incidence of torpor than those in the long day cold condition. Hence, photoperiod affected torpor independently of its effect on the gonadal cycle.
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Testosterone, when administered via silastic capsules at near physiological levels, completely inhibited torpor in gonadectomized male and female hamsters hibernating in the short day cold condition.
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In ovariectomized females, torpor was unaffected by progesterone treatment, but partially inhibited by estradiol. A greater inhibition of torpor was observed when estradiol-primed females were administered both estradiol and progesterone simultaneously. Thus, the effect of both hormones may be functionally comparable to that of the single testicular hormone.
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Estradiol inhibited torpor to a greater extent in intact and ovariectomized female hamsters hibernating in long days than those in short days, suggesting an effect of photoperiod on responsiveness to estradiol.
53 citations
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TL;DR: It is demonstrated that rearing rats on a diet low in protein but adequate in all other respects significantly elevates brain tryptophan and amine concentrations, probably as a consequence of developmental alterations in plasma tryptophile availability.
52 citations
Authors
Showing all 2195 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert A. Weinberg | 190 | 477 | 240903 |
Harvey F. Lodish | 165 | 782 | 101124 |
E. J. Corey | 136 | 1377 | 84110 |
Peter Palese | 132 | 526 | 57882 |
Sten Orrenius | 130 | 447 | 57445 |
Aldons J. Lusis | 127 | 673 | 73786 |
Michel Goedert | 125 | 337 | 64671 |
Frederic D. Bushman | 119 | 442 | 84206 |
Robert H. Singer | 113 | 391 | 41493 |
Joel F. Habener | 112 | 427 | 43774 |
Ryuzo Yanagimachi | 102 | 438 | 40651 |
Jaak Panksepp | 99 | 446 | 40748 |
Hagan Bayley | 97 | 344 | 33575 |
John H. Hartwig | 96 | 260 | 30336 |
Joseph Avruch | 94 | 191 | 40946 |