Journal ArticleDOI
506: Intraamniotic interleukin-1 (IL1β) induces histologic chorioamnionitis and alters the microbiome in a primate model of inflammatory preterm birth
Kjersti Aagaard,Radhika Ganu,Jun Ma,Min Hu,Lisa A. Miller,Alan H. Jobe,Suhas G. Kallapur,Claire A. Chougnet +7 more
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This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2013-01-01. It has received 11 citations till now. The article focuses on the topics: Interleukin & Microbiome.read more
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An exposome perspective: Early-life events and immune development in a changing world.
TL;DR: The historical origins of exposome research are reviewed and a new concept is defined, the metaexposome, which considers the bidirectional effect of the environment on human subjects and the human influence on all living systems and their genomes, which is essential for human health.
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The Perinatal Microbiome and Pregnancy: Moving Beyond the Vaginal Microbiome
TL;DR: An overview on metagenomics science as a means to investigate the microbiome, observations pertaining to both variation and the presumptive potential role of a varied microbiome during pregnancy, and how future studies of the microbiome in pregnancy may lend to a better understanding of human biology, reproductive health, and parturition are provided.
Journal ArticleDOI
Spontaneous preterm birth: advances toward the discovery of genetic predisposition
Jerome F. Strauss,Roberto Romero,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez,Hannah Haymond-Thornburg,Bhavi P. Modi,Maria E. Teves,Laurel N. Pearson,Timothy P. York,Harvey A. Schenkein +9 more
TL;DR: It is proposed that whole exome sequencing, as well as whole genome sequencing, is the most promising approach for the identification of functionally significant genetic variants responsible for spontaneous preterm birth, at least in the context of pathologic inflammation.
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A Role for the Inflammasome in Spontaneous Labor at Term.
Roberto Romero,Yi Xu,Yi Xu,Olesya Plazyo,Olesya Plazyo,Piya Chaemsaithong,Piya Chaemsaithong,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Ronald Unkel,Ronald Unkel,Nandor Gabor Than,Po Jen Chiang,Zhong Dong,Zhong Dong,Zhonghui Xu,Zhonghui Xu,Adi L. Tarca,Adi L. Tarca,Vikki M. Abrahams,Sonia S. Hassan,Sonia S. Hassan,Lami Yeo,Lami Yeo,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +25 more
TL;DR: The aims of this study were to determine the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term and whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
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A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Nardhy Gomez-Lopez,Roberto Romero,Yi Xu,Yi Xu,Olesya Plazyo,Olesya Plazyo,Ronald Unkel,Ronald Unkel,Yaozhu Leng,Yaozhu Leng,Nandor Gabor Than,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Bogdan Panaitescu,Bogdan Panaitescu,Zhong Dong,Zhong Dong,Adi L. Tarca,Adi L. Tarca,Vikki M. Abrahams,Lami Yeo,Lami Yeo,Sonia S. Hassan,Sonia S. Hassan +23 more
TL;DR: Sp spontaneous preterm labor with acute histologic chorioamnionitis is characterized by an upregulation of NLRP3 and the active form of CASP-4, as well as increased ASC/CASP-1 complex formation, which may participate in the activation of CASp-1 and the maturation of IL-1β and IL-18 in the charioamniotic membranes.