Journal ArticleDOI
A gradient-based method for segmenting FDG-PET images: methodology and validation
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TLDR
The gradient-based segmentation method applied on denoised and deblurred FDG-PET images proved to be more accurate than the source-to-background ratio method.Abstract:
PURPOSE: A new gradient-based method for segmenting FDG-PET images is described and validated. METHODS: The proposed method relies on the watershed transform and hierarchical cluster analysis. To allow a better estimation of the gradient intensity, iteratively reconstructed images were first denoised and deblurred with an edge-preserving filter and a constrained iterative deconvolution algorithm. Validation was first performed on computer-generated 3D phantoms containing spheres, then on a real cylindrical Lucite phantom containing spheres of different volumes ranging from 2.1 to 92.9 ml. Moreover, laryngeal tumours from seven patients were segmented on PET images acquired before laryngectomy by the gradient-based method and the thresholding method based on the source-to-background ratio developed by Daisne (Radiother Oncol 2003;69:247-50). For the spheres, the calculated volumes and radii were compared with the known values; for laryngeal tumours, the volumes were compared with the macroscopic specimens. Volume mismatches were also analysed. RESULTS: On computer-generated phantoms, the deconvolution algorithm decreased the mis-estimate of volumes and radii. For the Lucite phantom, the gradient-based method led to a slight underestimation of sphere volumes (by 10-20%), corresponding to negligible radius differences (0.5-1.1 mm); for laryngeal tumours, the segmented volumes by the gradient-based method agreed with those delineated on the macroscopic specimens, whereas the threshold-based method overestimated the true volume by 68% (p=0.014). Lastly, macroscopic laryngeal specimens were totally encompassed by neither the threshold-based nor the gradient-based volumes. CONCLUSION: The gradient-based segmentation method applied on denoised and deblurred images proved to be more accurate than the source-to-background ratio method.read more
Citations
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Journal ArticleDOI
FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0
Ronald Boellaard,Roberto Delgado-Bolton,Wim J.G. Oyen,Francesco Giammarile,Klaus Tatsch,W. Eschner,Fred J. Verzijlbergen,Sally F. Barrington,Lucy Pike,Wolfgang A. Weber,Sigrid Stroobants,Dominique Delbeke,Kevin J. Donohoe,Scott Holbrook,Michael M. Graham,Giorgio Testanera,Otto S. Hoekstra,Josée M. Zijlstra,Eric P. Visser,Corneline J. Hoekstra,Jan Pruim,Antoon T.M. Willemsen,Bertjan Arends,Joerg Kotzerke,Andreas Bockisch,Thomas Beyer,Arturo Chiti,Bernd J. Krause +27 more
TL;DR: Both the previous and these new guidelines specifically aim to achieve standardised uptake value harmonisation in multicentre settings.
Journal ArticleDOI
FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0
Ronald Boellaard,Michael O'Doherty,Wolfgang A. Weber,Felix M. Mottaghy,Markus Nowak Lonsdale,Sigrid Stroobants,Wim J.G. Oyen,Joerg Kotzerke,Otto S. Hoekstra,Jan Pruim,Paul Marsden,Klaus Tatsch,Corneline J. Hoekstra,Eric P. Visser,Bertjan Arends,Fred J. Verzijlbergen,Josée M. Zijlstra,Emile F.I. Comans,Adriaan A. Lammertsma,Anne M. J. Paans,Antoon T. M. Willemsen,Thomas Beyer,Andreas Bockisch,Cornelia M. Schaefer-Prokop,Dominique Delbeke,Richard P. Baum,Arturo Chiti,Bernd J. Krause +27 more
TL;DR: This guideline will address general information about [18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) and is provided to help the physician and physicist to assist to carrying out, interpret, and document quantitative FDG PET/CT examinations.
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Standards for PET Image Acquisition and Quantitative Data Analysis
TL;DR: An overview of recommendations and guidelines for quantitative 18F-FDG PET studies in oncology is provided, with special attention given to the rationale underlying certain recommendations and to some of the differences in various guidelines.
Journal ArticleDOI
Characterization of PET/CT images using texture analysis: the past, the present… any future?
Mathieu Hatt,Florent Tixier,Larry Pierce,Paul E. Kinahan,Catherine Cheze Le Rest,Dimitris Visvikis +5 more
TL;DR: Critical insights into the recent development of texture analysis for quantifying the heterogeneity in PET/CT images are provided, issues and challenges are identified, and a list of correct formulae for usual features and recommendations regarding implementation are provided.
Journal ArticleDOI
Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-2007.
Michael MacManus,Michael MacManus,Ursula Nestle,Kenneth E. Rosenzweig,Ignasi Carrió,Cristina Messa,Cristina Messa,Otakar Belohlavek,Massimo Danna,Tomio Inoue,Elizabeth Deniaud-Alexandre,S. Schipani,Naoyuki Watanabe,Maurizio Dondi,Branislav Jeremic +14 more
TL;DR: The best available approach employs integrated PET/CT images, acquired on a dual scanner in the radiotherapy treatment position after administration of tracer according to a standardized protocol, with careful optimization of images within the RT planning system and carefully considered rules for contouring tumor volumes.
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Journal ArticleDOI
Revised response criteria for malignant lymphoma
Bruce D. Cheson,Beate Pfistner,Malik E. Juweid,Randy D. Gascoyne,Lena Specht,Sandra J. Horning,Bertrand Coiffier,Richard I. Fisher,Anton Hagenbeek,Emanuele Zucca,Steven T. Rosen,Sigrid Stroobants,T. Andrew Lister,Richard T. Hoppe,Martin Dreyling,Kensei Tobinai,Julie M. Vose,Joseph M. Connors,Massimo Federico,Volker Diehl +19 more
TL;DR: New guidelines incorporating PET, IHC, and flow cytometry for definitions of response in non-Hodgkin's and Hodgkin's lymphoma are presented and it is hoped that they will be adopted widely by study groups, pharmaceutical and biotechnology companies, and regulatory agencies to facilitate the development of new and more effective therapies to improve the outcome of patients with lymphoma.