3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
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TLDR
This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.Abstract:
Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. The 3D printing has become one of the most revolutionary and powerful tool serving as a technology of precise manufacturing of individually developed dosage forms, tissue engineering and disease modeling. The current achievements include multifunctional drug delivery systems with accelerated release characteristic, adjustable and personalized dosage forms, implants and phantoms corresponding to specific patient anatomy as well as cell-based materials for regenerative medicine. This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015. Currently developed techniques of 3D printing are briefly described while comprehensive analysis of extrusion-based methods as the most intensively investigated is provided. The issue of printlets attributes, i.e. shape and size is described with regard to personalized dosage forms and medical devices manufacturing. The undeniable benefits of 3D printing are highlighted, however a critical view resulting from the limitations and challenges of the additive manufacturing is also included. The regulatory issue is pointed as well.read more
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Journal ArticleDOI
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials-Process Perspective.
Mohammad Azad,Deborah Olawuni,Georgia Kimbell,Abu Zayed Md Badruddoza,Md. Shahadat Hossain,Tasnim Sultana +5 more
TL;DR: This review has summarized a holistic materials–process perspective for polymers on extrusion-based 3D printing, and elaborates the discussion on the comparison of3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients.
Journal ArticleDOI
Antioxidant pla composites containing lignin for 3D printing applications: A potential material for healthcare applications
Juan Domínguez-Robles,Niamh K. Martin,Mun Leon Fong,Sarah A. Stewart,Nicola Irwin,María Isabel Rial-Hermida,Ryan F. Donnelly,Eneko Larrañeta +7 more
TL;DR: PLA/LIG were used to design meshes with different designs for wound dressing purposes and it was observed that the dimensions of the meshes affected the permeation rate of CUR, which could be modified according to the patient’s needs.
Journal ArticleDOI
3D printing: Principles and pharmaceutical applications of selective laser sintering.
Atheer Awad,Fabrizio Fina,Alvaro Goyanes,Alvaro Goyanes,Simon Gaisford,Abdul Basit,Abdul Basit +6 more
TL;DR: The current state-of-the-art in SLS 3D printing is reviewed, including the main principles underpinning this technology and the diverse selection of materials and essential parameters that influence printing are highlighted.
Journal ArticleDOI
The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality
Maisa R P Araújo,Livia L. Sa-Barreto,Tais Gratieri,Guilherme M. Gelfuso,Marcilio Cunha-Filho +4 more
TL;DR: 3D drug printing has the potential to become the biggest technological leap ever seen in the pharmaceutical segment, and according to the most optimistic prognostics, it will soon be within reach.
Journal ArticleDOI
A review of fabrication polymer scaffolds for biomedical applications using additive manufacturing techniques
Patrycja Szymczyk-Ziółkowska,Magdalena Beata Łabowska,Jerzy Detyna,Izabela Michalak,Piotr Gruber +4 more
TL;DR: In this article, the authors present the current state-of-the-art of additive manufacturing applications in the biomedical field, especially in tissue engineering, taking into account hydrogels in scaffolds fabrication.
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