Journal ArticleDOI
A chimeric VIP-PACAP analogue but not VIP pseudopeptides function as VIP receptor antagonists.
Fishbein Va,David H. Coy,Simon J. Hocart,N. Y. Jiang,John E. Mrozinski,Samuel A. Mantey,Robert T. Jensen +6 more
Reads0
Chats0
TLDR
Two different approaches used successfully with other peptides in an attempt to identify new VIP receptor antagonists are adopted, one involving the formation of pseudopeptides by insertion of reduced peptide bonds in the NH2-terminus from position 2 to 8 of VIP and the other by combining VIP(6-28) and PACAP(28-38).About:
This article is published in Peptides.The article was published on 1994-01-01. It has received 60 citations till now.read more
Citations
More filters
Journal ArticleDOI
In vitro properties of a high affinity selective antagonist of the VIP1 receptor
TL;DR: The described molecule in the first reported VIP antagonist with an affinity in the nM range and with a high selectivity for the VIP1 receptor subclass may be useful for evaluation of the physiological role of VIP in rat and human tissues.
Journal ArticleDOI
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
Mitsuteru Akahoshi,Chang Ho Song,Chang Ho Song,Adrian M. Piliponsky,Adrian M. Piliponsky,Martin Metz,Martin Metz,Andrew Guzzetta,Magnus Åbrink,Susan M. Schlenner,Susan M. Schlenner,Thorsten B. Feyerabend,Thorsten B. Feyerabend,Hans Reimer Rodewald,Gunnar Pejler,Mindy Tsai,Stephen J. Galli +16 more
TL;DR: The findings support the notion that mast cells can enhance innate defense by degradation of diverse animal toxins and that release of MCPT4, in addition to CPA3, can contribute to this mast cell function.
Journal ArticleDOI
VIP as a trophic factor in the CNS and cancer cells
TL;DR: VIP is an integrative regulator of brain growth and development during neurogenesis and embryogenesis and potentiates the ability of chemotherapeutic drugs to kill cancer cells.
Journal ArticleDOI
The role of VIP/PACAP receptor subtypes in spinal somatosensory processing in rats with an experimental peripheral mononeuropathy
TL;DR: Analysis of the expression and influence of VPAC1, VPAC2 and PAC1 receptors in rat spinal dorsal horn following a chronic constriction injury indicates that VIP/PACAP receptors may be important regulatory factors in neuropathic pain states.
Journal ArticleDOI
Development of selective agonists and antagonists for the human vasoactive intestinal polypeptide VPAC2 receptor
TL;DR: This molecule represents the first selective human VPAC(2) receptor antagonist described to date and is developed as a VIP or Ro 25-1553 analog behaving as a high affinity, VPAC (2) selective antagonist.
References
More filters
Journal ArticleDOI
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
Journal ArticleDOI
Handbook of Physiology.
TL;DR: This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
Book
Physiology of the Gastrointestinal Tract
TL;DR: Physiology of the Gastrointestinal Tract, Fifth Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.
Journal ArticleDOI
Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37).
Tsutomu Chiba,Akinori Yamaguchi,Toshiyuki Yamatani,Akira Nakamura,Tomoyuki Morishita,Tetsuya Inui,Masaaki Fukase,T. Noda,T. Fujita +8 more
TL;DR: Human calcitonin gene-related peptide fragment hCGRP-(8-37) appears to be a useful tool for determining whether the action of CGRP as well as that of CT is mediated via specific C GRP receptors or CT receptors.
PatentDOI
Vasoactive intestinal peptide
Sami I. Said,Viktor Mutt +1 more
TL;DR: In this article, biological actions including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia were isolated from intestines of animals such as a hog.