Showing papers in "Experimental and Toxicologic Pathology in 2015"

TL;DR: Silver nanoparticles had the ability for inducing various hepatic histopathological alterations indicating hepatocytotoxicity presumably by oxidative stress, in addition to the induction of chromosomal aberrations in bone marrow cells denoting the genotoxicity of nanosilver particles.

TL;DR: Data are provided to provide a better understanding of the possible effects of Fusarium toxins, alone or in combinations on the morphology of the intestine and lymphoid organs, which would contribute to the risk assessment of these toxins.

TL;DR: The present study demonstrated the renoprotective nature of betaine by attenuating the pro-inflammatory and apoptotic mediators and improving antioxidant competence in kidney tissues of cisplatin treated rats.

TL;DR: Oral administration of idebenone, carnosine and vitamin E alleviated the hazards of TiO2 NPs with the combination regimen showing a relatively higher effect and oxidative stress could be regarded as a key player in TiO1 NPs-induced liver injury.

TL;DR: GTE played a protective role against NT-induced oxidative stress as well as the reproductive effects by improving the oxidative status, semen quality and the testicular histological damage.

TL;DR: The result of this study suggests the nephroprotective potential of nobiletin which may be related to its anti-oxidant, anti-apoptotic and anti-inflammatory effects.

TL;DR: Resveratrol makes a positive contribution to fertility by exhibiting anti-apoptotic and antiperoxidative effects against DOX-induced testicular damage.

TL;DR: Results showed increase of the oxidative damage leads cells to the apoptosis, therefore reduced cell viability, and this study focuses on acute cytotoxicity of reactive oxygen species and DNA damaging effects of mentioned nanoparticles.

TL;DR: It is demonstrated that tunica vaginalis mesotheliomas are strain specific and not likely of genotoxic origin and less likelihood of human cancer risk than previously estimated.

TL;DR: Findings suggest that nicotine-induced migration and invasion may occur in a mechanism through activation of α5-nAChR, which can contribute to metastasis or development of human lung cancer.

TL;DR: According to this investigation, carbaryl caused histopathologic damages in liver and kidney tissues of B. variabilis.

TL;DR: It is clear that long term exposure to Cd and Pb contamination causes toxic effect in the liver and black, red, and white tea exerted a varied impact on the histological structure and innervation of the small intestine wall as well as on the absorptive function of small intestine mucosa in rats poisoned with Pb and Cd than green tea.

TL;DR: In cultures exposed to charcoal filtered cigarette smoke, little changes in cilia length were seen after four exposure repetitions, but those effects were reversed after a two day recovery period, indicating that volatile organic compounds, being removed by the charcoal filter tip, affect primary bronchiolar epithelial cells concerning their cilia formation and function comparable with the in vivo situation.

TL;DR: It is found that concomitant administration of erythropoietin significantly reversed the cisplatin induced nitro-oxidative stress - with significant increases in sciatic nerve glutathione and superoxide dismutase antioxidant enzyme levels and a significant decrease in iNOS gene expression.

TL;DR: The combination of exposure to smoke and bacterial compounds resulted in a mouse model that resembles several aspects of human disease and the quantity of the exposure with microorganisms has a strong effect on the phenotype.

TL;DR: The synergistic effect of Se and Vit E is most powerful in reducing the toxicity induced by SA and improving the humoral immune response of mice.

TL;DR: The present study demonstrates the hepato-protective and reno-Protective effects of oleuropein and hydroxytyrosol olive leaves rich extracts from BPA and its derivates toxicity.

TL;DR: It is suggested that atropine has remarkable cytotoxicity to HCEP cells by inducing cell cycle arrest and death receptor-mediated mitochondrion-dependent apoptosis.

TL;DR: The results indicate that there is a dynamic participation of GFAP-expressing myofibroblasts in rat liver cirrhosis, and that they are mainly derived from hepatic stellate cells, and partly from cells in the stem cell lineage.

TL;DR: The results suggest that concentrations lower than 300 ng/ml of CsA and 16 ng/ML of FK-506 are safe for use, as they did not induce genotoxic and mutagenic damage or affect MRC-5 cell viability and proliferation.

TL;DR: Results here with NM are consistent with earlier reports that exposure to higher SM levels can cause damage to the hematopoietic system, and kidney, spleen and gastrointestinal tract toxicity, and will add to understanding of the toxic effects of topical vesicant exposure.

TL;DR: This study suggests that short-time use of 200 and 400 μg/mL iron oxide nanorods are probably safe and further studies are needed for investigation of toxic effects of different concentrations, coatings, and exposure time periods of iron oxide Nanorods.

TL;DR: A state-of-the-art automated computational method and retrospective mRNA expression analysis are shown to quantitatively study the changes of various podocyte markers in a model with selective podocyte injury, namely the rat puromycin aminonucleoside (PAN) nephropathy model.

TL;DR: The time-dependent progression into a life-threatening pulmonary edema can effectively be suppressed by protective, low-pressure PEEP when implemented early enough after exposure to phosgene.

TL;DR: It is demonstrated that rebamipide suppresses N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis and may also inhibit progression of cancer in rats.

TL;DR: It is concluded that baclofen produce beneficial effect against MPTP induced PD like symptoms rats through GABAergic mechanism and reversed the protective effect of bacl ofen GABA-B receptor play role in the neuroprotection.

TL;DR: It is suggested that permethrin caused degenerative effects on ovarian morphology in a dose dependent manner when compared with the control group.

TL;DR: The data suggest that the greater bioavailability of metals could be involved in JNK activation and, consequently, in the reduction of fiber coherence and increase in the viscoelasticity and cytotoxicity of BEAS cells.

TL;DR: Both TPM and GVP fractions strongly enhanced the gene expression of HMOX1, which is encoding the limiting enzyme in heme degradation and a key regulator of oxidative stress and inflammatory process, and charcoal is a useful material for reducing the biological effects of GVP.

TL;DR: The administration of nandrolone decanoate at high doses more effective on lipid peroxidation, antioxidant enzyme activities, sperm abnormality, histopathology, apoptotic and DNA changes compared to low dose group and to control group.