Institution
Worcester Foundation for Biomedical Research
About: Worcester Foundation for Biomedical Research is a based out in . It is known for research contribution in the topics: Estrone & Estrogen. The organization has 2195 authors who have published 2646 publications receiving 115809 citations. The organization is also known as: Worcester Foundation for Experimental Biology.
Topics: Estrone, Estrogen, RNA, Sperm, Microtubule
Papers published on a yearly basis
Papers
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TL;DR: The results show that viral gene products are not required for maintenance of neoplastic transformation and suggest that in lymphoid tumors, an ALV provirus is integrated adjacent to a specific cellular gene, and the insertion of the viral promoter adjacent to this gene results in its enhanced expression, leading to neoplasia.
484 citations
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TL;DR: The properties of high reactivity under mild conditions, long solution half-life, and the radioactive label make [35S]dithiobis(succinimidyl propionate) a particularly useful and versatile probe of extended structures in a variety of biological systems.
472 citations
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13 Feb 1991TL;DR: A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method is described in this paper.
Abstract: A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.
472 citations
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TL;DR: Findings identify a direct interaction between two specific component polypeptides and support a role for dynactin as a dynein "receptor" and suggest, however, that this interaction must be highly regulated.
Abstract: Cytoplasmic dynein is a retrograde microtubule motor thought to participate in organelle transport and some aspects of minus end-directed chromosome movement. The mechanism of binding to organelles and kinetochores is unknown. Based on homology with the Chlamydomonas flagellar outer arm dynein intermediate chains (ICs), we proposed a role for the cytoplasmic dynein ICs in linking the motor protein to organelles and kinetochores. In this study two different IC isoforms were used in blot overlay and immunoprecipitation assays to identify IC-binding partners. In overlays of complex protein samples, the ICs bound specifically to polypeptides of 150 and 135 kD, identified as the p150Glued doublet of the dynactin complex. In reciprocal overlay assays, p150Glued specifically recognized the ICs. Immunoprecipitations from total Rat2 cell extracts, rat brain cytosol, and rat brain membranes further identified the dynactin complex as a specific target for IC binding. using truncation mutants, the sites of interaction were mapped to amino acids 1-123 of IC-1A and amino acids 200-811 of p150Glued. While cytoplasmic dynein and dynactin have been implicated in a common pathway by genetic analysis, our findings identify a direct interaction between two specific component polypeptides and support a role for dynactin as a dynein "receptor". Our data also suggest, however, that this interaction must be highly regulated.
467 citations
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TL;DR: Microinjection of neuropeptide Y into the suprachiasmatic region of the hypothalamus phase shifted the circadian activity rhythm of hamsters housed in constant light and suggested that NPY functions as a chemical messenger important for the light-dark cycle entrainment of circadian rhythms.
454 citations
Authors
Showing all 2195 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert A. Weinberg | 190 | 477 | 240903 |
Harvey F. Lodish | 165 | 782 | 101124 |
E. J. Corey | 136 | 1377 | 84110 |
Peter Palese | 132 | 526 | 57882 |
Sten Orrenius | 130 | 447 | 57445 |
Aldons J. Lusis | 127 | 673 | 73786 |
Michel Goedert | 125 | 337 | 64671 |
Frederic D. Bushman | 119 | 442 | 84206 |
Robert H. Singer | 113 | 391 | 41493 |
Joel F. Habener | 112 | 427 | 43774 |
Ryuzo Yanagimachi | 102 | 438 | 40651 |
Jaak Panksepp | 99 | 446 | 40748 |
Hagan Bayley | 97 | 344 | 33575 |
John H. Hartwig | 96 | 260 | 30336 |
Joseph Avruch | 94 | 191 | 40946 |