Showing papers in "Diabetes & Metabolism in 2019"

TL;DR: Anti-inflammatory compounds such as intravitreal glucocorticoids, topical non-steroidal anti-inflammatory drugs (NSAIDs), antioxidants, inflammatory molecule inhibitors, renin-angiotensin system (RAS) blockers and natural anti- inflammatory therapies may all be considered to reduce the rate of administration of antineovascularization agents in the treatment of DR.

TL;DR: Long-term adherence to a high-fibre, polyphenol-enriched and vegetable-protein-based diet provides benefits for the composition of faecal microbiota, and may offer potential therapies for improvement of glycaemic control, dyslipidaemia and inflammation.

TL;DR: Through a comprehensive phase 3 clinical trial program, a detailed understanding is understood of semaglutide's efficacy, safety, cardiovascular effects and comparative role in the treatment of type 2 diabetes.

TL;DR: The substantial increase in diabetes-related burden represents an ongoing challenge, given the rapidly ageing Chinese population, and a targeted control and preventative strategy needs to be developed at risk factor level to reduce this burden.

TL;DR: A profound shift to a world where patients, healthcare professionals and research scientists can consider various key parameters at thousands of time points simultaneously will profoundly change the way diabetes is prevented, managed and characterized in patients living with diabetes, as well as how it is scientifically researched.

TL;DR: A positive effect of SGLT2 inhibitors on NAFLD complements their already well-known effects on cardiovascular and chronic kidney diseases and suggests a mechanism beyond the reduction of hyperglycaemia and body weight.

TL;DR: It is shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN and every 1-cm decrease in waist circumference and 1-μmol/L increase in nitric oxide was associated with reductions in urine albumin/creatinine ratio.

TL;DR: In DN patients, the complement system is activated and, of the three possible complement pathways, activation of the lectin and alternative pathways is associated with renal damage.

TL;DR: Findings suggest that myokine secretion is an important factor contributing to the development of muscle metabolic defects during T2D, and potential therapeutic targets for the management of this disease are uncovered.

TL;DR: Clinical evidence is strongly supports the idea that hyperglycaemia and glucose overload play a central role in the pathophysiology of diabetic cardiomyopathy, based on clinical evidence from mechanistic studies as well as several large clinical trials.

TL;DR: Urinary EV miRNAs correlate with the degree of MIC, and may also serve as non-invasive 'liquid biopsies' to stratify patients at risk of developing MAC and to monitor treatment efficacy.

TL;DR: Further studies with renal outcomes as primary endpoints are now awaited in T2DM patients at high risk of DKD, including trials evaluating the potential add-on benefits of combined GLP-1RA-SGLT2i therapies.

TL;DR: In post-menopausal women with T2DM, the presence of NAFLD and clinically significant fibrosis was strongly associated with a low bone turnover, which may reflect the presenceof qualitative bone abnormalities.

TL;DR: A meta-analysis has indicated that SGLT2 inhibitors do not increase risk of bone fracture compared with placebo in patients with T2DM, however, these findings now need to be confirmed in well-designed RCT studies.

TL;DR: In post-menopausal women with T2DM, the G/G genotype of rs738409 in the PNPLA3 gene was strongly associated with lower eGFRCKD-EPI and higher prevalence of CKD.

TL;DR: Information is provided on the different kinds of beta-cell replacement, their benefit-risk ratios and indications for each type of transplantation, according to type of diabetes, its control and association with end-stage renal disease.

TL;DR: Investigating C1q and C3c deposition as seen on renal histopathology as well as its association with clinical and pathological parameters, in DN patients found that complement deposition is associated with more severe kidney damage in patients with DN.

TL;DR: Decreasing basal insulin infusion rate by 80% up to 40 minutes before exercise onset is insufficient to reduce exercise-induced hypoglycaemia.

TL;DR: The results suggest that, in AMI patients with poorly controlled diabetes, GV is associated with CAD severity beyond chronic hyperglycaemia, and early evaluation of GV might contribute to the identification of those diabetes patients at high risk, and serve as a therapeutic target for both primary and secondary prevention.

TL;DR: While a strategy including early measurement of fasting plasma glucose during pregnancy increases the incidence and care of hyperglycaemia during pregnancy, it may not significantly improve pregnancy outcomes.

TL;DR: Hypoglycaemia may play an intermediary role in accentuating the link between glycaemic variability and vascular events, and is not a 'forever' phenomenon, as demonstrated in the 15-year follow-up of the Veterans Affairs Diabetes Trial (VADT).

TL;DR: In this article, a literature review was performed to identify clinical, psychosocial and technical issues raised by the artificial pancreas and subsequently analyzed them through a common bioethics framework.

TL;DR: NAFLD is associated with significant reductions of both FEV1 and FVC in Asian and United States adults, and such small, but significant, reductions of lung volumes at baseline may be also associated with increased NAFLD incidence in Asian individuals.

TL;DR: It is suggested that regular re-evaluations of treatment, including response, tolerability, adherence, cost and quality of life, are necessary.

TL;DR: Short and long sleep duration are associated with a lower insulin sensitivity, suggesting that sleep plays an important role in insulin resistance and may provide the link with development of type 2 diabetes.

TL;DR: A reduced risk of COPD is observed in metformin users with T2D, as observed in unmatched cohort and matched pair cohort.

TL;DR: Pre-operative OPN serum levels might be useful for predicting 3-year T2DM remission independently of weight loss in patients undergoing bariatric surgery.

TL;DR: Obese people with healthy livers are characterized by intact glucose homoeostasis, lower pro-inflammatory cytokine levels, and higher adiponectin and leptin concentrations compared with obese people with NAFLD.

TL;DR: Non-R482 carriers present more frequently with arrhythmias than R482 carriers, suggesting that follow-up for laminopathies could be adjusted for genotype, and coronary artery disease should not be overlooked.

TL;DR: Metformin use is associated with a lower risk of NHL compared with non-metformin antidiabetics in both the intention-to-treat and the per-protocol analyses.