Showing papers in "Cellular Immunology in 1982"

TL;DR: Experimental autoimmune encephalomyelitis (EAE) in mice is dependent upon the use of Bordetella pertussis suspensions as an adjuvant and the efficacy of different batches and strains of B. pertussedis in the expression of EAE closely correlates with the vasoactive amine sensitization activity of each material tested.

TL;DR: BCG-immunized volunteers received intradermal injections of PPD to produce delayed-type hypersensitivity reactions and the disposition of mononuclear cells one to another and their relationship to the Langerhans cells were revealed.

TL;DR: It is indicated that homogeneous recombinant interferon has potent in vitro immunomodulating effects and thus provide a basis for carefully examining the in vivo effects of this protein on host defenses in forthcoming clinical trials with cancer patients.

TL;DR: A bacterial antitumor and immunopotentiating agent, OK-432, induced Interferon in the spleen cell cultures but not in the thymus cell cultures of various inbred strains of mice.

TL;DR: The human T cell subset(s) responsible for production of interleukin 2 (IL 2) was investigated in this article, where highly purified T4+ and T8+ T lymphocytes were stimulated with mitogens and alloantigens.

TL;DR: The most prominent effect of prednisolone was to retard recirculating lymphocytes within the tissues to which they are normally distributed by the blood, namely the bone marrow, the spleen, and the lymph nodes.

TL;DR: In this paper, the influence of 15-hydroxy-eicosatetraenoic acid (15-HETE) on mitogenesis in spleen lymphocyte cultures was examined.

TL;DR: In this article, the influence of Toxoplasma gondii infection on mouse natural killer (NK) cells was examined in peritoneal exudate cells (PC) and spleen cells (SC).

TL;DR: It was noted that small doses of a monoclonal NP-specific IgM antibody failed to enhance the response to NP-SRC, and that the role of the variable region in feedback inhibition is sufficiently explained by its affinity for the antigen.

TL;DR: While androgen enhances Coxsackie B-3 virus heart disease, estrogen may be protective and enhance mortality levels or T-lymphocyte-mediated cytotoxicity of infected myofibers.

TL;DR: Highly enriched populations of LGL are isolated, which are virtually devoid of mature typical lymphocytes, in comparison to T cells which contain greater than 95% sheep erythrocyte-forming cells and are devoid of L GL and NK K activities.

TL;DR: The results of direct screening for functional blockade support the important role of Lyt-2,3 and LFA-1 molecules in T-cell-mediated cytolysis.

TL;DR: The studies emphasize the unique role of Ly-1+2+ T cells in immunity to Brucella and indicate the usefulness of these techniques in dissecting out those components of the immune response which contribute to recovery from infection.

TL;DR: At least 80% of PR8 (H1N1) influenza-specific cytotoxic T cells are lytic for both HK (H3N2)- and PR8-infected target cells, confirming that these experiments demonstrate the feasibility of quantitating different influenza-immune CTL specificities at a stage very close to removal of cells from the animal.

TL;DR: This study demonstrates that production and secretion of IL-1 do not require participation of intact components of the cytoskeleton, and suggests that the complex immunosuppressive effects of glucocorticoids could partly result from their capability to controlIL-1 production.

TL;DR: B-Cell activity in weanling Lewis rats was inhibited by injections of goat anti-rat mu-chain antiserum from birth on, as demonstrated by markedly reduced or absent myelin basic protein (MBP) binding activity of sera.

TL;DR: The finding that macrophage activation results from primary S. mansoni infection itself suggests that these cells may play a major role in acquired immunity to this parasite.

TL;DR: It is demonstrated that an HLA-restricted EB virus-specific cytotoxic T-cell response can indeed be induced in vitro by stimulation of fresh lymphocytes with autologousEB virus-transformed cells providing cocultures are set up at the correct R:S ratio.

TL;DR: These experiments show that the same monocyte cell type can mediate both nonspecific and antibody-dependent lysis of tumor targets, and the U937 line can be used as a model for detecting nonlymphoid as well as lymphoid factors stimulating differentiation or maturation of human monocytic cells.

TL;DR: The major role of endogenous PGE in polyclonal Ig production in vitro is to tonically inhibit a radiosensitive, OKT8(+) suppressor T cell, which provides one explanation for decreased suppressor cell function in elderly subjects.

TL;DR: Positive selection studies confirmed the findings of depletion of T-cell helper activity using antibody and complement, and the 9.3 − subsets were found to be consistent suppressor cells.

TL;DR: It is found that, within the conditions of these experiments, all IgG isotypes were influenced equally by the presence or absence of T lymphocytes, and a division of TD antigens into two types is proposed based upon the ability to stimulate responses in the CBA/N mouse.

TL;DR: The susceptibility of the BALB/c mouse in vivo may be attributable to the early contact of T-lymphocyte subsets in BALB-c mice with the high-antigen load maintained in this discrete skin cell population.

TL;DR: The results indicate that the early deaths of C3H/HeJ mice following S. typhimurium challenge reflect a failure of their macrophages to limit the growth of these gram-negative bacteria.

TL;DR: Splenic B cells harvested 2 weeks after immunization of C57BL/6 mice with a high dose of sheep erythrocytes, when transferred to normal syngeneic recipients, suppressed the recipient's IgM and IgG plaque-forming cells (PFC) responses to SRBC.

TL;DR: It appears that the present treatment protocol prevents lymphocytes from entering the central nervous system parenchyma, suggesting an age-dependent difference in the immune response.

TL;DR: Interleukin 2 or T-cell growth factor induced the production of immune interferon (IFN γ) in C57B1/6 mouse spleen cell cultures, and enhanced mitogen-induced IFn γ production in both spleen cells and thymocytes.

TL;DR: It is demonstrated that a suppressor cell population, capable of suppressing the primary immune response of normal syngeneic mouse splenocytes to heterologous sheep erythrocytes (SRBC), is activated by Staphylococcal enterotoxin B.

TL;DR: The results indicate that the virus either impairs the expression of membrane-associated antigen-presenting components (such as the Ia determinants), thus damaging antigen presentation, or is responsible for the elimination of Ia-positive cells from the peritoneum.