Worcester Foundation for Biomedical Research

About: Worcester Foundation for Biomedical Research is a based out in . It is known for research contribution in the topics: Estrone & Estrogen. The organization has 2195 authors who have published 2646 publications receiving 115809 citations. The organization is also known as: Worcester Foundation for Experimental Biology.

In vitro response of functional experimental adrenal tumors to corticotropin ACTH.

Abstract: Summary1) Slices from transplants of 2 secretory adrenocortical tumors were incubated with and without ACTH. Incubation mixtures were extracted and the total Δ4-3-ketosteroids quantitatively determ...

Occurrence of vesicles in rabbit seminal plasma.

Abstract: Es konnte gezeigt werden, dass die 2 schnell sedimentierende Komponenten, isoliert aus Kaninchensamenflussigkeit von verschiedenen Zonen eines unterbrochenen Sucrosegradienten in elektronenmikroskopischen Aufnahmen vesikulare Strukturen darstellen. Die langsamer sedimentierende Komponente (85S) hat einen kleineren Durchmesser (507 A) und ist weniger dicht (1.16 g/cm3) als die schneller sedimentierende Komponente mit einem durchschnittlichen Durchmesser von 609 A und einer Dichte von 1.20 g/cm3. Die Dekapazitationsaktivitat in Samenflussigkeit kommt beiden zu und nicht nur wie bis jetzt angenommen wurde, der 85S Komponente. Zwei verschiedene Vesikeltypen wurden auch in der Samenflussigkeit von Mensch und Stier gefunden.

Effects of certain 19‐nor steroids upon reproductive processes

Abstract: Data on the effects of preparations containing no detectable estroge nic contaminant and also with an estrogen supplement are reported. Preparations used in previously reported studies have been found to contain varying amounts of estrogenic contaminant. 17-ethinyl-19-nortes tosterone norethynodrel and 17-ethyl-19-nortestosterone were tested and additional observations of pregnanediol and 17-ketosteroid excretion made in 4 groups of women on various regimens. No significant differences in effect on ovulation indices or on steroid output were found at the various dosages or with the several estrogens employed. However breakthrough bleeding was less when the dose was doubled. With 19-nor steroid plus estrogen breakthrough bleeding was less than with other preparations. Side-effects were more frequently noted when estrogen was added. These reactions decreased after the first cycle. When tablets were missed for several days significant premature bleeding occurred. No pregnancies occurred in the 1279 cycles when no tablets were missed. Pregnancies occurred in 2 of 282 cycles where 1-5 tablets had been missed and in 3 of 151 cycles where 6 or more tablets had been missed. Endometrial changes indicated a prompt progestational action. This was followed by a glandular regression accompanied by stromal stimulation. In postmedication cycles normal cyclic endometrial changes were rapidly reestablished.