36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
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This article is published in Nucleic Acids Research.The article was published on 1991-07-25 and is currently open access. It has received 430 citations till now. The article focuses on the topics: Phosphoprotein & Complementary DNA.read more
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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
TL;DR: The results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism.
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AdipoQ is a novel adipose-specific gene dysregulated in obesity.
TL;DR: The tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue.
Journal ArticleDOI
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
Peter Tontonoz,Laszlo Nagy,Laszlo Nagy,Jacqueline G.A Alvarez,Vilmos A. Thomazy,Ronald M. Evans,Ronald M. Evans +6 more
TL;DR: It is demonstrated that the nuclear receptor PPARγ is induced in human monocytes following exposure to oxLDL and is expressed at high levels in the foam cells of atherosclerotic lesions, and it is suggested that endogenous PParγ ligands may be important regulators of gene expression during atherogenesis.
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Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
TL;DR: Targeting GLUT12 could provide novel methods for detection and treatment of breast and prostate cancer and help clarify the role of glucose transporter expression in breast cancer.
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Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
TL;DR: Data suggest that VEGF/VPF expression in the retina plays a central role in the development of retinal ischemia-induced ocular neovascularization.
References
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
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Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.
TL;DR: cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors.
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Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.
B E Rich,Joan A. Steitz +1 more
TL;DR: The synthetic P0, P1, and P2 proteins were serologically and electrophoretically identical to P-proteins extracted from HeLa cells and were incorporated into 60S but not 40S ribosomes and also assembled into a complex similar to that described for E. coli L7/L12 and L10.