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Open AccessJournal ArticleDOI

A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol.

G R Warnick, +1 more
- 01 Jan 1978 - 
- Vol. 19, Iss: 1, pp 65-76
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TLDR
Determination of the extent of the unprecipitated apoB-associated lipoproteins by sensitive radioimmunoassay and of the amount of precipitated high density lipoprotein by radial immunodiffusion assay of apolipoproteins A-I and A-II at various heparin and Mn(2+) concentrations indicated that the usual Heparin level was adequate.
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This article is published in Journal of Lipid Research.The article was published on 1978-01-01 and is currently open access. It has received 1297 citations till now. The article focuses on the topics: High-density lipoprotein & Apolipoprotein B.

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Citations
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Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* trial)

TL;DR: In this paper, a 6-week, parallel-group, open-label, randomized, multicenter trial was conducted to compare rosuvastatin with comparators for other lipid modifications and achievement of National Cholesterol Education Program Adult Treatment Panel III and Joint European Task Force LDL cholesterol goals.
Journal ArticleDOI

Vascular risk factors and diabetic neuropathy

TL;DR: It is indicated that, apart from glycemic control, the incidence of neuropathy is associated with potentially modifiable cardiovascular risk factors, including a raised triglyceride level, body-mass index, smoking, and hypertension.
Journal ArticleDOI

Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal Women: The A TO Z Weight Loss Study: A Randomized Trial

TL;DR: In this study, premenopausal overweight and obese women assigned to follow the Atkins diet, which had the lowest carbohydrate intake, lost more weight and experienced more favorable overall metabolic effects at 12 months than women assignedto follow the Zone, Ornish, or LEARN diets.
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Menopause and Risk Factors for Coronary Heart Disease

TL;DR: It is suggested that a natural menopause has an unfavorable effect on lipid metabolism, which may contribute to an increase in the risk of coronary disease.
References
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Journal ArticleDOI

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
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Plasma-high-density-lipoprotein concentration and development of ischæmic heart-disease

TL;DR: The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins, and it is proposed that a reduction of plasma-H.H.L.D., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease, by impairing the clearance of cholesterol from the arterial wall.
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Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions

TL;DR: With a single preparative ultracentrifugation, immunologically pure high density lipoproteins can be isolated from large volumes of serum.
Journal ArticleDOI

The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations.

TL;DR: During the first 24 h after injection of 125I-labeled very low density lipoprotein to humans, the decay rate of low densitylipoprotein apoprotein from very lowdensity lipoproteins was faster than that of apolipoprotein glutamic acid, apoipoprotein alanine1 and apolipropoteinAlanine2.
Journal ArticleDOI

Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men.

TL;DR: The inverse relation of alpha cholesterol of prevalence of coronary heart disease was independent of beta cholesterol, obesity, and other factors, and the need for further evaluation of the protective effect of the alpha lipoprotein fraction on the development of coronaryHeart disease is suggested.
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