7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis
TLDR
The report of a novel cytochrome P450 enzyme in mouse hippocampus (cyp7b) with close homology to cholesterol 7 alpha-hydroxylase led to determine the substrate specificity with respect to 27-hydroxycholesterol, known to be a potent inhibitor of cholesterol synthesis.About:
This article is published in Journal of Lipid Research.The article was published on 1997-05-01 and is currently open access. It has received 58 citations till now. The article focuses on the topics: Cholic acid & 27-Hydroxycholesterol.read more
Citations
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Journal ArticleDOI
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
TL;DR: The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals and causes a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults.
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Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
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Oxysterols and atherosclerosis
Andrew J. Brown,Wendy Jessup +1 more
TL;DR: There are a number of significant and quite widespread problems with current literature which preclude more than a tentative suggestion that oxysterol have a causal role in atherogenesis, and further studies are necessary to definitively determine the role of oxysterols in atherosclerosis.
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Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
TL;DR: This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.
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Regulation of bile acid synthesis
TL;DR: Recent advances in purification and cloning of these major enzymes in the pathways have led to better understanding the molecular basis of regulation of bile acid synthesis and physiological role of the alternative pathways.
References
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Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
TL;DR: The structure of the sterol 26-hydroxylase cDNA reveals it to be a mitochondrial cytochrome P-450, and blotting experiments revealed that the mRNA for this enzyme is expressed in many tissues and that it is encoded by a low copy number gene in the rabbit genome.
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Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
TL;DR: Findings suggest that SREBP-1 is responsible for basal transcription of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl CoA synthase genes in hamster liver and that S REBP-2 isresponsible for the increased transcription that follows sterol depletion with a bile acid-binding resin and a cholesterol synthesis inhibitor.
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Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.
TL;DR: Support for the role of a cytosolic oxysterol-binding protein in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) reductase was obtained by correlating the relative binding affinities of a wide range of oxysterols to their potency in suppressing HMG-CoA reduct enzyme activity in mouse fibroblast cell cultures.
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Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.
Ingemar Björkhem,Olof Andersson,Ulf Diczfalusy,Bo Sevastik,Rui-Juan Xiu,Chonggao Duan,Erik G. Lund +6 more
TL;DR: It is suggested that conversion of cholesterol into 27-hydroxycholesterol and 3 beta-hydroxylate the same methyl group three times to give a carboxylic acid represents a general defence mechanism for macrophages and possibly also other peripheral cells exposed to cholesterol.
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Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat.
TL;DR: The highest rate of cholesterogenesis in the cholesterol-fed or fasted rat is found in the gastrointestinal tract, and this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols.