Showing papers in "Alcohol in 2020"

TL;DR: This data indicates that in Iran, alcohol poisoning was reported and led to the death of hundreds of people in several provinces after a rumor circulated in the country that drinking alcohol can cure or prevent being infected by COVID-19.

TL;DR: The high morbidity and mortality associated with methanol poisoning preceding and exacerbated by COVID-19 highlight the potential population level health impacts of the implementation of evidence-based education and harm reduction strategies focused on alcohol use across Iran.

TL;DR: The results of this study showed that the consideration of combination between attachment styles and alexithymia is of significance in the diagnosis and therapy of alcohol use disorders.

TL;DR: It is found that moderate consumption of NAB has a positive effect on human health by supplementation of biological active polyphenol and phenolic acids, and by enrichment of the gut microbiota diversity with beneficial bacteria; while the presence of alcohol in AB interferes with this effect in this study.

TL;DR: There is no conclusive evidence for spirits being associated with more harm, but some evidence supports for certain outcomes such as injuries and poisonings a potential excess risk for spirits consumption due to rapid ethanol intake and intoxication.

TL;DR: The results point to a likely liver-brain functional partnership and suggest that future strategies to alleviate hepatic and/or neuroinflammatory impacts of chronic AUD may result in improved cognitive outcomes.

TL;DR: The knowledge of the nature of the phenomenon of alcohol-induced thrombocytopenia in clinical environment allows more rational decisions and the attention of clinicians should be drawn to the importance of results of blood tests routinely collected on admission.

TL;DR: Alcohol preferring P rats and Wistars are used to examine drinking despite negative consequences in the form of an aversive bitter taste stimuli produced by quinine to indicate that following about 8 weeks of alcohol consumption P rats exhibit aversion resistant drinking.

TL;DR: The role of zinc in gut-liver axis perturbations associated with ALD, highlighting the importance of dietary fat in ALD pathogenesis and hepatic n6 and n3 PUFA oxylipin pattern associated with ethanol-induced liver injury, and deliberating on new biomarkers for alcoholic hepatitis and their implications for diagnosis and therapy are addressed.

TL;DR: The use of a divider during alcohol intake sessions had no impact on alcohol intake in female rats and may not exert long-term influences in male rats.

TL;DR: Phenobarbital is an effective adjunct to symptom-triggered lorazepam in severe alcohol withdrawal in the ICU with no significant difference in adverse events.

TL;DR: It is reported that CIE differentially disrupts mGlu2-mediated long-term depression in the DLS vs. dorsomedial striatum, and enhancement of mGLU2 activity is identified as a strategy to reverse the effects of adolescent alcohol exposure on DLS physiology.

TL;DR: It is suggested that the intermittent access model does not reliably induce negative affective behaviors on these tasks, and that behavior in female and male mice differ across these tests, suggesting that intermittent alcohol drinking may induce a mild form of behavioral disinhibition.

TL;DR: Results demonstrate that coincubation of sperm with epididymal EV preparations is sufficient to impart intergenerational effects of ethanol through the male germline, and this mechanism may generalize to the intergenerations effects of a wide variety of paternal preconception perturbations.

TL;DR: From the analysis of longitudinal data, drinking alcohol is still an important risk factor for hypertension among Chinese subjects, especially those who drink high frequency, and the risk of hypertension increased with the increase in drinking frequency.

TL;DR: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-γ and MCP-1) and lower levels of anti-inflammatory inflammation (TGF-β1), which may represent a link between alcohol use and alcohol-related morbidity.

TL;DR: The role of ayahuasca in mediating cFos expression in other selected brain regions and its relationship with the serotoninergic/dopaminergic systems and drug addiction needs further investigation.

TL;DR: The results reveal a complex relationship between stress history and ethanol intake in adolescence on outcomes in adulthood, and a stress history moderated the negative consequences of ethanol access.

TL;DR: The results of these studies suggest that chronic exposure to alcohol induces changes in neurovascular coupling that are region dependent.

TL;DR: Individual factors as the influence of drinking patterns of siblings and friends, and more alcohol access opportunities are associated with adolescents' risky alcohol consumption, which is higher among rural adolescents than among urban youth.

TL;DR: Alcohol-induced changes in BDNF and 5-HT systems were revealed in the raphe nuclei area, as well as in the cortex, hippocampus and amygdala, suggesting that BDNF/5-HT interaction contribute to the mechanism underlying chronic alcohol-induced neurodegenerative disorders.

TL;DR: In the exploratory data, acute alcohol challenge (120 mg/dL) elicits dynamic changes in the pro-inflammatory molecules IL-8 and TNF-α, which help inform the temporal profile of cytokine response to alcohol, and identify IL- 8 as a cytokine of interest for future studies of periphery-brain immune communication.

TL;DR: It is found that male mice showed a strong mechanical allodynia following 8 weeks of intermittent ethanol drinking at 72 hr of withdrawal, compared to water Control mice, regardless of the diet and hence of the different amount of ethanol consumed.

TL;DR: An approach using the clinical notes with NLP and supervised machine learning may better identify alcohol misuse cases than conventional methods solely relying on billing diagnostic codes.

TL;DR: A significant interaction effect of the 33-SNP AD PRS and alcohol consumption on this AD Cortical Thickness Signature is found, but it is unclear whether this interaction is due to a detrimental or beneficial effect of moderate alcohol consumption in those with the highest genetic risk for AD.

TL;DR: In the structural equation model, the social norm variables (descriptive and injunctive norms) were associated with higher levels of blackout intentions and recent blackout history, and the impact of adjusting social norms on both the intention to blackout and experiencing blackouts was assessed.

TL;DR: In mice both alcohol AUC and peak alcohol concentration correlate well with an important biological effect, activation of the hypothalamic-pituitary-adrenal axis, as indicated by increased corticosterone AUC values.

TL;DR: The study indicates that, during adolescence and youth, psychological distress is associated with experiencing negative consequences of alcohol consumption and suggested that greater levels of psychological distress may underlie the facilitating effect of an early age of drinking onset upon alcohol drinking patterns.

TL;DR: Even moderate drinking could promote hepatic fibrosis in non-alcoholic fatty liver disease subjects; on the contrary, NAFLD drinkers should not be recommended for even moderate amount of alcohol.

TL;DR: Observations suggest that acyl-ghrelin, a primary gut-brain signaling hormone, is elevated by ethanol during early adolescence independent of administration route, and in gender-dependent fashion.