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Showing papers in "Biochimica et Biophysica Acta in 1979"


Journal ArticleDOI
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.

3,842 citations


Journal ArticleDOI
TL;DR: The possible functional roles of lipids are reviewed in terms of previous models such as the fluid mosaic model of Singer and Nicolson or the earlier unit membrane model so that the requirement for an alternative approach becomes apparent.

1,751 citations


Journal ArticleDOI
TL;DR: Liposomes of defined size and homogeneity have been prepared by sequential extrusion of the usual multilamellar vesicles through polycarbonate membranes, which can double the encapsulation efficiency of the liposome preparation.

1,115 citations




Journal ArticleDOI
TL;DR: I. Membranelytic properties of lysophosphat ides: Effects on cell fusion, temperature, and membrane-associated enzymes.

589 citations


Journal ArticleDOI
TL;DR: The α-32P-labeled ribo- and deoxyribonucleoside triphosphates prepared by this method should be very useful in studies on nucleic acid structure and metabolism and the [γ- 32P]nucleosid triph phosphates should be useful in the study of phosphate transfer systems.

530 citations



Journal ArticleDOI
TL;DR: The results indicated that activated Protein C can inhibit Factor Xa initiated clotting by degrading Factor Va by inhibiting prothrombin activation and protecting Factor Va fromactivated Protein C inactivation by the presence offactor Xa.

447 citations




Journal ArticleDOI
TL;DR: A detailed study of the photo-induced decline in chlorophyll a fluorescence intensity (Kautsky phenomenon) in coupled isolated chloroplasts from a high level (P) to a low stationary level (S) is presented and a linear relationship between P leads to S quenching and intrathylakoid H+ concentration was found.

Journal ArticleDOI
TL;DR: A comparison of monolayer and bilayer systems on the basis of the absolute value of the molecular area of the phospholipid in the bilayer gel phase and the change in area at the bilayers and monolayers transition leads to the following conclusions.




Journal ArticleDOI
TL;DR: The chemiosmotic and local proton hypotheses are tested and results from the measurement of chromatophores and submitochondrial particles suggest that the proton-proton coupling in electron transport phosphorylation is driven by proton starvation.


Journal ArticleDOI
TL;DR: Incorporation of the matrix protein (porin) from the outer membrane of Escherichia coli into black lipid films results in the formation of ion-permeable pores with a single-pore conductance of the order of 2 nS.

Journal ArticleDOI
TL;DR: In this article, the lysine-binding sites in the plasmin A-chain were found to be responsible for the interaction with α 2 -antiplasmin.

Journal ArticleDOI
TL;DR: The purification of a plasminogen activator from human uterine tissue showed a strong tendency to adsorb to surfaces and could be effectively prevented by Tween-80.

Journal ArticleDOI
TL;DR: The results obtained allowed us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.

Journal ArticleDOI
TL;DR: Evidence from fluorescence, circular dichroism and 1H nuclear magnetic resonance experiments indicates that the conformation of melittin bound to micelles of various detergents or of diheptanoyl phosphatidylcholine is largely independent of the type of lipid and furthermore appears to be quite closely related to the conformational studies of membrane proteins.


Journal ArticleDOI
TL;DR: Partially degraded hyaluronate was coupled to AH-Sepharose 4B using carbodiimide and the derivatized gel was used to purify components of the hyAluronate-proteoglycan complex of cartilage.

Journal ArticleDOI
TL;DR: Phosphatidate production reflects the generation of diacylglycerol by C-type phospholipase degradation of phosphatidylinositol, and may participate in the membrane modification related to the early changes in platelet shape, release reactions or aggregation which occur on stimulation.

Journal ArticleDOI
TL;DR: It is proposed that intercalation-induced distortion of the DNA helix leads to strand scission by a nuclease which becomes bound to one terminus of the break so as to form a DNA-protein crosslink.

Journal ArticleDOI
TL;DR: It is suggested that the phospholipids at the alveolar/air interface exhibit both thermodynamic (equilibrium) and kinetic forces during the course of a respiratory cycle.

Journal ArticleDOI
TL;DR: Isotonic suspensions of erythrocytes exposed to intense electric fields for a duration in microseconds showed time-dependent increase in the conductivity, indicating that the induced membrane conductance is strongly dependent on the membrane potential.

Journal ArticleDOI
TL;DR: The results indicate that O( 6)-methylguanine is capable of miscoding with a DNA polymerase but the miscoding is competitive with the normal incorporation of dCMP: when the 5'-triphosphate precursors are present in equal amounts approximately one O(6)-methylGuanine in three miscodes leading to the incorporation ofdTMP.