Showing papers in "Journal of Inorganic Biochemistry in 1993"

TL;DR: Magnesium inhibits the crystallization of hydroxyapatite through a reduction of Ca/P molar ratio and crystal sizes of apatite as discussed by the authors and the reduction of the crystal sizes is also very great for very low magnesium content and increases on increasing magnesium concentration in solution up to 35 Mg atom percent with respect to the total metal ions.

TL;DR: The results of this investigation prove that the chemical properties of Cr nic and Cr pic complexes differ markedly, which result in a vast difference in the biological action of the complexes.

TL;DR: All monomeric cyclometallated palladium complexes found to be cytotoxic (IC50) at micrograms/ml concentrations, while two complexes also displayed some differential cytotoxicity.

TL;DR: Novel coordination-induced features have been observed in circular dichroism spectra in metal binding sites of Mg(H2O)6(2+) with RNA.

TL;DR: The protonation constants of the tripeptide glycylglycyl-L-histidine (L-) have been determined and displacement occurs by a proton-assisted nucleophilic pathway with rate-determining cleavage of the first nickel(II)-N( peptide) bond.

TL;DR: The molecular structures and electronic spectra of a series of four-, five-, and six-coordinate complexes of cobalt, nickel, copper, and zinc, stabilized by tris(pyrazolyl)hydroborato ligands, have been determined as discussed by the authors.

TL;DR: In this paper, a new model compound of CuZn-SOD (Cu(II)Zn(II)-superoxide dismutase) was synthesized and studied.

TL;DR: Determinations by electrophoresis in agarose gels of the mobility of the DNA in drug:DNA complexes indicated that only the Pd(II)-putrescine compounds have the ability to induce significant conformational changes in the covalently closed circular (ccc) form of the pUC8 plasmid DNA.

TL;DR: A simulation approach, based on the knowledge of the stability constants of the different complex species existing in experimental conditions, has allowed us to obtain the correct speciation and to use these data to calculate the pertinent catalytic constants.

TL;DR: In this paper, the interaction of divalent metal ions Cd, Hg, and Pb with the light harvesting proteins (LHC-II) of chloroplast thylakoid membranes was investigated in aqueous solution with metal ion concentrations of 0.01 to 20 mM, using Fourier Transform infrared (FTIR) difference spectroscopy.

TL;DR: The pentapeptide fragment of ANF, Asn-Ser-Phe-Arg-Tyr-NH2, coordinates to Cu(II) using the same four nitrogen donor centers as simple pentapePTides such as pentaalanine yet the complexes are of much higher stability as a result of a highly organized side-chain structure which is present in the complex but absent from the free ligand.

TL;DR: The alicyclic ammine/amine Pt(II) complexes, where R is C3-C6 were selected as representative of the class to undergo antitumor evaluations demonstrating cytotoxicity superior to that of the clinically established cisplatin.

TL;DR: The synthesis of eight new mixed-ligand complexes of Cu(II) of the type [Cu(NN)(Antb)]X is reported in this paper, where Antb is the anion of cinoxacin (Cnx) or oxolinic acid (Oxo), both drugs of the quinolone family.

TL;DR: The crystal structure of the Zn(sulfathiazole) 2 ·H 2 O complex is reported in this paper, which is a monoclinic space group C 2/c with cell dimensions are a = 9.61(1) A, β = 99.44(6)°, V = 2343(2) A 3, Z = 4, and D x = 1.68 g/cm 3.

TL;DR: Four new palladium( II) and platinum(II) complexes of formula [M(dipy)(AA)]+ have been synthesized and characterized with amino acids binding as bidentate ligands and the mode of binding between these complexes and DNA seems to be noncovalent.

TL;DR: These compounds had good to excellent antitumor activity against murine leukemia L1210 cells and those possessing both axial trifluoroacetate groups and monodentate bis-carboxylate ligands in the equatorial positions were the most active in the series investigated.

TL;DR: In this paper, the reactions of trichloro(diethylenetriamine)platinum(IV) chloride, mer -[Pt(dien)Cl 3 )Cl, with a nucleobase, 9-methylhypoxanthine, mHyp, and a nucleotide, 5′-guanosine monophosphate, 5-GMP, were studied to model those of platinum(IV)-antumor agents with nucleic acids.

TL;DR: The results indicate that free radical generation from the reaction of nickel(II)-thiol complexes and molecular oxygen, and/or lipid hydroperoxides, may play an important role in the mechanism(s) of Ni(II) toxicity and carcinogenesis.

TL;DR: A 134-kDa complex of PSP and membrane receptor, identified by gel-filtration chromatography of cross-linked samples from binding assays, provides evidence for a membrane receptor for PSP in rat tissues.

TL;DR: The existence of a metallothionein-like protein in erythrocytes which binds lead, sequestering it into a nonbioavailable form and hence protects against lead toxicity is suggested.

TL;DR: In this article, the structure of bis-isoorotato-diaquazinc(II) was solved by means of the heavy atom method from the zinc special position.

TL;DR: The mineral concretions were found to be nano-crystalline carbonate-hydroxyapatite with a mean Ca/P molar ratio equal to 1.65, very close to the theoretical value of 1.67.

TL;DR: The copper(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.

TL;DR: Frozen solution 57Fe Mössbauer spectra of the Fe(II) Fur indicated the presence of Fe( II) in a high spin distorted octahedral environment and the role of the metal ion as co-repressor in the binding of Fur to DNA is discussed.

TL;DR: The preferential inhibition of Eco RI activity is unprecedented for any platinum species reported to date and the in vivo and in vitro anticancer properties of some of the platinum complexes are described.

TL;DR: Kinetic studies indicate that Mg2+ binds to the polynucleotide mainly (or solely) as a mobile cloud (electrostatically, outer-sphere), whereas the transition metal ions undergo site binding (inner-spheres coordination) with poly(dG-dC).

TL;DR: The interaction of ruthenium(III) with human serum transferrin has been investigated through UV/visible and CD spectroscopy and the chemical properties of the obtained rUThenium/transferrin complex are described.

TL;DR: Effect of Glucose Tolerance Factor extracted from commercially available yeast extract powder was examined on streptozotocin diabetic rats, indicating an anti-diabetic potential of GTF.

TL;DR: Complex formation between oxovanadium(IV) and glutathione was investigated in aqueous solution by EPR and electron absorption spectroscopy to identify the complexed species that were reported to form upon reduction of exogenous vanadium(V) in cellular systems.