Showing papers in "European Journal of Cancer and Clinical Oncology in 1988"

TL;DR: Both hypotheses suggest that the risk of breast cancer could be reduced by delaying the onset of regular ovulatory menstrual cycles and by minimizing the therapeutic use of oestrogens, and possibly of progestagens, in postmenopausal women.

TL;DR: It is concluded that chemotherapy did not contribute significantly to either local control or survival as compared to radiotherapy alone and the combined regimen with stage IIIM0 disease.

TL;DR: Analysis of the morphology, ultrastructure, karyotype and immunohistochemical properties of these two cell lines demonstrated that they are both well characterized, uncontaminated by HeLa cells, and do in fact correspond to transformed epithelial cells that have conserved certain characteristics of the original Malpighian epithelium.

TL;DR: A pilot study with amphotericin B incorporated in sonicated liposomes (ampholiposomes) made of egg phosphatidylcholine, cholesterol and stearylamine in a molar ratio 4:3:1 was performed in cancer patients with fungal infections, concluding that ampholiposome have a better therapeutic index than Fungizone.

TL;DR: The complication rate of total thyroidectomy for suspected or proven thyroid cancer was reviewed to determine the complication rate and it was found that one of the permanent complications, the case of permanent hypoparathyroidism, could have been avoided by a lesser procedure.

TL;DR: LV-5-FU bolus and continuous infusion is safe and has definite activity in metastatic colorectal cancer.

TL;DR: A general conclusion from these trials is that studies of the management of infection in GCP should include sufficient numbers of eligible patients to allow for evaluation of bacteremic patients at highest risk of death.

TL;DR: It is demonstrated that cancer regression is also accompanied by a significant induction of tumor necrosis factor in macrophages in the tumor area, suggesting a possible mechanism of tumor destruction.

TL;DR: In this paper, the authors make the assumption that NC is a worthwhile category of response if the overall time to progression and survival of this group is not significantly different from patients with partial remissions (PR).

TL;DR: The data strongly suggest that patients receiving alpha-interferon therapy should be closely monitored for the possible development of thyroid dysfunction and that thyroid antibody determination can greatly help to predict overt thyroid clinical abnormalities.

TL;DR: The conclusion is that toremifene is an effective, safe and in clinical practice easily applied choice of treatment in estrogen receptor positive advanced breast cancer.

TL;DR: Data suggest that HPC may be useful in the treatment of human cancer, and a single high dose of HPC was considerably more active against the DMBA tumor.

TL;DR: In patients with papillary cancer the presence of small anaplastic foci and/or greater than 25% solid structures was correlated with a reduced survival rate, and the study underlines the importance of distinguishing, histologically, between papillary and follicular cancer.

TL;DR: The data suggest that EGF-R could identify a class of more aggressive breast tumors endowed with a higher metastatic potential and may therefore represent an unfavorable prognostic parameter in breast cancer.

TL;DR: This study showed that CHIP or CBDCA in combination with cycloph phosphamide was less toxic than cisplatin/cyclophosphamide therapy with regard to alopecia, degree and duration of nausea and vomiting, renal toxicity, neurotoxicity and anaemia.

TL;DR: Concomitant administration of the neurotrophic ACTH4-9 analog, ORG.2766 during a first cisplatin treatment period results in a better resistance against neurotoxicity in a second exposure period and was shown not to hamper the anti-tumor effect of cisPlatin in mice, carrying implanted tumor cells from a FMa human tumor line.

TL;DR: Intraperitoneal injections of 1 ml of 50 mM AMP, ADP or ATP in saline, yielded elevated blood and plasma levels of ATP which lasted for several hours in both strains of mice, demonstrating growth-inhibitory activities of adenine nucleotides against tumor cells in vitro, have previously been demonstrated.

TL;DR: In a randomized study 31 patients with advanced cancer disease in whom classical anticancer therapy had been abandoned received a daily combination of subcutaneous histamine and oral H2-antihistaminics, treatment induced a marked clinical improvement as shown by a large rise in performance status (Karnofsky scale).

TL;DR: The main finding to emerge was that after standardizing for all the other variables increasing parity was related to a step-wise reduction in blood prolactin levels, which implies this effect is permanent and could therefore be that the protective effect on breast cancer risk of multiparity and early first pregnancy could be mediated by such a life-long reduction in prolactIn levels.

TL;DR: In a series of 313 neck dissections for thyroid carcinoma as mentioned in this paper, only three patients with papillary or follicular carcinoma, which was resectable, treated by thyroidectomy and modified neck dissection died of disease.

TL;DR: The crude association between nitrate concentration in drinking water and rate of endogenous nitrosation in individuals is only weakly positive and not quite statistically significant (P = 0.08), and the experimental design is likely to underestimate the effect of nitrate in drinkingWater relatively to nitrates in the diet.

TL;DR: This study demonstrates the prognostic importance of DNA-FCM-derived information in NSCLC using a multivariate analysis; however further prospective studies in larger patient populations are needed.

TL;DR: There was a good correlation between DNA breakage and cytotoxicity, but the relationship between drug concentration and number of protein-DNA cross-links was non-linear and differed from that of amsacrine and CI-921.

TL;DR: This paper applies an index of carcinogenic potency to published data on acute non-lymphocytic leukemia following therapy with cytotoxic drugs used as single agents, and the broader implications for quantitative cancer risk prediction are discussed.

TL;DR: It is concluded that BGP measurements reflect a wide variability of bone formation rates in metastatic bone disease, particularly when metastases were sclerotic in appearance, but in patients with hypercalcaemia the low BGP levels suggest uncoupling of bone resorption and formation.

TL;DR: Preliminary pharmacokinetics suggest that didemnin B is sequestered or rapidly converted to a metabolite not identified by the antibody used in the radioimmunoassay, and further evaluation will be performed during Phase II studies.

TL;DR: A questionnaire for patient self-administration with 29 variables was designed including the following subjects: psychosocial well-being, medical side-effects, activities of daily living and physical performance and showed a high degree of validity for the majority of the items studied.

TL;DR: Ten patients with metastatic small cell lung cancer in the brain, shown by CT scan at time of diagnosis, were treated with systemic combination chemotherapy, with significant responses on CT scans as well as neurologic improvement demonstrated in all evaluable patients.