Worcester Foundation for Biomedical Research

About: Worcester Foundation for Biomedical Research is a based out in . It is known for research contribution in the topics: Estrone & Estrogen. The organization has 2195 authors who have published 2646 publications receiving 115809 citations. The organization is also known as: Worcester Foundation for Experimental Biology.

The Transfer of Progesterone in the Ovarian Vascular Pedicle of the Sheep

Abstract: >3H]Progesterone, [14C]progesterone, and [125I]-bovine serum albumin were infused sequentially for 30-min periods into an ovarian vein close to the hilus of the ovary in sheep. Radioactivity was determined in plasma obtained from blood samples withdrawn simultaneously from the adjacent ovarian artery near the hilus of the ovary and from the aorta. During the infusion of labeled progesterone, radioactivity in ovarian arterial plasma showed a significantly greater increase compared to the increase in the equivalent volume of aortic plasma collected simultaneously. After the infusion of [125I]bovine serum albumin in the same manner as labeled progesterone, there was no observed difference in γ-radioactivity between plasma samples from the ovarian artery and the aorta. These results indicate the presence of a countercurrent transfer mechanism for progesterone between the ovarian vein and the ovarian artery. The concomitant infusion of prostaglandin F2n (PGF2a) into the ovarian vein did not decrease the transf...