Worcester Foundation for Biomedical Research

About: Worcester Foundation for Biomedical Research is a based out in . It is known for research contribution in the topics: Estrone & Estrogen. The organization has 2195 authors who have published 2646 publications receiving 115809 citations. The organization is also known as: Worcester Foundation for Experimental Biology.

Dynamin: motor protein or regulatory GTPase.

Abstract: Most of the genetic and cytochemical analysis of dynamin supports a role in membrane sorting, with little indication of a role for microtubules. None the less, evidence for such a role persists fromin vitro experiments. The most obvious solution to this dilemma seems to be that, despite evidence for specificity of the interaction with microtubules fromin vitro work, microtubules mimic a yet-to-be-identified cellular regulator of dynamin function. Alternatively, microtubules may participate in the early stages of endocytosis in a previously unrecognized manner, perhaps even indirectly. Resolving these issues will clearly be of paramount interest in the next phase of experimentation.

5-Hydroxytryptamine metabolism in rat brain and liver homogenates

Abstract: 1. The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities.2. In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD(+) to a greater extent than by NADP(+).3. In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH.4. In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.