Showing papers in "Nanophotonics in 2014"

Silicon-based on-chip multiplexing technologies and devices for Peta-bit optical interconnects

Abstract: Abstract An effective solution to enhance the capacity of an optical-interconnect link is utilizing advanced multiplexing technologies, like wavelength-division-multiplexing (WDM), polarization-division multiplexing (PDM), spatial-division multiplexing (SDM), bi-directional multiplexing, etc. On-chip (de)multiplexers are necessary as key components for realizing these multiplexing systems and they are desired to have small footprints due to the limited physical space for on-chip optical interconnects. As silicon photonics has provided a very attractive platform to build ultrasmall photonic integrated devices with CMOS-compatible processes, in this paper we focus on the discussion of silicon-based (de)multiplexers, including WDM filters, PDM devices, and SDM devices. The demand of devices to realize a hybrid multiplexing technology (combining WDM, PDM and SDM) as well as a bidirectional multiplexing technologies are also discussed to achieve Peta-bit optical interconnects.

Nonlinear Group IV photonics based on silicon and germanium: from near-infrared to mid-infrared

Abstract: Abstract Group IV photonics hold great potential for nonlinear applications in the near- and mid-infrared (IR) wavelength ranges, exhibiting strong nonlinearities in bulk materials, high index contrast, CMOS compatibility, and cost-effectiveness. In this paper, we review our recent numerical work on various types of silicon and germanium waveguides for octave-spanning ultrafast nonlinear applications. We discuss the material properties of silicon, silicon nitride, silicon nano-crystals, silica, germanium, and chalcogenide glasses including arsenic sulfide and arsenic selenide to use them for waveguide core, cladding and slot layer. The waveguides are analyzed and improved for four spectrum ranges from visible, near-IR to mid-IR, with material dispersion given by Sellmeier equations and wavelength-dependent nonlinear Kerr index taken into account. Broadband dispersion engineering is emphasized as a critical approach to achieving on-chip octave-spanning nonlinear functions. These include octave-wide supercontinuum generation, ultrashort pulse compression to sub-cycle level, and mode-locked Kerr frequency comb generation based on few-cycle cavity solitons, which are potentially useful for next-generation optical communications, signal processing, imaging and sensing applications.

Silicon photonic devices and integrated circuits

Abstract: Silicon photonic devices and integrated circuits have undergone rapid and significant progresses during the last decade, transitioning from research topics in universities to product development in corporations. Silicon photonics is anticipated to be a disruptive optical technology for data communications, with applications such as intra-chip interconnects, short-reach communications in datacenters and supercomputers, and long-haul optical transmissions. Bell Labs, as the research organization of Alcatel-Lucent, a network system vendor, has an optimal position to identify the full potential of silicon photonics both in the applications and in its technical merits. Additionally it has demonstrated novel and improved high-performance optical devices, and implemented multi-function photonic integrated circuits to fulfill various communication applications. In this paper, we review our silicon photonic programs and main achievements during recent years. For devices, we review highperformance single-drive push-pull silicon Mach-Zehnder modulators, hybrid silicon/III-V lasers and silicon nitrideassisted polarization rotators. For photonic circuits, we review silicon/silicon nitride integration platforms to implement wavelength-division multiplexing receivers and transmitters. In addition, we show silicon photonic circuits are well suited for dual-polarization optical coherent transmitters and receivers, geared for advanced modulation formats. We also discuss various applications in the field of communication which may benefit from implementation in silicon photonics.

Resolving the thermal challenges for silicon microring resonator devices

Abstract: Silicon microring resonators have been hailed for their potential use in next-generation optical inter- connects. However, the functionality of silicon microring based devices suffer from susceptibility to thermal fluc- tuations that is often overlooked in their demonstrated results, but must be resolved for their future implemen- tation in microelectronic applications. We survey the emerging efforts that have been put forth to resolve these thermal susceptibilities and provide a comprehensive discussion of their advantages and disadvantages.

Recent breakthroughs in carrier depletion based silicon optical modulators

Abstract: The majority of the most successful optical modulators in silicon demonstrated in recent years operate via the plasma dispersion effect and are more specifically based upon free carrier depletion in a silicon rib waveguide. In this work we overview the different types of free carrier depletion type optical modulators in silicon. A summary of some recent example devices for each configuration is then presented together with the performance that they have achieved. Finally an insight into some current research trends involving silicon based optical modulators is provided including integration, operation in the mid-infrared wavelength range and application in short and long haul data transmission links

Plasmonic near-field transducer for heat-assisted magnetic recording

Abstract: Plasmonic devices, made of apertures or anten- nas, have played significant roles in advancing the fields of optics and opto-electronics by offering subwavelength manipulation of light in the visible and near infrared fre- quencies. The development of heat-assisted magnetic recording (HAMR) opens up a new application of plasmonic nanostructures, where they act as near field transducers (NFTs) to locally and temporally heat a sub-diffraction- limited region in the recording medium above its Curie temperature to reduce the magnetic coercivity. This allows use of very small grain volume in the medium while still maintaining data thermal stability, and increasing storage density in the next generation hard disk drives (HDDs). In this paper, we review different plasmonic NFT designs that are promising to be applied in HAMR. We focus on the mechanisms contributing to the coupling and confine- ment of optical energy. We also illustrate the self-heating issue in NFT materials associated with the generation of a confined optical spot, which could result in degradation of performance and failure of components. The possibility of using alternative plasmonic materials will be discussed.

SERS-based detection of biomolecules

Abstract: In order to detect biomolecules, different approaches using for instance biological, spectroscopic or imaging techniques are established. Due to the broad variety of these methods, this review is focused on surface enhanced Raman spectroscopy (SERS) as an analytical tool in biomolecule detection. Here, the molecular speci- ficity of Raman spectroscopy is combined with metallic nanoparticles as sensor platform, which enhances the sig- nal intensity by several orders of magnitude. Within this article, the characterization of diverse biomolecules by means of SERS is explained and moreover current applica- tion fields are presented. The SERS intensity and as a con- sequence thereof the reliable detection of the biomolecule of interest is effected by distance, orientation and affinity of the molecule towards the metal surface. Furthermore, the great capability of the SERS technique for cutting-edge applications like pathogen detection and cancer diagnosis is highlighted. We wish to motivate by this comprehensive and critical summary researchers from various scientific background to create their own ideas and schemes for a SERS-based detection and analysis of biomolecules.

Plasmonic gas and chemical sensing

Abstract: Sensitive and robust detection of gases and chemical reactions constitutes a cornerstone of scientific research and industrial applications. In an effort to reach progressively smaller reagent concentrations and sensing volumes, optical sensor technology has experienced a paradigm shift from extended thin-film systems towards engineered nanoscale devices. In this size regime, plasmonic particles and nanostructures provide an ideal toolkit for the realization of novel sensing concepts. This is due to their unique ability to simultaneously focus light into subwavelength hotspots of the electromagnetic field and to transmit minute changes of the local environment back into the farfield as a modulation of their optical response. Since the basic building blocks of a plasmonic system are commonly noble metal nanoparticles or nanostructures, plasmonics can easily be integrated with a plethora of chemically or catalytically active materials and compounds to detect processes ranging from hydrogen absorption in palladium to the detection of trinitrotoluene (TNT). In this review, we will discuss a multitude of plasmonic sensing strategies, spanning the technological scale from simple plasmonic particles embedded in extended films to highly engineered complex plasmonic nanostructures. Due to their flexibility and excellent sensing performance, plasmonic structures may open an exciting pathway towards the detection of chemical and catalytic events down to the single molecule level.

Modeling light-sound interaction in nanoscale cavities and waveguides

Abstract: The interaction of light and sound waves at the micro and nanoscale has attracted considerable interest in recent years. The main reason is that this interaction is responsible for a wide variety of intriguing physical phenomena, ranging from the laser-induced cooling of a micromechanical resonator down to its ground state to the management of the speed of guided light pulses by exciting sound waves. A common feature of all these phenomena is the feasibility to tightly confine photons and phonons of similar wavelengths in a very small volume. Amongst the different structures that enable such confinement, optomechanical or phoxonic crystals, which are periodic structures displaying forbidden frequency band gaps for light and sound waves, have revealed themselves as the most appropriate candidates to host nanoscale structures where the light-sound interaction can be boosted. In this review, we describe the theoretical tools that allow the modeling of the interaction between photons and acous- tic phonons in nanoscale structures, namely cavities and waveguides, with special emphasis in phoxonic crystal structures. First, we start by summarizing the different optomechanical or phoxonic crystal structures proposed so far and discuss their main advantages and limita- tions. Then, we describe the different mechanisms that make light interact with sound, and show how to treat them from a theoretical point of view. We then illustrate the different photon-phonon interaction processes with numerical simulations in realistic phoxonic cavities and waveguides. Finally, we introduce some possible applica- tions which can take enormous benefit from the enhanced interaction between light and sound at the nanoscale.

Engineering light-matter interaction for emerging optical manipulation applications

Abstract: In this review, we explore recent trends in opti- cal micromanipulation by engineering light-matter inter- action and controlling the mechanical effects of optical fields. One central theme is exploring the rich phenom- ena beyond the now established precision measurements based on trapping micro beads with tightly focused beams. Novel synthesized beams, exploiting the linear and angular momentum of light, open new possibilities in optical trapping and micromanipulation. Similarly, novel structures are promising to enable new optical micro- manipulation modalities. Moreover, an overview of the amazing features of the optics of tractor beams and back- ward-directed energy fluxes will be presented. Recently the so-called effect of negative propagation of the beams (existence of the backward energy fluxes) has been con- firmed for X-waves and Airy beams. In the review, we will also discuss the negative pulling force of structured beams and negative energy fluxes in the vicinity of fibers. The effect is achieved due to the interaction of multipoles or, in another interpretation, the momentum conservation. Both backward-directed Poynting vector and backward optical forces are counter-intuitive and give an insight into new physics and technologies. Exploiting the degrees of freedom in synthesizing novel beams and designed micro- structures offer attractive prospects for emerging optical manipulation applications.

Trapping of resonant metallic nanoparticles with engineered vectorial optical field

Abstract: Abstract Optical trapping and manipulation using focused laser beams has emerged as a powerful tool in the biological and physical sciences. However, scaling this technique to metallic nanoparticles remains challenging due to the strong scattering force and optical heating effect. In this work, we propose a novel strategy to optically trap metallic nanoparticles even under the resonant condition using engineered optical field. The distribution of the optical forces can be tailored through optimizing the spatial distribution of a vectorial optical illumination to favour the stable trapping of a variety of metallic nanoparticles under various conditions. It is shown that this optical tweezers has the ability of generating negative scattering force and supporting stable three-dimensional trapping for gold nanoparticles at resonance while avoiding trap destabilization due to optical overheating. The technique presented in this work offers a versatile solution for trapping metallic nanoparticles and may open up new avenues for optical manipulation.

A “plasmonic cuvette”: dye chemistry coupled to plasmonic interferometry for glucose sensing

Abstract: Abstract A non-invasive method for the detection of glucose is sought by millions of diabetic patients to improve personal management of blood glucose over a lifetime. In this work, the synergistic advantage of combining plasmonic interferometry with an enzyme-driven dye assay yields an optical sensor capable of detecting glucose in saliva with high sensitivity and selectivity. The sensor, coined a “plasmonic cuvette,” is built around a nano-scale groove-slit-groove (GSG) plasmonic interferometer coupled to an Amplex–red/Glucose–oxidase/Glucose (AR/GOx/Glucose) assay. The proposed device is highly sensitive, with a measured intensity change of 1.7×105%/m (i.e., one order of magnitude more sensitive than without assay) and highly specific for glucose sensing in picoliter volumes, across the physiological range of glucose concentrations found in human saliva (20–240 μm). Real-time glucose monitoring in saliva is achieved by performing a detailed study of the underlying enzyme-driven reactions to determine and tune the effective rate constants in order to reduce the overall assay reaction time to ∼2 min. The results reported suggest that by opportunely choosing the appropriate dye chemistry, a plasmonic cuvette can be turned into a general, real-time sensing scheme for detection of any molecular target, with high sensitivity and selectivity, within extremely low volumes of biological fluid (down to femtoliters). Hereby, we present the results on glucose detection in artificial saliva as a notable and clinically relevant case study.

Progress in silicon platforms for integrated optics

Abstract: Abstract Rapid progress has been made in recent years repurposing CMOS fabrication tools to build complex photonic circuits. As the field of silicon photonics becomes more mature, foundry processes will be an essential piece of the ecosystem for eliminating process risk and allowing the community to focus on adding value through clever design. Multi-project wafer runs are a useful tool to promote further development by providing inexpensive, low-risk prototyping opportunities to academic and commercial researchers. Compared to dedicated silicon manufacturing runs, multi-project-wafer runs offer cost reductions of 100× or more. Through OpSIS, we have begun to offer validated device libraries that allow designers to focus on building systems rather than modifying device geometries. The EDA tools that will enable rapid design of such complex systems are under intense development. Progress is also being made in developing practical optical and electronic packaging solutions for the photonic chips, in ways that eliminate or sharply reduce development costs for the user community. This paper will provide a review of the recent developments in silicon photonic foundry offerings with a focus on OpSIS, a multi-project-wafer foundry service offering a silicon photonics platform, including a variety of passive components as well as high-speed modulators and photodetectors, through the Institute of Microelectronics in Singapore.

Tip enhanced Raman scattering: plasmonic enhancements for nanoscale chemical analysis

Abstract: Abstract Tip enhanced Raman scattering (TERS) is an emerging technique that uses a metalized scanning probe microscope tip to spatially localize electric fields that enhances Raman scattering enabling chemical imaging on nanometer dimensions. Arising from the same principles as surface enhanced Raman scattering (SERS), TERS offers unique advantages associated with controling the size, shape, and location of the enhancing nanostructure. In this article we discuss the correlations between current understanding of SERS and how this relates to TERS, as well as how TERS provides new understanding and insights. The relationship between plasmon resonances and Raman enhancements is emphasized as the key to obtaining optimal TERS results. Applications of TERS, including chemical analysis of carbon nanotubes, organic molecules, inorganic crystals, nucleic acids, proteins, cells and organisms, are used to illustrate the information that can be gained. Under ideal conditions TERS is capable of single molecule sensitivity and sub-nanometer spatial resolution. The ability to control plasmonic enhancements for chemical analysis suggests new experiments and opportunities to understand molecular composition and interactions on the nanoscale.

Silicon photonic devices for mid-infrared applications

Abstract: The mid-infrared (IR) wavelength region (2-20 µm) is of great interest for a number of applications, including trace gas sensing, thermal imaging, and free- space communications. Recently, there has been signifi- cant progress in developing a mid-IR photonics platform in Si, which is highly transparent in the mid-IR, due to the ease of fabrication and CMOS compatibility provided by the Si platform. Here, we discuss our group's recent contributions to the field of silicon-based mid-IR photon- ics, including photonic crystal cavities in a Si membrane platform and grating-coupled high-quality factor ring resonators in a silicon-on-sapphire (SOS) platform. Since experimental characterization of microphotonic devices is especially challenging at the mid-IR, we also review our mid-IR characterization techniques in some detail. Addi- tionally, pre- and post-processing techniques for improv- ing device performance, such as resist reflow, Piranha clean/HF dip cycling, and annealing are discussed.

Enhanced Raman scattering in graphene by plasmonic resonant Stokes emission

Abstract: Abstract Exploiting surface plasmon polaritons to enhance interactions between graphene and light has recently attracted much interest. In particular, nonlinear optical processes in graphene can be dramatically enhanced and controlled by plasmonic nanostructures. This work demonstrates Raman scattering enhancement in graphene based on plasmonic resonant enhancement of the Stokes emission, and compares this mechanism with the conventional Raman enhancement by resonant pump absorption. Arrays of optical nanoantennas with different resonant frequency are utilized to independently identify the effects of each mechanism on Raman scattering in graphene via the measured enhancement factor and its spectral linewidth. We demonstrate that, while both mechanisms offer large enhancement factors (scattering cross-section gains of 160 and 20 for individual nanoantennas, respectively), they affect the graphene Raman spectrum quite differently. Our results provide a benchmark to assess and quantify the role and merit of each mechanism in surface-plasmon-mediated Raman scattering in graphene, and may be employed for design and realization of a variety of graphene optoelectronic devices involving nonlinear optical processes.

Optical torque from enhanced scattering by multipolar plasmonic resonance

Abstract: We present a theoretical study of the optical angu- lar momentum transfer from a circularly polarized plane wave to thin metal nanoparticles of different rotational sym- metries. While absorption has been regarded as the predomi- nant mechanism of torque generation on the nanoscale, we demonstrate numerically how the contribution from scat- tering can be enhanced by using multipolar plasmon reso- nance. The multipolar modes in non-circular particles can convert the angular momentum carried by the scattered field and thereby produce scattering-dominant optical torque, while a circularly symmetric particle cannot. Our results show that the optical torque induced by resonant scattering can contribute to 80% of the total optical torque in gold parti- cles. This scattering-dominant torque generation is extremely mode-specific, and deserves to be distinguished from the absorption-dominant mechanism. Our findings might have applications in optical manipulation on the nanoscale as well as new designs in plasmonics and metamaterials.

Optical and electrical mappings of surface plasmon cavity modes

Abstract: Abstract Plasmonics is a rapidly expanding field, founded in physics but now with a growing number of applications in biology (biosensing), nanophotonics, photovoltaics, optical engineering and advanced information technology. Appearing as charge density oscillations along a metal surface, excited by electromagnetic radiation (e.g., light), plasmons can propagate as surface plasmon polaritons, or can be confined as standing waves along an appropriately-prepared surface. Here, we review the latter manifestation, both their origins and the manners in which they are detected, the latter dominated by near field scanning optical microscopy (NSOM/SNOM). We include discussion of the “plasmonic halo” effect recently observed by the authors, wherein cavity-confined plasmons are able to modulate optical transmission through step-gap nanostructures, yielding a novel form of color (wavelength) selection.

Integrating electron and near-field optics: dual vision for the nanoworld

Abstract: The integration of near-field scanning opti- cal microscopy (NSOM) with the imaging and localized excitation capabilities of electrons in a scanning electron microscope (SEM) offers new capabilities for the observa- tion of highly resolved transport phenomena in the areas of electronic and optical materials characterization, semi- conductor nanodevices, plasmonics and integrated nano- photonics. While combined capabilities for atomic force microscopy (AFM) and SEM are of obvious interest to pro- vide localized surface topography in concert with the ease and large spatial dynamic range of SEM and dual beam imaging (e.g., in-situ AFM following focused ion beam modification), integration with near-field optical imaging capability can also provide access to localized transport phenomena beyond the reach of far-field systems. In par- ticular, the flexibility that is achieved with the capability for independent, high resolution placement of an electron source, providing localized excitation in the form of free carriers, photons or plasmons, with scanning of the opti- cal collecting tip allows for unique types of "dual-probe" experiments that directly image energy transfer. We review integrated near-field and electron optics systems to date, highlight applications in a variety of fields and suggest future directions.

Energy-saving quality road lighting with colloidal quantum dot nanophosphors

Abstract: Here the first photometric study of road-lighting white light-emitting diodes (WLEDs) integrated with semi- conductor colloidal quantum dots (QDs) is reported ena- bling higher luminance than conventional light sources, specifically in mesopic vision regimes essential to street lighting. Investigating over 100 million designs uncovers that quality road-lighting QD-WLEDs, with a color qual- ity scale and color rendering index ≥ 85, enables 13-35% higher mesopic luminance than the sources commonly used in street lighting. Furthermore, these QD-WLEDs were shown to be electrically more efficient than conventional sources with power conversion efficiencies ≥ 16-29%. Considering this fact, an experimental proof-of-concept QD-WLED was demonstrated, which is the first account of QD based color conversion custom designed for street lighting applications. The obtained white LED achieved the targeted mesopic luminance levels in accordance with the road lighting standards of the USA and the UK. These results indicate that road-lighting QD-WLEDs are strongly promising for energy-saving quality road lighting.

Nonlinear spectroscopy in the near-field: time resolved spectroscopy and subwavelength resolution non-invasive imaging

Abstract: Abstract The combination of near-field microscopy along with nonlinear optical spectroscopic techniques is presented here. The scanning near-field imaging technique can be integrated with nonlinear spectroscopic techniques to improve spatial and axial resolution of the images. Additionally, ultrafast dynamics can be probed down to nano-scale dimension. The review shows some examples for this combination, which resulted in an exciton map and vibrational contrast images with sub-wavelength resolution. Results of two-color femtosecond time-resolved pump-probe experiments using scanning near-field optical microscopy (SNOM) on thin films of the organic semiconductor 3,4,9,10 Perylenetetracarboxylic dianhydride (PTCDA) are presented. While nonlinear Raman techniques have been used to obtain highly resolved images in combination with near-field microscopy, the use of femtosecond laser pulses in electronic resonance still constitutes a big challenge. Here, we present our first results on coherent anti-Stokes Raman scattering (fs-CARS) with femtosecond laser pulses detected in the near-field using SNOM. We demonstrate that highly spatially resolved images can be obtained from poly(3-hexylthiophene) (P3HT) nano-structures where the fs-CARS process was in resonance with the P3HT absorption and with characteristic P3HT vibrational modes without destruction of the samples. Sub-diffraction limited lateral resolution is achieved. Especially the height resolution clearly surpasses that obtained with standard microCARS. These results will be the basis for future investigations of mode-selective dynamics in the near-field.

Optically induced forces in scanning probe microscopy

Abstract: Abstract Typical measurements of light in the near-field utilize a photodetector such as a photomultiplier tube or a photodiode, which is placed remotely from the region under test. This kind of detection has many draw-backs including the necessity to detect light in the far-field, the influence of background propagating radiation, the relatively narrowband operation of photodetectors which complicates the operation over a wide wavelength range, and the difficulty in detecting radiation in the far-IR and THz. Here we review an alternative near-field light measurement technique based on the detection of optically induced forces acting on the scanning probe. This type of detection overcomes some of the above limitations, permitting true broad-band detection of light directly in the near-field with a single detector. The physical origins and the main characteristics of optical force detection are reviewed. In addition, intrinsic effects of the inherent optical forces for certain operation modalities of scanning probe microscopy are discussed. Finally, we review practical applications of optical force detection of interest for the broader field of the scanning probe microscopy.

Photoconductive NSOM for mapping optoelectronic phases in nanostructures

Abstract: Abstract The advent of optically functional materials with low-intensive processing methods is accompanied by a growing need for high resolution imaging to probe the inherent inhomogeneities in the underlying microstructure. Atomic force microscopy based techniques are typically utilized for imaging the surface of organic thin films, quantum dots and other nanomaterials with ultrahigh resolution. Several modes like conductive, Kelvin, electrostatic amongst others have been particularly successful in imaging the local current, potential and charge distribution of variety of systems. However, the functionality of photoconduction in these materials cannot be directly imaged by these modes alone. There is a requirement for a local excitation source or collection arrangement that is compatible with scanning microscopy techniques followed by a current monitoring mechanism. Near-field scanning optical microscopy (NSOM) possesses all the advantages of scanning microscopy and is capable of local excitation that overcomes the diffraction limit faced by conventional optical microscopes. Additionally, NSOM can be carried out on actual photoconductive two terminal and three terminal device structures to image local optoelectronic properties. In this review, we present the various geometries that have been demonstrated to perform photoconductive NSOM (p-NSOM). We highlight a representative set of important results and discuss the implications of photocurrent imaging in macroscopic device performance.

The optical near-field: super-resolution imaging with structural and phase correlation

Abstract: Abstract An overview of near-field optics is presented with a focus on the fundamental advances that have been made in the field since its inception 30 years ago. A focus is placed on the advancements that have been achieved in instrumentation. These advances have led to a greater generality of use with ultra-low mechanical and optical noise and the ultimate in force sensitivity with near-field optical probes. An emphasis is placed on the importance of fully integrating near-field optics with other imaging and spectroscopic modalities including Raman spectroscopy and electron/ion beam imaging. Important directions in probe design, force feedback methods and scanner flexibility are described. These developing avenues provide considerable optimism for an ever increasing incorporation of near-field optics to help resolve critical problems in fundamental and applied science.

Multiprobe NSOM fluorescence

Abstract: Abstract In this paper, we demonstrate simultaneous AFM/NSOM using a dual-tip normal tuning-fork based scanning probe microscope. By scanning two SPM probes simultaneously, one dedicated for AFM with a standard tip diameter of 20 nm, and the second having a 150 nm aperture NSOM fiber with 200 nm thick gold coating, we combine the benefits of ∼20 nm spatial resolution from the AFM tip with the spectral information of a near-field optical probe. The combination of simultaneous dual-tip scanning enables us to decouple the requirements for high resolution topography and probe functionality. Our method represents a marked shift from previous applications of multi-probe SPM where essentially a pump-probe methodology is implemented in which one tip scans the area around the second. As a model system, we apply dual-tip AFM/NSOM scanning to a sample of spin-cast nano-clustered Lumogen dyes, which show remarkable brightness and photochemical stability. We observe morphology features with a resolution of 20 nm, and a near-field optical resolution of 150 nm, validating our approach.

Nanophotonics of protein amyloids

Abstract: Abstract Technological breakthroughs in the super-resolution optical imaging techniques have enriched our current understanding of a range of biological systems and biomolecular processes at the nanoscopic spatial resolution. Protein amyloids are an important class of ordered protein assemblies consisting of misfolded proteins that are implicated in a wide range of devastating human diseases. In order to decipher the structural basis of the supramolecular protein assembly in amyloids and their detrimental interactions with the cell membranes, it is important to employ high-resolution optical imaging techniques. Additionally, amyloids could serve as novel biological nanomaterials for a variety of potential applications. In this review, we summarize a few examples of the utility of near-field scanning optical imaging methodologies to obtain a wealth of structural information into the nanoscale amyloid assembly. Although the near-field technologies were developed several decades ago, it is only recently that these methodologies are being applied and adapted for amyloid research to yield novel information pertaining to the exciting nanoscopic world of protein aggregates. We believe that the account on the nanophotonics of amyloids described in this review will be useful for the future studies on the biophysics of amyloids.